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A retrospective longitudinal cohort study of antihypertensive drug use and new-onset diabetes in Taiwanese patients.
Biomed Res Int 2013; 2013:287696BR

Abstract

Antihypertensive drugs have been linked to new-onset diabetes (NOD); however, data on the effect of these drugs on the development of NOD in hypertensive patients has not been well determined in a clinical setting. The aim was to investigate the association between antihypertensive drugs and NOD in Taiwan. We conducted a retrospective study of hypertensive Taiwanese patients receiving antihypertensive drugs treatment between January 2006 and December 2011. Clinical information and laboratory parameters were collected by reviewing the medical records. We estimated the odds ratios (ORs) of NOD associated with antihypertensive drug use; nondiabetic subjects served as the reference group. A total of 120 NOD cases were identified in 1001 hypertensive patients during the study period. The risk of NOD after adjusting sex, age, baseline characteristics, and lipid profiles was higher among users of thiazide diuretics (OR, 1.65; 95% confidence interval (CI), 1.12-2.45) and nondihydropyridine (non-DHP) calcium channel blockers (CCBs) (OR, 1.96; 95% CI, 1.01-3.75) than among nonusers. Other antihypertensive drug classes were not associated with risk of NOD. Our results show that patients with hypertension who take thiazide diuretics and non-DHP CCBs are at higher risk of developing NOD than those who take other classes of antihypertensive drugs in Taiwan.

Authors+Show Affiliations

Department of Pharmacy, China Medical University Hospital, Beikang Campus, Taichung 40402, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23509704

Citation

Huang, Ching-Ya, et al. "A Retrospective Longitudinal Cohort Study of Antihypertensive Drug Use and New-onset Diabetes in Taiwanese Patients." BioMed Research International, vol. 2013, 2013, p. 287696.
Huang CY, Ma T, Tien L, et al. A retrospective longitudinal cohort study of antihypertensive drug use and new-onset diabetes in Taiwanese patients. Biomed Res Int. 2013;2013:287696.
Huang, C. Y., Ma, T., Tien, L., Hsieh, Y. W., Lee, S. Y., Chen, H. Y., & Jong, G. P. (2013). A retrospective longitudinal cohort study of antihypertensive drug use and new-onset diabetes in Taiwanese patients. BioMed Research International, 2013, p. 287696. doi:10.1155/2013/287696.
Huang CY, et al. A Retrospective Longitudinal Cohort Study of Antihypertensive Drug Use and New-onset Diabetes in Taiwanese Patients. Biomed Res Int. 2013;2013:287696. PubMed PMID: 23509704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A retrospective longitudinal cohort study of antihypertensive drug use and new-onset diabetes in Taiwanese patients. AU - Huang,Ching-Ya, AU - Ma,Tsochiang, AU - Tien,Liyun, AU - Hsieh,Yow-Wen, AU - Lee,Shwu-Yi, AU - Chen,Hung-Yi, AU - Jong,Gwo-Ping, Y1 - 2012/12/23/ PY - 2012/08/27/received PY - 2012/10/28/revised PY - 2012/11/06/accepted PY - 2013/3/20/entrez PY - 2013/3/20/pubmed PY - 2013/11/13/medline SP - 287696 EP - 287696 JF - BioMed research international JO - Biomed Res Int VL - 2013 N2 - Antihypertensive drugs have been linked to new-onset diabetes (NOD); however, data on the effect of these drugs on the development of NOD in hypertensive patients has not been well determined in a clinical setting. The aim was to investigate the association between antihypertensive drugs and NOD in Taiwan. We conducted a retrospective study of hypertensive Taiwanese patients receiving antihypertensive drugs treatment between January 2006 and December 2011. Clinical information and laboratory parameters were collected by reviewing the medical records. We estimated the odds ratios (ORs) of NOD associated with antihypertensive drug use; nondiabetic subjects served as the reference group. A total of 120 NOD cases were identified in 1001 hypertensive patients during the study period. The risk of NOD after adjusting sex, age, baseline characteristics, and lipid profiles was higher among users of thiazide diuretics (OR, 1.65; 95% confidence interval (CI), 1.12-2.45) and nondihydropyridine (non-DHP) calcium channel blockers (CCBs) (OR, 1.96; 95% CI, 1.01-3.75) than among nonusers. Other antihypertensive drug classes were not associated with risk of NOD. Our results show that patients with hypertension who take thiazide diuretics and non-DHP CCBs are at higher risk of developing NOD than those who take other classes of antihypertensive drugs in Taiwan. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/23509704/A_retrospective_longitudinal_cohort_study_of_antihypertensive_drug_use_and_new_onset_diabetes_in_Taiwanese_patients_ L2 - https://dx.doi.org/10.1155/2013/287696 DB - PRIME DP - Unbound Medicine ER -