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Differential expression and seasonal variation on aquaporins 1 and 9 in the male genital system of big fruit-eating bat Artibeus lituratus.
Gen Comp Endocrinol. 2013 Jun 01; 186:116-25.GC

Abstract

Efferent ductules and epididymis are involved in water and solute transport, which is indispensable for storage and maintenance of the sperm viability. The reabsorption process involves proteins such as aquaporins (AQP), which has been described in the male genital system of limited species, including primate, rodents, cats and dogs. To contribute with information about AQPs in the male system, here we investigated the distribution of AQP1 and AQP9 in the tropical bat Artibeus lituratus, along the annual reproductive cycle. A. lituratus is a seasonal breeder with natural variation in components of the androgen and estrogen responsive system, thus being a good model for exploring the AQPs modulation. AQP1 was found restricted to differentiating spermatids, efferent ductules epithelium and venular endothelia along the male tract. AQP9 was detected throughout the epididymis being more abundant in the cauda and ductus deferens, but was not found in testis, rete testis and efferent ductules. Contrasting with AQP1 which appear to be constitutively expressed, there was seasonal variation in AQP9 expression, which was reduced in regressed epididymis. The AQP9 does not appear to be modulated by estradiol or androgens, but possibly by other factor related to luminal sperm. The establishment of specific function for aquaporins in the male tract remains undetermined; however, the cellular distribution presently found are compatible with the main function of AQP1, as a selective water channel, and AQP9, which is a conduct for water and a plethora of neutral solutes present in the epididymis milieu such as glycerol and urea.

Authors+Show Affiliations

Department of Morphology, Universidade Federal de Minas Gerais, Cx. Postal 486, CEP 31270-901 Belo Horizonte, Minas Gerais, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23510858

Citation

Oliveira, Regiana L., et al. "Differential Expression and Seasonal Variation On Aquaporins 1 and 9 in the Male Genital System of Big Fruit-eating Bat Artibeus Lituratus." General and Comparative Endocrinology, vol. 186, 2013, pp. 116-25.
Oliveira RL, Campolina-Silva GH, Nogueira JC, et al. Differential expression and seasonal variation on aquaporins 1 and 9 in the male genital system of big fruit-eating bat Artibeus lituratus. Gen Comp Endocrinol. 2013;186:116-25.
Oliveira, R. L., Campolina-Silva, G. H., Nogueira, J. C., Mahecha, G. A., & Oliveira, C. A. (2013). Differential expression and seasonal variation on aquaporins 1 and 9 in the male genital system of big fruit-eating bat Artibeus lituratus. General and Comparative Endocrinology, 186, 116-25. https://doi.org/10.1016/j.ygcen.2013.02.041
Oliveira RL, et al. Differential Expression and Seasonal Variation On Aquaporins 1 and 9 in the Male Genital System of Big Fruit-eating Bat Artibeus Lituratus. Gen Comp Endocrinol. 2013 Jun 1;186:116-25. PubMed PMID: 23510858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential expression and seasonal variation on aquaporins 1 and 9 in the male genital system of big fruit-eating bat Artibeus lituratus. AU - Oliveira,Regiana L, AU - Campolina-Silva,Gabriel H, AU - Nogueira,José C, AU - Mahecha,Germán A B, AU - Oliveira,Cleida A, Y1 - 2013/03/16/ PY - 2012/12/05/received PY - 2013/02/22/revised PY - 2013/02/24/accepted PY - 2013/3/21/entrez PY - 2013/3/21/pubmed PY - 2013/12/16/medline SP - 116 EP - 25 JF - General and comparative endocrinology JO - Gen Comp Endocrinol VL - 186 N2 - Efferent ductules and epididymis are involved in water and solute transport, which is indispensable for storage and maintenance of the sperm viability. The reabsorption process involves proteins such as aquaporins (AQP), which has been described in the male genital system of limited species, including primate, rodents, cats and dogs. To contribute with information about AQPs in the male system, here we investigated the distribution of AQP1 and AQP9 in the tropical bat Artibeus lituratus, along the annual reproductive cycle. A. lituratus is a seasonal breeder with natural variation in components of the androgen and estrogen responsive system, thus being a good model for exploring the AQPs modulation. AQP1 was found restricted to differentiating spermatids, efferent ductules epithelium and venular endothelia along the male tract. AQP9 was detected throughout the epididymis being more abundant in the cauda and ductus deferens, but was not found in testis, rete testis and efferent ductules. Contrasting with AQP1 which appear to be constitutively expressed, there was seasonal variation in AQP9 expression, which was reduced in regressed epididymis. The AQP9 does not appear to be modulated by estradiol or androgens, but possibly by other factor related to luminal sperm. The establishment of specific function for aquaporins in the male tract remains undetermined; however, the cellular distribution presently found are compatible with the main function of AQP1, as a selective water channel, and AQP9, which is a conduct for water and a plethora of neutral solutes present in the epididymis milieu such as glycerol and urea. SN - 1095-6840 UR - https://www.unboundmedicine.com/medline/citation/23510858/Differential_expression_and_seasonal_variation_on_aquaporins_1_and_9_in_the_male_genital_system_of_big_fruit_eating_bat_Artibeus_lituratus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-6480(13)00118-4 DB - PRIME DP - Unbound Medicine ER -