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Click synthesis of neutral, cationic, and zwitterionic poly(propargyl glycolide)-co-poly(ɛ-caprolactone)-based aliphatic polyesters as antifouling biomaterials.
Colloids Surf B Biointerfaces. 2013 Aug 01; 108:34-43.CS

Abstract

With the development of polymer-based biomaterials, aliphatic polyesters have attracted considerable interest because of their non-toxicity, non-allergenic property, and good biocompatibility. However, the hydrophobic nature and the lack of side chain functionalities of aliphatic polyesters limit their biomedical applications. In this study, we prepared four new polyesters: poly(sulfobetaine methacrylate)-, poly(2-methacryloyloxyethyl phosphotidylcholine)-, poly(ethylene glycol)-, and quaternized poly[(2-dimethylamino)ethyl methacrylate]-grafted poly(propargyl glycolide)-co-poly(ɛ-caprolactone). Their synthesis was conducted through ring-opening polymerization of acetylene-functionalized lactones and subsequent graft of bioactive units using click chemistry. The chemical structures of the polyesters were characterized through nuclear magnetic resonance and Fourier-transform infrared spectroscopy, and their physical properties (including molecular weight, glass transition temperature, and melting point) were determined using gel permeation chromatography and differential scanning calorimetry. For studies on their hydrophilicity, stability, and anti-bioadhesive property, a series of polymeric surfaces of these polyesters was prepared by coating them onto glass substrates. The hydrophilicity and stability of these polyester surfaces were examined by contact angle measurements and attenuated total reflection Fourier-transform infrared spectroscopy. Their anti-bioadhesive property was investigated through protein adsorption, as well as cellular and bacterial adhesion assays. The prepared polyesters showed good hydrophilicity and long-lasting stability, as well as significant anti-fouling property. The newly prepared polyesters could be developed as promising anti-fouling materials with extensive biomedical applications.

Authors+Show Affiliations

College of Science, Northwest A&F University, Yangling, Shaanxi 712100, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23511626

Citation

Tu, Qin, et al. "Click Synthesis of Neutral, Cationic, and Zwitterionic Poly(propargyl Glycolide)-co-poly(ɛ-caprolactone)-based Aliphatic Polyesters as Antifouling Biomaterials." Colloids and Surfaces. B, Biointerfaces, vol. 108, 2013, pp. 34-43.
Tu Q, Wang JC, Liu R, et al. Click synthesis of neutral, cationic, and zwitterionic poly(propargyl glycolide)-co-poly(ɛ-caprolactone)-based aliphatic polyesters as antifouling biomaterials. Colloids Surf B Biointerfaces. 2013;108:34-43.
Tu, Q., Wang, J. C., Liu, R., Chen, Y., Zhang, Y., Wang, D. E., Yuan, M. S., Xu, J., & Wang, J. (2013). Click synthesis of neutral, cationic, and zwitterionic poly(propargyl glycolide)-co-poly(ɛ-caprolactone)-based aliphatic polyesters as antifouling biomaterials. Colloids and Surfaces. B, Biointerfaces, 108, 34-43. https://doi.org/10.1016/j.colsurfb.2013.02.006
Tu Q, et al. Click Synthesis of Neutral, Cationic, and Zwitterionic Poly(propargyl Glycolide)-co-poly(ɛ-caprolactone)-based Aliphatic Polyesters as Antifouling Biomaterials. Colloids Surf B Biointerfaces. 2013 Aug 1;108:34-43. PubMed PMID: 23511626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Click synthesis of neutral, cationic, and zwitterionic poly(propargyl glycolide)-co-poly(ɛ-caprolactone)-based aliphatic polyesters as antifouling biomaterials. AU - Tu,Qin, AU - Wang,Jian-Chun, AU - Liu,Rui, AU - Chen,Yun, AU - Zhang,Yanrong, AU - Wang,Dong-En, AU - Yuan,Mao-Sen, AU - Xu,Juan, AU - Wang,Jinyi, Y1 - 2013/02/21/ PY - 2012/12/23/received PY - 2013/02/13/revised PY - 2013/02/13/accepted PY - 2013/3/21/entrez PY - 2013/3/21/pubmed PY - 2013/11/13/medline SP - 34 EP - 43 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 108 N2 - With the development of polymer-based biomaterials, aliphatic polyesters have attracted considerable interest because of their non-toxicity, non-allergenic property, and good biocompatibility. However, the hydrophobic nature and the lack of side chain functionalities of aliphatic polyesters limit their biomedical applications. In this study, we prepared four new polyesters: poly(sulfobetaine methacrylate)-, poly(2-methacryloyloxyethyl phosphotidylcholine)-, poly(ethylene glycol)-, and quaternized poly[(2-dimethylamino)ethyl methacrylate]-grafted poly(propargyl glycolide)-co-poly(ɛ-caprolactone). Their synthesis was conducted through ring-opening polymerization of acetylene-functionalized lactones and subsequent graft of bioactive units using click chemistry. The chemical structures of the polyesters were characterized through nuclear magnetic resonance and Fourier-transform infrared spectroscopy, and their physical properties (including molecular weight, glass transition temperature, and melting point) were determined using gel permeation chromatography and differential scanning calorimetry. For studies on their hydrophilicity, stability, and anti-bioadhesive property, a series of polymeric surfaces of these polyesters was prepared by coating them onto glass substrates. The hydrophilicity and stability of these polyester surfaces were examined by contact angle measurements and attenuated total reflection Fourier-transform infrared spectroscopy. Their anti-bioadhesive property was investigated through protein adsorption, as well as cellular and bacterial adhesion assays. The prepared polyesters showed good hydrophilicity and long-lasting stability, as well as significant anti-fouling property. The newly prepared polyesters could be developed as promising anti-fouling materials with extensive biomedical applications. SN - 1873-4367 UR - https://www.unboundmedicine.com/medline/citation/23511626/Click_synthesis_of_neutral_cationic_and_zwitterionic_poly_propargyl_glycolide__co_poly_ɛ_caprolactone__based_aliphatic_polyesters_as_antifouling_biomaterials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0927-7765(13)00126-4 DB - PRIME DP - Unbound Medicine ER -