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High-intensity vs. sham inspiratory muscle training in patients with chronic heart failure: a prospective randomized trial.
Eur J Heart Fail 2013; 15(8):892-901EJ

Abstract

AIMS

The purpose of this study was to evaluate the effectiveness, feasibility, and safety of a 4-week high-intensity inspiratory muscle training (hi-IMT) in patients with chronic heart failure (CHF).

METHODS AND RESULTS

A double-blind randomized clinical trial was carried out in 22 patients with CHF. Participants were assigned to the hi-IMT or sham-IMT group. The trainer device was a prototype of the Orygen-Dual Valve. The training workloads were adjusted weekly at the inspiratory pressure which allowed the performance of 10 consecutive maximal repetitions (10RM). Main outcomes were strength and endurance of the respiratory muscles assessed by maximal respiratory pressures (PImax and PEmax) and a 10RM manoeuvre, respectively. Twenty-one patients presented impairment in respiratory muscle strength and endurance. Patients in the hi-IMT group showed a significant improvement in both strength and endurance: inspiratory muscle strength in the intervention group increased 57.2% compared with 25.9% in the control group (P = 0.001). The percentage change in endurance was 72.7% for the hi-IMT group compared with 18.2% in the sham-IMT group (P < 0.001). No adverse effects occurred during the intervention.

CONCLUSION

A 4-week hi-IMT with the use of the Orygen-Dual Valve is shown to be an effective, feasible, and safe tool to improve weakness and fatigue of the inspiratory muscles. The key point of this study is to discuss immediate practical implications in terms of respiratory muscle dysfunction postulated as a potential prognostic factor and as an additional therapeutic target.

TRIALS REGISTRATION

NCT01606553.

Authors+Show Affiliations

Physical Medicine and Rehabilitation Department, Hospital del Mar, Barcelona, Catalonia, Spain. emarco@parcdesalutmar.catNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

23512093

Citation

Marco, Ester, et al. "High-intensity Vs. Sham Inspiratory Muscle Training in Patients With Chronic Heart Failure: a Prospective Randomized Trial." European Journal of Heart Failure, vol. 15, no. 8, 2013, pp. 892-901.
Marco E, Ramírez-Sarmiento AL, Coloma A, et al. High-intensity vs. sham inspiratory muscle training in patients with chronic heart failure: a prospective randomized trial. Eur J Heart Fail. 2013;15(8):892-901.
Marco, E., Ramírez-Sarmiento, A. L., Coloma, A., Sartor, M., Comin-Colet, J., Vila, J., ... Orozco-Levi, M. (2013). High-intensity vs. sham inspiratory muscle training in patients with chronic heart failure: a prospective randomized trial. European Journal of Heart Failure, 15(8), pp. 892-901. doi:10.1093/eurjhf/hft035.
Marco E, et al. High-intensity Vs. Sham Inspiratory Muscle Training in Patients With Chronic Heart Failure: a Prospective Randomized Trial. Eur J Heart Fail. 2013;15(8):892-901. PubMed PMID: 23512093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-intensity vs. sham inspiratory muscle training in patients with chronic heart failure: a prospective randomized trial. AU - Marco,Ester, AU - Ramírez-Sarmiento,Alba L, AU - Coloma,Ana, AU - Sartor,Monique, AU - Comin-Colet,Josep, AU - Vila,Joan, AU - Enjuanes,Cristina, AU - Bruguera,Jordi, AU - Escalada,Ferran, AU - Gea,Joaquim, AU - Orozco-Levi,Mauricio, Y1 - 2013/03/19/ PY - 2013/3/21/entrez PY - 2013/3/21/pubmed PY - 2014/3/13/medline KW - Cardiopulmonary rehabilitation KW - Heart failure KW - Inspiratory muscle training KW - Muscle endurance KW - Muscle strength SP - 892 EP - 901 JF - European journal of heart failure JO - Eur. J. Heart Fail. VL - 15 IS - 8 N2 - AIMS: The purpose of this study was to evaluate the effectiveness, feasibility, and safety of a 4-week high-intensity inspiratory muscle training (hi-IMT) in patients with chronic heart failure (CHF). METHODS AND RESULTS: A double-blind randomized clinical trial was carried out in 22 patients with CHF. Participants were assigned to the hi-IMT or sham-IMT group. The trainer device was a prototype of the Orygen-Dual Valve. The training workloads were adjusted weekly at the inspiratory pressure which allowed the performance of 10 consecutive maximal repetitions (10RM). Main outcomes were strength and endurance of the respiratory muscles assessed by maximal respiratory pressures (PImax and PEmax) and a 10RM manoeuvre, respectively. Twenty-one patients presented impairment in respiratory muscle strength and endurance. Patients in the hi-IMT group showed a significant improvement in both strength and endurance: inspiratory muscle strength in the intervention group increased 57.2% compared with 25.9% in the control group (P = 0.001). The percentage change in endurance was 72.7% for the hi-IMT group compared with 18.2% in the sham-IMT group (P < 0.001). No adverse effects occurred during the intervention. CONCLUSION: A 4-week hi-IMT with the use of the Orygen-Dual Valve is shown to be an effective, feasible, and safe tool to improve weakness and fatigue of the inspiratory muscles. The key point of this study is to discuss immediate practical implications in terms of respiratory muscle dysfunction postulated as a potential prognostic factor and as an additional therapeutic target. TRIALS REGISTRATION: NCT01606553. SN - 1879-0844 UR - https://www.unboundmedicine.com/medline/citation/23512093/High_intensity_vs__sham_inspiratory_muscle_training_in_patients_with_chronic_heart_failure:_a_prospective_randomized_trial_ L2 - https://doi.org/10.1093/eurjhf/hft035 DB - PRIME DP - Unbound Medicine ER -