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Hop extracts and hop substances in treatment of menopausal complaints.
Planta Med. 2013 May; 79(7):576-9.PM

Abstract

Hop extract is a long used medicinal product and, regarding hormonal activities, in 1999 a number of prenylflavanones have been identified as its major constituents with 8-prenylnaringenin (8-PN) being the main active estrogenic compound. There have been several in vivo studies performed that demonstrate the potential of hop extract and the single compound 8-PN to alleviate climacteric symptoms like osteoporosis, vasomotoric complaints, and sexual motivation. On the other hand, only a few clinical studies have been performed so far, and these mainly focused on menopausal discomforts, especially hot flushes, yielding rather inconclusive results. Despite preferentially activating estrogen receptor α, 8-PN is only slightly uterotrophic, but it also elucidates estrogenic effects on the mammary gland. In conclusion, although hop extract and especially 8-PN are promising candidates as a relief for climacteric symptoms, data on the safety and efficacy is still scarce.

Links

Publisher Full Text
thieme-connect.com
thieme-connect.com

Authors+Show Affiliations

Keiler AM
Institute of Zoology, Molecular Cell Physiology and Endocrinology, Technische Universität Dresden, Dresden, Germany. Annekathrin.Keiler@tu-dresden.de
Zierau O
No affiliation info available
Kretzschmar G
No affiliation info available

MeSH

Estrogen Receptor alphaFemaleFlavanonesHot FlashesHumansHumulusMammary Glands, HumanMenopauseOsteoporosis, PostmenopausalPhytoestrogensPhytotherapyPlant ExtractsSexual Dysfunctions, PsychologicalUterus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23512496

Citation

Keiler, Annekathrin M., et al. "Hop Extracts and Hop Substances in Treatment of Menopausal Complaints." Planta Medica, vol. 79, no. 7, 2013, pp. 576-9.
Keiler AM, Zierau O, Kretzschmar G. Hop extracts and hop substances in treatment of menopausal complaints. Planta Med. 2013;79(7):576-9.
Keiler, A. M., Zierau, O., & Kretzschmar, G. (2013). Hop extracts and hop substances in treatment of menopausal complaints. Planta Medica, 79(7), 576-9. https://doi.org/10.1055/s-0032-1328330
Keiler AM, Zierau O, Kretzschmar G. Hop Extracts and Hop Substances in Treatment of Menopausal Complaints. Planta Med. 2013;79(7):576-9. PubMed PMID: 23512496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hop extracts and hop substances in treatment of menopausal complaints. AU - Keiler,Annekathrin M, AU - Zierau,Oliver, AU - Kretzschmar,Georg, Y1 - 2013/03/19/ PY - 2013/3/21/entrez PY - 2013/3/21/pubmed PY - 2013/11/2/medline SP - 576 EP - 9 JF - Planta medica JO - Planta Med VL - 79 IS - 7 N2 - Hop extract is a long used medicinal product and, regarding hormonal activities, in 1999 a number of prenylflavanones have been identified as its major constituents with 8-prenylnaringenin (8-PN) being the main active estrogenic compound. There have been several in vivo studies performed that demonstrate the potential of hop extract and the single compound 8-PN to alleviate climacteric symptoms like osteoporosis, vasomotoric complaints, and sexual motivation. On the other hand, only a few clinical studies have been performed so far, and these mainly focused on menopausal discomforts, especially hot flushes, yielding rather inconclusive results. Despite preferentially activating estrogen receptor α, 8-PN is only slightly uterotrophic, but it also elucidates estrogenic effects on the mammary gland. In conclusion, although hop extract and especially 8-PN are promising candidates as a relief for climacteric symptoms, data on the safety and efficacy is still scarce. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/23512496/Hop_extracts_and_hop_substances_in_treatment_of_menopausal_complaints_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0032-1328330 DB - PRIME DP - Unbound Medicine ER -