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The protective effects of ω-3 fatty acids on doxorubicin-induced hepatotoxicity and nephrotoxicity in rats.

Abstract

This study aims to evaluate the protective effects of ω-3 fatty acids (FAs) on doxorubicin (DOX)-induced hepatotoxicity and nephrotoxicity in rats. A total of 24 adult male Sprague Dawley rats were divided into three groups. Control group was given only saline by intragastric gavage. DOX group received DOX at the dose of 30 mg/kg intraperitoneally on day 28. DOX-ω-3 FA group was given as ω-3 FAs at the dose of 400 mg/kg daily by intragastric gavage for 30 days and received DOX at the dose of 30 mg/kg intraperitoneally on day 28. At the end of the 30-day experimental period, the serum, liver and kidney tissue specimens were taken from the animals by giving a general anesthesia. Glutathione (GSH) and malondialdehyde (MDA) levels in serum and GSH and MDA levels and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in liver and kidney tissues were measured spectrophotometrically. In our study, a significant increase in MDA levels was observed in rats when given a dose of DOX and a significant decrease in the levels of GSH, SOD and GSH-Px activities in serum, liver and kidney tissues was determined when compared with control group. In addition, a significant decrease in MDA levels was observed in rats when a dose of ω-3 FAs was given with DOX and a significant increase was determined in the levels of GSH, SOD and GSH-Px activities in serum, liver and kidney tissues, when compared with DOX group. We concluded that ω-3 FA had favorable effects in rat liver and kidney tissues by preventing oxidative damage.

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  • Authors+Show Affiliations

    ,

    Department of Medical Biochemistry, Faculty of Medicine, Namık Kemal University, Tekirdağ, Turkey ftulubas@yahoo.com.

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    Department of Medical Biochemistry, Faculty of Medicine, Namık Kemal University, Tekirdağ, Turkey.

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    Department of Internal Medicine, Faculty of Medicine, Namık Kemal University, Tekirdağ, Turkey.

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    Department of Biostatistics and Medical Informatics, Faculty of Medicine, Namık Kemal University, Tekirdağ, Turkey.

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    Department of Anatomy, Faculty of Medicine, Namık Kemal University, Tekirdağ, Turkey.

    School of Health Services, Namık Kemal University, Tekirdağ, Turkey.

    Source

    Toxicology and industrial health 31:7 2015 Jul pg 638-44

    MeSH

    Animals
    Antibiotics, Antineoplastic
    Doxorubicin
    Euthanasia, Animal
    Fatty Acids, Omega-3
    Glutathione
    Glutathione Peroxidase
    Kidney
    Liver
    Male
    Malondialdehyde
    Oxidative Stress
    Random Allocation
    Rats
    Rats, Sprague-Dawley
    Superoxide Dismutase

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    23512535