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Probiotics L. plantarum and L. curvatus in combination alter hepatic lipid metabolism and suppress diet-induced obesity.
Obesity (Silver Spring) 2013; 21(12):2571-8O

Abstract

OBJECTIVE

To determine the effects of naturally derived probiotic strains individually or combination on a short-term diet-induced obesity model.

DESIGN AND METHODS

C57BL/6J mice (n = 50) were randomly divided into five groups, then fed a high-fat high-cholesterol diet (HFCD), HFCD and Lactobacillus plantarum KY1032 (PL, 10(10) cfu/day), HFCD and Lactobacillus curvatus HY7601 (CU, 10(10) cfu/day), HFCD and in combination with PL+CU (10(10) cfu/day), or a normal diet (ND) for 9 weeks.

RESULTS

PL and CU showed distinct and shared metabolic activity against a panel of 50 carbohydrates. Fat accumulation in adipose tissue and liver was significantly reduced by probiotic strains CU or PL+CU. Probiotic strains CU or PL+CU reduced cholesterol in plasma and liver, while PL+CL had a synergistic effect on hepatic triglycerides. Probiotic strains PL+CU combination was more effective for inhibiting gene expressions of various fatty acid synthesis enzymes in the liver, concomitant with decreases in fatty acid oxidation-related enzyme activities and their gene expressions.

CONCLUSIONS

Multi-strain probiotics may prove more beneficial than single-strain probiotics to combat fat accumulation and metabolic alterations in diet-induced obesity.

Authors+Show Affiliations

Department of Food Science and Nutrition, Center for Food & Nutritional Genomics, Kyungpook National University, 1370 Sankyuk-dong, Buk-gu, Daegu 702-701, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23512789

Citation

Yoo, Sae-Rom, et al. "Probiotics L. Plantarum and L. Curvatus in Combination Alter Hepatic Lipid Metabolism and Suppress Diet-induced Obesity." Obesity (Silver Spring, Md.), vol. 21, no. 12, 2013, pp. 2571-8.
Yoo SR, Kim YJ, Park DY, et al. Probiotics L. plantarum and L. curvatus in combination alter hepatic lipid metabolism and suppress diet-induced obesity. Obesity (Silver Spring). 2013;21(12):2571-8.
Yoo, S. R., Kim, Y. J., Park, D. Y., Jung, U. J., Jeon, S. M., Ahn, Y. T., ... Choi, M. S. (2013). Probiotics L. plantarum and L. curvatus in combination alter hepatic lipid metabolism and suppress diet-induced obesity. Obesity (Silver Spring, Md.), 21(12), pp. 2571-8. doi:10.1002/oby.20428.
Yoo SR, et al. Probiotics L. Plantarum and L. Curvatus in Combination Alter Hepatic Lipid Metabolism and Suppress Diet-induced Obesity. Obesity (Silver Spring). 2013;21(12):2571-8. PubMed PMID: 23512789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Probiotics L. plantarum and L. curvatus in combination alter hepatic lipid metabolism and suppress diet-induced obesity. AU - Yoo,Sae-Rom, AU - Kim,Young-Jae, AU - Park,Do-Young, AU - Jung,Un-Ju, AU - Jeon,Seon-Min, AU - Ahn,Young-Tae, AU - Huh,Chul-Sung, AU - McGregor,Robin, AU - Choi,Myung Sook, Y1 - 2013/06/11/ PY - 2012/03/12/received PY - 2013/02/06/accepted PY - 2013/3/21/entrez PY - 2013/3/21/pubmed PY - 2014/8/12/medline SP - 2571 EP - 8 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 21 IS - 12 N2 - OBJECTIVE: To determine the effects of naturally derived probiotic strains individually or combination on a short-term diet-induced obesity model. DESIGN AND METHODS: C57BL/6J mice (n = 50) were randomly divided into five groups, then fed a high-fat high-cholesterol diet (HFCD), HFCD and Lactobacillus plantarum KY1032 (PL, 10(10) cfu/day), HFCD and Lactobacillus curvatus HY7601 (CU, 10(10) cfu/day), HFCD and in combination with PL+CU (10(10) cfu/day), or a normal diet (ND) for 9 weeks. RESULTS: PL and CU showed distinct and shared metabolic activity against a panel of 50 carbohydrates. Fat accumulation in adipose tissue and liver was significantly reduced by probiotic strains CU or PL+CU. Probiotic strains CU or PL+CU reduced cholesterol in plasma and liver, while PL+CL had a synergistic effect on hepatic triglycerides. Probiotic strains PL+CU combination was more effective for inhibiting gene expressions of various fatty acid synthesis enzymes in the liver, concomitant with decreases in fatty acid oxidation-related enzyme activities and their gene expressions. CONCLUSIONS: Multi-strain probiotics may prove more beneficial than single-strain probiotics to combat fat accumulation and metabolic alterations in diet-induced obesity. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/23512789/Probiotics_L__plantarum_and_L__curvatus_in_combination_alter_hepatic_lipid_metabolism_and_suppress_diet_induced_obesity_ L2 - https://doi.org/10.1002/oby.20428 DB - PRIME DP - Unbound Medicine ER -