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[Vitamin B12 deficiency: neurological disease with minimal or no anemia].
Harefuah. 1990 Apr 01; 118(7):385-6.H

Abstract

3 patients with vitamin B12 deficiency are described (men aged 64 and 67 and a women of 75). All presented with neurological disease; 2 had had severe weight loss. In 1 neither anemia nor macrocytosis was found, while in 2 there was only mild macrocytic anemia, so that the diagnosis was established quite late during the disease. These patients demonstrate that a high index of suspicion is required to diagnose vitamin B12 deficiency when there are only mild or no hematological abnormalities. This is especially important because of the direct relation between time elapsed before therapy and the irreversibility of neurological damage. Of note is the severe weight loss simulating malignant disease that can be the presenting symptom or appear during the course of the disease.

Authors+Show Affiliations

Dept. of Medicine E, Chaim Sheba Medical Center, Tel Hashomer.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

heb

PubMed ID

2351346

Citation

Mouallem, M, et al. "[Vitamin B12 Deficiency: Neurological Disease With Minimal or No Anemia]." Harefuah, vol. 118, no. 7, 1990, pp. 385-6.
Mouallem M, Pauzner R, Maayan H, et al. [Vitamin B12 deficiency: neurological disease with minimal or no anemia]. Harefuah. 1990;118(7):385-6.
Mouallem, M., Pauzner, R., Maayan, H., & Farfel, Z. (1990). [Vitamin B12 deficiency: neurological disease with minimal or no anemia]. Harefuah, 118(7), 385-6.
Mouallem M, et al. [Vitamin B12 Deficiency: Neurological Disease With Minimal or No Anemia]. Harefuah. 1990 Apr 1;118(7):385-6. PubMed PMID: 2351346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Vitamin B12 deficiency: neurological disease with minimal or no anemia]. AU - Mouallem,M, AU - Pauzner,R, AU - Maayan,H, AU - Farfel,Z, PY - 1990/4/1/pubmed PY - 1990/4/1/medline PY - 1990/4/1/entrez SP - 385 EP - 6 JF - Harefuah JO - Harefuah VL - 118 IS - 7 N2 - 3 patients with vitamin B12 deficiency are described (men aged 64 and 67 and a women of 75). All presented with neurological disease; 2 had had severe weight loss. In 1 neither anemia nor macrocytosis was found, while in 2 there was only mild macrocytic anemia, so that the diagnosis was established quite late during the disease. These patients demonstrate that a high index of suspicion is required to diagnose vitamin B12 deficiency when there are only mild or no hematological abnormalities. This is especially important because of the direct relation between time elapsed before therapy and the irreversibility of neurological damage. Of note is the severe weight loss simulating malignant disease that can be the presenting symptom or appear during the course of the disease. SN - 0017-7768 UR - https://www.unboundmedicine.com/medline/citation/2351346/[Vitamin_B12_deficiency:_neurological_disease_with_minimal_or_no_anemia]_ DB - PRIME DP - Unbound Medicine ER -