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Composition, in-vitro anticancer, and antimicrobial activities of the leaf essential oil of Machilus mushaensis from Taiwan.
Nat Prod Commun. 2013 Feb; 8(2):273-5.NP

Abstract

This study investigated the chemical composition, in-vitro anticancer, and antimicrobial activities of the essential oil isolated from the leaf of Machilus mushaensis from Taiwan. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Forty compounds were identified, representing 100% of the oil. The main components identified were n-decanal (61.0%), and alpha-cadinol (20.8%). The oil exhibited cytotoxic activity against human oral, liver, lung, colon, melanoma, and leukemic cancer cells. The antimicrobial activity of the oil was tested by the disc diffusion and micro-broth dilution methods against ten microbial species. The oil exhibited moderate growth suppression against Gram-positive bacteria and yeast with inhibition zones of 25-29 mm to MIC values of 375-500 microg/mL, respectively. alpha-Cadinol was found to show promising anticancer and antimicrobial activities.

Authors+Show Affiliations

Su YC
Department of Forestry, National Chung Hsing University, 250 Kuo Kuang Rd., Taichung, Taiwan 402.
Ho CL
No affiliation info available

MeSH

Anti-Infective AgentsAntineoplastic Agents, PhytogenicLauraceaeMicrobial Sensitivity TestsOils, VolatilePlant LeavesTaiwan

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23513747

Citation

Su, Yu-Chang, and Chen-Lung Ho. "Composition, In-vitro Anticancer, and Antimicrobial Activities of the Leaf Essential Oil of Machilus Mushaensis From Taiwan." Natural Product Communications, vol. 8, no. 2, 2013, pp. 273-5.
Su YC, Ho CL. Composition, in-vitro anticancer, and antimicrobial activities of the leaf essential oil of Machilus mushaensis from Taiwan. Nat Prod Commun. 2013;8(2):273-5.
Su, Y. C., & Ho, C. L. (2013). Composition, in-vitro anticancer, and antimicrobial activities of the leaf essential oil of Machilus mushaensis from Taiwan. Natural Product Communications, 8(2), 273-5.
Su YC, Ho CL. Composition, In-vitro Anticancer, and Antimicrobial Activities of the Leaf Essential Oil of Machilus Mushaensis From Taiwan. Nat Prod Commun. 2013;8(2):273-5. PubMed PMID: 23513747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Composition, in-vitro anticancer, and antimicrobial activities of the leaf essential oil of Machilus mushaensis from Taiwan. AU - Su,Yu-Chang, AU - Ho,Chen-Lung, PY - 2013/3/22/entrez PY - 2013/3/22/pubmed PY - 2013/4/30/medline SP - 273 EP - 5 JF - Natural product communications JO - Nat Prod Commun VL - 8 IS - 2 N2 - This study investigated the chemical composition, in-vitro anticancer, and antimicrobial activities of the essential oil isolated from the leaf of Machilus mushaensis from Taiwan. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Forty compounds were identified, representing 100% of the oil. The main components identified were n-decanal (61.0%), and alpha-cadinol (20.8%). The oil exhibited cytotoxic activity against human oral, liver, lung, colon, melanoma, and leukemic cancer cells. The antimicrobial activity of the oil was tested by the disc diffusion and micro-broth dilution methods against ten microbial species. The oil exhibited moderate growth suppression against Gram-positive bacteria and yeast with inhibition zones of 25-29 mm to MIC values of 375-500 microg/mL, respectively. alpha-Cadinol was found to show promising anticancer and antimicrobial activities. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/23513747/Composition_in_vitro_anticancer_and_antimicrobial_activities_of_the_leaf_essential_oil_of_Machilus_mushaensis_from_Taiwan_ DB - PRIME DP - Unbound Medicine ER -