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Rosmarinus officinalis extract suppresses Propionibacterium acnes-induced inflammatory responses.
J Med Food. 2013 Apr; 16(4):324-33.JM

Abstract

Propionibacterium acnes is a key pathogen involved in the progression of acne inflammation. The development of a new agent possessing antimicrobial and anti-inflammatory activity against P. acnes is therefore of interest. In this study, we investigated the inhibitory effect of rosemary (Rosmarinus officinalis) extract on P. acnes-induced inflammation in vitro and in vivo. The results showed that ethanolic rosemary extract (ERE) significantly suppressed the secretion and mRNA expression of proinflammatory cytokines, including interleukin (IL)-8, IL-1β, and tumor necrosis factor-α in P. acnes-stimulated monocytic THP-1 cells. In an in vivo mouse model, concomitant intradermal injection of ERE attenuated the P. acnes-induced ear swelling and granulomatous inflammation. Since ERE suppressed the P. acnes-induced nuclear factor kappa-B (NF-κB) activation and mRNA expression of Toll-like receptor (TLR) 2, the suppressive effect of ERE might be due, at least partially, to diminished NF-κB activation and TLR2-mediated signaling pathways. Furthermore, three major constituents of ERE, carnosol, carnosic acid, and rosmarinic acid, exerted different immumodulatory activities in vitro. In brief, rosmarinic acid significantly suppressed IL-8 production, while the other two compounds inhibited IL-1β production. Further study is needed to explore the role of bioactive compounds of rosemary in mitigation of P. acnes-induced inflammation.

Authors+Show Affiliations

Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23514231

Citation

Tsai, Tsung-Hsien, et al. "Rosmarinus Officinalis Extract Suppresses Propionibacterium Acnes-induced Inflammatory Responses." Journal of Medicinal Food, vol. 16, no. 4, 2013, pp. 324-33.
Tsai TH, Chuang LT, Lien TJ, et al. Rosmarinus officinalis extract suppresses Propionibacterium acnes-induced inflammatory responses. J Med Food. 2013;16(4):324-33.
Tsai, T. H., Chuang, L. T., Lien, T. J., Liing, Y. R., Chen, W. Y., & Tsai, P. J. (2013). Rosmarinus officinalis extract suppresses Propionibacterium acnes-induced inflammatory responses. Journal of Medicinal Food, 16(4), 324-33. https://doi.org/10.1089/jmf.2012.2577
Tsai TH, et al. Rosmarinus Officinalis Extract Suppresses Propionibacterium Acnes-induced Inflammatory Responses. J Med Food. 2013;16(4):324-33. PubMed PMID: 23514231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rosmarinus officinalis extract suppresses Propionibacterium acnes-induced inflammatory responses. AU - Tsai,Tsung-Hsien, AU - Chuang,Lu-Te, AU - Lien,Tsung-Jung, AU - Liing,Yau-Rong, AU - Chen,Wei-Yu, AU - Tsai,Po-Jung, Y1 - 2013/03/20/ PY - 2013/3/22/entrez PY - 2013/3/22/pubmed PY - 2013/9/18/medline SP - 324 EP - 33 JF - Journal of medicinal food JO - J Med Food VL - 16 IS - 4 N2 - Propionibacterium acnes is a key pathogen involved in the progression of acne inflammation. The development of a new agent possessing antimicrobial and anti-inflammatory activity against P. acnes is therefore of interest. In this study, we investigated the inhibitory effect of rosemary (Rosmarinus officinalis) extract on P. acnes-induced inflammation in vitro and in vivo. The results showed that ethanolic rosemary extract (ERE) significantly suppressed the secretion and mRNA expression of proinflammatory cytokines, including interleukin (IL)-8, IL-1β, and tumor necrosis factor-α in P. acnes-stimulated monocytic THP-1 cells. In an in vivo mouse model, concomitant intradermal injection of ERE attenuated the P. acnes-induced ear swelling and granulomatous inflammation. Since ERE suppressed the P. acnes-induced nuclear factor kappa-B (NF-κB) activation and mRNA expression of Toll-like receptor (TLR) 2, the suppressive effect of ERE might be due, at least partially, to diminished NF-κB activation and TLR2-mediated signaling pathways. Furthermore, three major constituents of ERE, carnosol, carnosic acid, and rosmarinic acid, exerted different immumodulatory activities in vitro. In brief, rosmarinic acid significantly suppressed IL-8 production, while the other two compounds inhibited IL-1β production. Further study is needed to explore the role of bioactive compounds of rosemary in mitigation of P. acnes-induced inflammation. SN - 1557-7600 UR - https://www.unboundmedicine.com/medline/citation/23514231/Rosmarinus_officinalis_extract_suppresses_Propionibacterium_acnes_induced_inflammatory_responses_ L2 - https://www.liebertpub.com/doi/10.1089/jmf.2012.2577?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -