Tags

Type your tag names separated by a space and hit enter

Intake of fiber and fiber-rich plant foods is associated with a lower risk of renal cell carcinoma in a large US cohort.
Am J Clin Nutr 2013; 97(5):1036-43AJ

Abstract

BACKGROUND

Plant-based and fiber-rich diets high in vegetables, fruit, and whole grains are recommended to prevent cancer and chronic conditions associated with renal cell carcinoma (RCC), such as obesity, hypertension, and diabetes. Diet may play a role in the etiology of RCC directly and/or indirectly.

OBJECTIVE

In a large prospective cohort of US men and women, we comprehensively investigated dietary intake and food sources of fiber in relation to RCC risk.

DESIGN

Participants of the NIH-AARP Diet and Health Study (n = 491,841) completed a self-administered questionnaire of demographics, diet, lifestyle, and medical history. Over 9 (mean) years of follow-up we identified 1816 incident cases of RCC. HRs and 95% CIs were estimated within quintiles by using multivariable Cox proportional hazards regression.

RESULTS

Total dietary fiber intake was associated with a significant 15-20% lower risk of RCC in the 2 highest quintiles compared with the lowest (P-trend = 0.005). Intakes of legumes, whole grains, and cruciferous vegetables were also associated with a 16-18% reduced risk of RCC. Conversely, refined grain intake was positively associated with RCC risk in a comparison of quintile 5 with quintile 1 (HR: 1.19; 95% CI: 1.02, 1.39; P-trend = 0.04). The inverse association between fiber intake and RCC was consistent among participants who never smoked, had a body mass index [BMI (in kg/m(2))] <30, and did not report a history of diabetes or hypertension.

CONCLUSIONS

Intake of fiber and fiber-rich plant foods was associated with a significantly lower risk of RCC in this large US cohort. This trial was registered at clinicaltrials.gov as NCT00340015.

Authors+Show Affiliations

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. cdaniel@mdanderson.org

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

23515007

Citation

Daniel, Carrie R., et al. "Intake of Fiber and Fiber-rich Plant Foods Is Associated With a Lower Risk of Renal Cell Carcinoma in a Large US Cohort." The American Journal of Clinical Nutrition, vol. 97, no. 5, 2013, pp. 1036-43.
Daniel CR, Park Y, Chow WH, et al. Intake of fiber and fiber-rich plant foods is associated with a lower risk of renal cell carcinoma in a large US cohort. Am J Clin Nutr. 2013;97(5):1036-43.
Daniel, C. R., Park, Y., Chow, W. H., Graubard, B. I., Hollenbeck, A. R., & Sinha, R. (2013). Intake of fiber and fiber-rich plant foods is associated with a lower risk of renal cell carcinoma in a large US cohort. The American Journal of Clinical Nutrition, 97(5), pp. 1036-43. doi:10.3945/ajcn.112.045351.
Daniel CR, et al. Intake of Fiber and Fiber-rich Plant Foods Is Associated With a Lower Risk of Renal Cell Carcinoma in a Large US Cohort. Am J Clin Nutr. 2013;97(5):1036-43. PubMed PMID: 23515007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of fiber and fiber-rich plant foods is associated with a lower risk of renal cell carcinoma in a large US cohort. AU - Daniel,Carrie R, AU - Park,Yikyung, AU - Chow,Wong-Ho, AU - Graubard,Barry I, AU - Hollenbeck,Albert R, AU - Sinha,Rashmi, Y1 - 2013/03/20/ PY - 2013/3/22/entrez PY - 2013/3/22/pubmed PY - 2013/6/19/medline SP - 1036 EP - 43 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 97 IS - 5 N2 - BACKGROUND: Plant-based and fiber-rich diets high in vegetables, fruit, and whole grains are recommended to prevent cancer and chronic conditions associated with renal cell carcinoma (RCC), such as obesity, hypertension, and diabetes. Diet may play a role in the etiology of RCC directly and/or indirectly. OBJECTIVE: In a large prospective cohort of US men and women, we comprehensively investigated dietary intake and food sources of fiber in relation to RCC risk. DESIGN: Participants of the NIH-AARP Diet and Health Study (n = 491,841) completed a self-administered questionnaire of demographics, diet, lifestyle, and medical history. Over 9 (mean) years of follow-up we identified 1816 incident cases of RCC. HRs and 95% CIs were estimated within quintiles by using multivariable Cox proportional hazards regression. RESULTS: Total dietary fiber intake was associated with a significant 15-20% lower risk of RCC in the 2 highest quintiles compared with the lowest (P-trend = 0.005). Intakes of legumes, whole grains, and cruciferous vegetables were also associated with a 16-18% reduced risk of RCC. Conversely, refined grain intake was positively associated with RCC risk in a comparison of quintile 5 with quintile 1 (HR: 1.19; 95% CI: 1.02, 1.39; P-trend = 0.04). The inverse association between fiber intake and RCC was consistent among participants who never smoked, had a body mass index [BMI (in kg/m(2))] <30, and did not report a history of diabetes or hypertension. CONCLUSIONS: Intake of fiber and fiber-rich plant foods was associated with a significantly lower risk of RCC in this large US cohort. This trial was registered at clinicaltrials.gov as NCT00340015. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/23515007/Intake_of_fiber_and_fiber_rich_plant_foods_is_associated_with_a_lower_risk_of_renal_cell_carcinoma_in_a_large_US_cohort_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.045351 DB - PRIME DP - Unbound Medicine ER -