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Will dengue vaccines be used in the public sector and if so, how? Findings from an 8-country survey of policymakers and opinion leaders.
PLoS Negl Trop Dis. 2013; 7(3):e2127.PN

Abstract

BACKGROUND

A face-to-face survey of 158 policymakers and other influential professionals was conducted in eight dengue-endemic countries in Asia (India, Sri Lanka, Thailand, Vietnam) and Latin America (Brazil, Colombia, Mexico, Nicaragua) to provide an indication of the potential demand for dengue vaccination in endemic countries, and to anticipate their research and other requirements in order to make decisions about the introduction of dengue vaccines. The study took place in anticipation of the licensure of the first dengue vaccine in the next several years.

METHODS/PRINCIPAL FINDINGS

Semi-structured interviews were conducted on an individual or small group basis with government health officials, research scientists, medical association officers, vaccine producers, local-level health authorities, and others considered to have a role in influencing decisions about dengue control and vaccines. Most informants across countries considered dengue a priority disease and expressed interest in the public sector use of dengue vaccines, with a major driver being the political pressure from the public and the medical community to control the disease. There was interest in a vaccine that protects children as young as possible and that can fit into existing childhood immunization schedules. Dengue vaccination in most countries surveyed will likely be targeted to high-risk areas and begin with routine immunization of infants and young children, followed by catch-up campaigns for older age groups, as funding permits. Key data requirements for decision-making were additional local dengue surveillance data, vaccine cost-effectiveness estimates, post-marketing safety surveillance data and, in some countries vaccine safety and immunogenicity data in the local population.

CONCLUSIONS/SIGNIFICANCE

The lookout for the public sector use of dengue vaccines in the eight countries appears quite favorable. Major determinants of whether and when countries will introduce dengue vaccines include whether WHO recommends the vaccines, their price, the availability of external financing for lower income countries, and whether they can be incorporated into countries' routine immunization schedules.

Authors+Show Affiliations

DKT Janani, Reshmi Complex, P&T Colony, Kidwaipuri, Patna, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23516658

Citation

Douglas, Don L., et al. "Will Dengue Vaccines Be Used in the Public Sector and if So, How? Findings From an 8-country Survey of Policymakers and Opinion Leaders." PLoS Neglected Tropical Diseases, vol. 7, no. 3, 2013, pp. e2127.
Douglas DL, DeRoeck DA, Mahoney RT, et al. Will dengue vaccines be used in the public sector and if so, how? Findings from an 8-country survey of policymakers and opinion leaders. PLoS Negl Trop Dis. 2013;7(3):e2127.
Douglas, D. L., DeRoeck, D. A., Mahoney, R. T., & Wichmann, O. (2013). Will dengue vaccines be used in the public sector and if so, how? Findings from an 8-country survey of policymakers and opinion leaders. PLoS Neglected Tropical Diseases, 7(3), e2127. https://doi.org/10.1371/journal.pntd.0002127
Douglas DL, et al. Will Dengue Vaccines Be Used in the Public Sector and if So, How? Findings From an 8-country Survey of Policymakers and Opinion Leaders. PLoS Negl Trop Dis. 2013;7(3):e2127. PubMed PMID: 23516658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Will dengue vaccines be used in the public sector and if so, how? Findings from an 8-country survey of policymakers and opinion leaders. AU - Douglas,Don L, AU - DeRoeck,Denise A, AU - Mahoney,Richard T, AU - Wichmann,Ole, Y1 - 2013/03/14/ PY - 2012/06/18/received PY - 2013/02/08/accepted PY - 2013/3/22/entrez PY - 2013/3/22/pubmed PY - 2013/8/29/medline SP - e2127 EP - e2127 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 7 IS - 3 N2 - BACKGROUND: A face-to-face survey of 158 policymakers and other influential professionals was conducted in eight dengue-endemic countries in Asia (India, Sri Lanka, Thailand, Vietnam) and Latin America (Brazil, Colombia, Mexico, Nicaragua) to provide an indication of the potential demand for dengue vaccination in endemic countries, and to anticipate their research and other requirements in order to make decisions about the introduction of dengue vaccines. The study took place in anticipation of the licensure of the first dengue vaccine in the next several years. METHODS/PRINCIPAL FINDINGS: Semi-structured interviews were conducted on an individual or small group basis with government health officials, research scientists, medical association officers, vaccine producers, local-level health authorities, and others considered to have a role in influencing decisions about dengue control and vaccines. Most informants across countries considered dengue a priority disease and expressed interest in the public sector use of dengue vaccines, with a major driver being the political pressure from the public and the medical community to control the disease. There was interest in a vaccine that protects children as young as possible and that can fit into existing childhood immunization schedules. Dengue vaccination in most countries surveyed will likely be targeted to high-risk areas and begin with routine immunization of infants and young children, followed by catch-up campaigns for older age groups, as funding permits. Key data requirements for decision-making were additional local dengue surveillance data, vaccine cost-effectiveness estimates, post-marketing safety surveillance data and, in some countries vaccine safety and immunogenicity data in the local population. CONCLUSIONS/SIGNIFICANCE: The lookout for the public sector use of dengue vaccines in the eight countries appears quite favorable. Major determinants of whether and when countries will introduce dengue vaccines include whether WHO recommends the vaccines, their price, the availability of external financing for lower income countries, and whether they can be incorporated into countries' routine immunization schedules. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/23516658/Will_dengue_vaccines_be_used_in_the_public_sector_and_if_so_how_Findings_from_an_8_country_survey_of_policymakers_and_opinion_leaders_ L2 - https://dx.plos.org/10.1371/journal.pntd.0002127 DB - PRIME DP - Unbound Medicine ER -