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Chemical composition and antifungal activity of Matricaria recutita flower essential oil against medically important dermatophytes and soil-borne pathogens.
J Mycol Med. 2012 Dec; 22(4):308-15.JM

Abstract

OBJECTIVE

Fungal infections are potential public health threats all over the world. In the present study, effect of Matricaria recutita flower essential oil (EO) was evaluated against medically important dermatophytes and opportunistic saprophytes using microbioassay technique.

MATERIALS AND METHODS

Flower essential oil (EO) of M. recutita prepared by hydrodistillation was analyzed by gas chromatography/mass spectrometry (GC/MS). The effect of plant EO on the growth of pathogenic dermatophytes and opportunistic saprophytes was assessed using microbioassay technique. In the bioassay, fungi were cultured in 6-well flat-bottom microplates in presence of various concentrations of plant EO (2.5-1000μg/mL) for 4-10days at 28°C.

RESULTS

A total of 14 compounds were identified in the plant oil by GC/MS accounting for 97.5% of the oil composition. The main compound identified was chamazulene (61.3%) followed by isopropyl hexadecanoate (12.7%), trans-trans-farnesol (6.9%) and E-β-farnesol (5.2%). Growth inhibition for the dermatophytes exposed to serial two-fold concentrations of plant EO (2.5 to 80μg/mL) was reported in the range of 3.24 to 68.15% for Microsporum gypseum, 24.48 to 100% for M. canis, 11.40 to 96.65% for Trichophyton mentagrophytes, 27.79 to 100% for T. rubrum and 45.73 to 100% for T. tonsurans. M. recutita EO inhibited the growth of opportunistic saprophytes by 3.98 to 64.29% for Aspergillus flavus, 6.38 to 93.62% for A. fumigatus, 3.52 to 89.45% for A. niger, 6.38 to 77.66% for Trichoderma harzianum and 17.41 to 89.41% for Fusarium oxysporum in serial two-fold concentrations of 15.62 to 1000μg/mL.

CONCLUSION

Results of the present study indicate that M. recutita could be considered as a potential candidate for designing effective antifungal formulations suitable for treatment of dermatophytosis and other fungal infections.

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Publisher Full Text

Authors+Show Affiliations

Jamalian A
Department of Mycology, Pasteur Institute of Iran, 13164 Tehran, Iran.
Shams-Ghahfarokhi M
No affiliation info available
Jaimand K
No affiliation info available
Pashootan N
No affiliation info available
Amani A
No affiliation info available
Razzaghi-Abyaneh M
No affiliation info available

MeSH

Antifungal AgentsAspergillusAzulenesDistillationDrug Evaluation, PreclinicalFarnesolFlowersFoeniculumGas Chromatography-Mass SpectrometryHypericumMatricariaMicrobial Sensitivity TestsMicrosporumOils, VolatilePalmitatesPlant LeavesPlant RootsSoil MicrobiologyTrichophyton

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23518164

Citation

Jamalian, A, et al. "Chemical Composition and Antifungal Activity of Matricaria Recutita Flower Essential Oil Against Medically Important Dermatophytes and Soil-borne Pathogens." Journal De Mycologie Medicale, vol. 22, no. 4, 2012, pp. 308-15.
Jamalian A, Shams-Ghahfarokhi M, Jaimand K, et al. Chemical composition and antifungal activity of Matricaria recutita flower essential oil against medically important dermatophytes and soil-borne pathogens. J Mycol Med. 2012;22(4):308-15.
Jamalian, A., Shams-Ghahfarokhi, M., Jaimand, K., Pashootan, N., Amani, A., & Razzaghi-Abyaneh, M. (2012). Chemical composition and antifungal activity of Matricaria recutita flower essential oil against medically important dermatophytes and soil-borne pathogens. Journal De Mycologie Medicale, 22(4), 308-15. https://doi.org/10.1016/j.mycmed.2012.09.003
Jamalian A, et al. Chemical Composition and Antifungal Activity of Matricaria Recutita Flower Essential Oil Against Medically Important Dermatophytes and Soil-borne Pathogens. J Mycol Med. 2012;22(4):308-15. PubMed PMID: 23518164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical composition and antifungal activity of Matricaria recutita flower essential oil against medically important dermatophytes and soil-borne pathogens. AU - Jamalian,A, AU - Shams-Ghahfarokhi,M, AU - Jaimand,K, AU - Pashootan,N, AU - Amani,A, AU - Razzaghi-Abyaneh,M, Y1 - 2012/10/23/ PY - 2012/07/13/received PY - 2012/09/05/revised PY - 2012/09/12/accepted PY - 2013/3/23/entrez PY - 2013/3/23/pubmed PY - 2014/4/5/medline SP - 308 EP - 15 JF - Journal de mycologie medicale JO - J Mycol Med VL - 22 IS - 4 N2 - OBJECTIVE: Fungal infections are potential public health threats all over the world. In the present study, effect of Matricaria recutita flower essential oil (EO) was evaluated against medically important dermatophytes and opportunistic saprophytes using microbioassay technique. MATERIALS AND METHODS: Flower essential oil (EO) of M. recutita prepared by hydrodistillation was analyzed by gas chromatography/mass spectrometry (GC/MS). The effect of plant EO on the growth of pathogenic dermatophytes and opportunistic saprophytes was assessed using microbioassay technique. In the bioassay, fungi were cultured in 6-well flat-bottom microplates in presence of various concentrations of plant EO (2.5-1000μg/mL) for 4-10days at 28°C. RESULTS: A total of 14 compounds were identified in the plant oil by GC/MS accounting for 97.5% of the oil composition. The main compound identified was chamazulene (61.3%) followed by isopropyl hexadecanoate (12.7%), trans-trans-farnesol (6.9%) and E-β-farnesol (5.2%). Growth inhibition for the dermatophytes exposed to serial two-fold concentrations of plant EO (2.5 to 80μg/mL) was reported in the range of 3.24 to 68.15% for Microsporum gypseum, 24.48 to 100% for M. canis, 11.40 to 96.65% for Trichophyton mentagrophytes, 27.79 to 100% for T. rubrum and 45.73 to 100% for T. tonsurans. M. recutita EO inhibited the growth of opportunistic saprophytes by 3.98 to 64.29% for Aspergillus flavus, 6.38 to 93.62% for A. fumigatus, 3.52 to 89.45% for A. niger, 6.38 to 77.66% for Trichoderma harzianum and 17.41 to 89.41% for Fusarium oxysporum in serial two-fold concentrations of 15.62 to 1000μg/mL. CONCLUSION: Results of the present study indicate that M. recutita could be considered as a potential candidate for designing effective antifungal formulations suitable for treatment of dermatophytosis and other fungal infections. SN - 1773-0449 UR - https://www.unboundmedicine.com/medline/citation/23518164/Chemical_composition_and_antifungal_activity_of_Matricaria_recutita_flower_essential_oil_against_medically_important_dermatophytes_and_soil_borne_pathogens_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1156-5233(12)00147-3 DB - PRIME DP - Unbound Medicine ER -