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Lupane-type triterpenoidal saponins from Pulsatilla chinensis and their anticomplement activities through the classical pathway.
Planta Med. 2013 Apr; 79(6):506-12.PM

Abstract

Four (1-4) previously unknown lupane-type triterpenoidal saponins were isolated from the roots of Pulsatilla chinensis, along with six triterpene saponins (5-10). The structures of saponins 1-4 were determined as 23-hydroxy-3β-[(O-β-D-glucopyranosyl-(1 → 4)-α-L-arabinopyranosyl)]lup-20(29)-en-28-oic-acid 28-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (1), 23-hydroxy-3β-[(O-α-L-rhamnopyranosyl-(1 → 2)-[β-D-glucopyranosyl-(1 → 4)]-α-L-arabinopyranosyl)]lup-20(29)-en-28-oic-acid 28-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (2), 3β-[(O-β-D-glucopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranosyl)]lup-20(29)-en-28-oic-acid 28-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (3), and 3β-[(O-β-D-glucopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranosyl)]lup-20(29)-en-28-oic-acid 28-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (4), on the basis of hydrolysis and spectral evidence, including 1D- and 2D-NMR and HR-ESI-MS analyses. These pure isolates (1-10) were tested for their anticomplement activity, using an in vitro assay of the complement system of the classical pathway.

Authors+Show Affiliations

College of Pharmaceutical Science, Soochow University, Suzhou, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23519791

Citation

Xu, Qiong-ming, et al. "Lupane-type Triterpenoidal Saponins From Pulsatilla Chinensis and Their Anticomplement Activities Through the Classical Pathway." Planta Medica, vol. 79, no. 6, 2013, pp. 506-12.
Xu QM, Shu Z, Zhu WF, et al. Lupane-type triterpenoidal saponins from Pulsatilla chinensis and their anticomplement activities through the classical pathway. Planta Med. 2013;79(6):506-12.
Xu, Q. M., Shu, Z., Zhu, W. F., Liu, Y. L., Li, X. R., & Yang, S. L. (2013). Lupane-type triterpenoidal saponins from Pulsatilla chinensis and their anticomplement activities through the classical pathway. Planta Medica, 79(6), 506-12. https://doi.org/10.1055/s-0032-1328323
Xu QM, et al. Lupane-type Triterpenoidal Saponins From Pulsatilla Chinensis and Their Anticomplement Activities Through the Classical Pathway. Planta Med. 2013;79(6):506-12. PubMed PMID: 23519791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lupane-type triterpenoidal saponins from Pulsatilla chinensis and their anticomplement activities through the classical pathway. AU - Xu,Qiong-ming, AU - Shu,Zhan, AU - Zhu,Wei-feng, AU - Liu,Yan-li, AU - Li,Xiao-ran, AU - Yang,Shi-lin, Y1 - 2013/03/21/ PY - 2013/3/23/entrez PY - 2013/3/23/pubmed PY - 2013/11/7/medline SP - 506 EP - 12 JF - Planta medica JO - Planta Med VL - 79 IS - 6 N2 - Four (1-4) previously unknown lupane-type triterpenoidal saponins were isolated from the roots of Pulsatilla chinensis, along with six triterpene saponins (5-10). The structures of saponins 1-4 were determined as 23-hydroxy-3β-[(O-β-D-glucopyranosyl-(1 → 4)-α-L-arabinopyranosyl)]lup-20(29)-en-28-oic-acid 28-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (1), 23-hydroxy-3β-[(O-α-L-rhamnopyranosyl-(1 → 2)-[β-D-glucopyranosyl-(1 → 4)]-α-L-arabinopyranosyl)]lup-20(29)-en-28-oic-acid 28-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (2), 3β-[(O-β-D-glucopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranosyl)]lup-20(29)-en-28-oic-acid 28-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (3), and 3β-[(O-β-D-glucopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranosyl)]lup-20(29)-en-28-oic-acid 28-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (4), on the basis of hydrolysis and spectral evidence, including 1D- and 2D-NMR and HR-ESI-MS analyses. These pure isolates (1-10) were tested for their anticomplement activity, using an in vitro assay of the complement system of the classical pathway. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/23519791/Lupane_type_triterpenoidal_saponins_from_Pulsatilla_chinensis_and_their_anticomplement_activities_through_the_classical_pathway_ DB - PRIME DP - Unbound Medicine ER -