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Homage to Rita Levi-Montalcini, the queen of modern neuroscience.
Cell Biol Int 2013; 37(8):761-5CB

Abstract

The first cell growth factor, nerve growth factor (NGF), was discovered by Rita Levi-Montalcini (RLM) in the early 1950s. Originally identified as neurite outgrowth-stimulating factor, later studies revealed that non-neuronal cells, including immune cells, endothelial cells, cardiomyocytes, pancreatic beta cells, prostate epithelial and adipose tissue cells, were also targets for and/or sources of NGF. Nerve growth factor is well recognised as mediating multiple biological phenomena, ranging from the neurotrophic through immunotrophic and epitheliotrophic to metabotrophic effects. Consequently, NGF and other members of the neurotrophin family are implicated in the pathogenesis of a large spectrum of neuronal and non-neuronal diseases, ranging from Alzheimer's and other neurodegenerative diseases to atherosclerosis and cardiometabolic disorders. Recent studies have demonstrated the therapeutic potentials of NGF in these conditions, including ocular and cutaneous diseases. NGF TrkA receptor antagonists emerged as novel drugs for pain, prostate and breast cancer, melanoma and urinary bladder syndromes. Here, we briefly describe the 'unpredictable' ideogenesis of the discovery of NGF, a eureka in the neuroscience.

Authors+Show Affiliations

Institute of Cell Biology and Neurobiology, National Research Council (CNR), Rome, Italy. aloe@inmm.cnr.itNo affiliation info available

Pub Type(s)

Biography
Historical Article
Journal Article
Portrait

Language

eng

PubMed ID

23520136

Citation

Aloe, Luigi, and George N. Chaldakov. "Homage to Rita Levi-Montalcini, the Queen of Modern Neuroscience." Cell Biology International, vol. 37, no. 8, 2013, pp. 761-5.
Aloe L, Chaldakov GN. Homage to Rita Levi-Montalcini, the queen of modern neuroscience. Cell Biol Int. 2013;37(8):761-5.
Aloe, L., & Chaldakov, G. N. (2013). Homage to Rita Levi-Montalcini, the queen of modern neuroscience. Cell Biology International, 37(8), pp. 761-5. doi:10.1002/cbin.10098.
Aloe L, Chaldakov GN. Homage to Rita Levi-Montalcini, the Queen of Modern Neuroscience. Cell Biol Int. 2013;37(8):761-5. PubMed PMID: 23520136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homage to Rita Levi-Montalcini, the queen of modern neuroscience. AU - Aloe,Luigi, AU - Chaldakov,George N, Y1 - 2013/05/03/ PY - 2013/02/27/received PY - 2013/03/11/accepted PY - 2013/3/23/entrez PY - 2013/3/23/pubmed PY - 2014/1/28/medline KW - TrkA KW - disease KW - nerve growth factor KW - neuronal cells KW - non-neuronal cells KW - p75NTR SP - 761 EP - 5 JF - Cell biology international JO - Cell Biol. Int. VL - 37 IS - 8 N2 - The first cell growth factor, nerve growth factor (NGF), was discovered by Rita Levi-Montalcini (RLM) in the early 1950s. Originally identified as neurite outgrowth-stimulating factor, later studies revealed that non-neuronal cells, including immune cells, endothelial cells, cardiomyocytes, pancreatic beta cells, prostate epithelial and adipose tissue cells, were also targets for and/or sources of NGF. Nerve growth factor is well recognised as mediating multiple biological phenomena, ranging from the neurotrophic through immunotrophic and epitheliotrophic to metabotrophic effects. Consequently, NGF and other members of the neurotrophin family are implicated in the pathogenesis of a large spectrum of neuronal and non-neuronal diseases, ranging from Alzheimer's and other neurodegenerative diseases to atherosclerosis and cardiometabolic disorders. Recent studies have demonstrated the therapeutic potentials of NGF in these conditions, including ocular and cutaneous diseases. NGF TrkA receptor antagonists emerged as novel drugs for pain, prostate and breast cancer, melanoma and urinary bladder syndromes. Here, we briefly describe the 'unpredictable' ideogenesis of the discovery of NGF, a eureka in the neuroscience. SN - 1095-8355 UR - https://www.unboundmedicine.com/medline/citation/23520136/Homage_to_Rita_Levi-Montalcini,_the_queen_of_modern_neuroscience L2 - https://doi.org/10.1002/cbin.10098 DB - PRIME DP - Unbound Medicine ER -