Tags

Type your tag names separated by a space and hit enter

Serum magnesium in the metabolically-obese normal-weight and healthy-obese subjects.
Eur J Intern Med. 2013 Oct; 24(7):639-43.EJ

Abstract

BACKGROUND

Given that hypomagnesemia is related with hyperglycemia, hypertension, hypertriglyceridemia, and insulin resistance, the objective of this study was to determine whether serum magnesium levels are associated with the metabolically obese normal weight (MONW) and the metabolically healthy obese (MHO) phenotypes.

METHODS

Population-based cross-sectional study that enrolled 427 subjects, men and non-pregnant women aged 20 to 65years, to participate in the study. Subjects were allocated into groups with and without obesity; among non-obese individuals, the subgroup of MONW subjects was compared with a control group of healthy normal-weight individuals. Among obese individuals, the subgroup of MHO subjects was compared with a control group of obese subjects who exhibited at least one metabolic abnormality. In the absence of obesity, the presence of fasting hyperglycemia, insulin resistance, hypertriglyceridemia, and/or hypertension defined the presence of MONW phenotype. In the absence of hypertension, insulin resistance and metabolic abnormalities of fasting glucose and triglycerides levels, the phenotypically obese subjects were defined as MHO individuals.

RESULTS

The sex-adjusted prevalence of MONW and MHO phenotypes was 40.8% and 27.9%. The multivariate logistic regression model adjusted by family history of diabetes, age, body mass index, and waist-circumference, showed a positive association between hypomagnesemia and the MONW phenotype (OR 6.4; 95%CI 2.3-20.4) and negative relationship between serum magnesium and the MHO phenotype (OR 0.32; 95%CI 0.17-0.61).

CONCLUSIONS

Our results show that hypomagnesemia is positively associated with the presence of MONW phenotype, and the normomagnesemia negatively with the MHO phenotype.

Authors+Show Affiliations

Biomedical Research Unit, Mexican Social Security Institute, Predio Canoas # 100, Col. Los Angeles, ZC 34067, Durango, Mexico.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23523313

Citation

Guerrero-Romero, Fernando, and Martha Rodriguez-Moran. "Serum Magnesium in the Metabolically-obese Normal-weight and Healthy-obese Subjects." European Journal of Internal Medicine, vol. 24, no. 7, 2013, pp. 639-43.
Guerrero-Romero F, Rodriguez-Moran M. Serum magnesium in the metabolically-obese normal-weight and healthy-obese subjects. Eur J Intern Med. 2013;24(7):639-43.
Guerrero-Romero, F., & Rodriguez-Moran, M. (2013). Serum magnesium in the metabolically-obese normal-weight and healthy-obese subjects. European Journal of Internal Medicine, 24(7), 639-43. https://doi.org/10.1016/j.ejim.2013.02.014
Guerrero-Romero F, Rodriguez-Moran M. Serum Magnesium in the Metabolically-obese Normal-weight and Healthy-obese Subjects. Eur J Intern Med. 2013;24(7):639-43. PubMed PMID: 23523313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum magnesium in the metabolically-obese normal-weight and healthy-obese subjects. AU - Guerrero-Romero,Fernando, AU - Rodriguez-Moran,Martha, Y1 - 2013/03/20/ PY - 2012/12/20/received PY - 2013/02/21/revised PY - 2013/02/25/accepted PY - 2013/3/26/entrez PY - 2013/3/26/pubmed PY - 2014/4/29/medline KW - Hypomagnesemia KW - Magnesium KW - Metabolically healthy obese KW - Metabolically obese normal weight SP - 639 EP - 43 JF - European journal of internal medicine JO - Eur J Intern Med VL - 24 IS - 7 N2 - BACKGROUND: Given that hypomagnesemia is related with hyperglycemia, hypertension, hypertriglyceridemia, and insulin resistance, the objective of this study was to determine whether serum magnesium levels are associated with the metabolically obese normal weight (MONW) and the metabolically healthy obese (MHO) phenotypes. METHODS: Population-based cross-sectional study that enrolled 427 subjects, men and non-pregnant women aged 20 to 65years, to participate in the study. Subjects were allocated into groups with and without obesity; among non-obese individuals, the subgroup of MONW subjects was compared with a control group of healthy normal-weight individuals. Among obese individuals, the subgroup of MHO subjects was compared with a control group of obese subjects who exhibited at least one metabolic abnormality. In the absence of obesity, the presence of fasting hyperglycemia, insulin resistance, hypertriglyceridemia, and/or hypertension defined the presence of MONW phenotype. In the absence of hypertension, insulin resistance and metabolic abnormalities of fasting glucose and triglycerides levels, the phenotypically obese subjects were defined as MHO individuals. RESULTS: The sex-adjusted prevalence of MONW and MHO phenotypes was 40.8% and 27.9%. The multivariate logistic regression model adjusted by family history of diabetes, age, body mass index, and waist-circumference, showed a positive association between hypomagnesemia and the MONW phenotype (OR 6.4; 95%CI 2.3-20.4) and negative relationship between serum magnesium and the MHO phenotype (OR 0.32; 95%CI 0.17-0.61). CONCLUSIONS: Our results show that hypomagnesemia is positively associated with the presence of MONW phenotype, and the normomagnesemia negatively with the MHO phenotype. SN - 1879-0828 UR - https://www.unboundmedicine.com/medline/citation/23523313/Serum_magnesium_in_the_metabolically_obese_normal_weight_and_healthy_obese_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0953-6205(13)00080-0 DB - PRIME DP - Unbound Medicine ER -