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Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients.
Clin Neurol Neurosurg. 2013 Sep; 115(9):1657-60.CN

Abstract

BACKGROUND AND OBJECTIVE

Multiple sclerosis (MS) is a chronic neurological disease characterized by central nervous system (CNS) inflammation and demyelination of nerve axons. The aim of this study was to investigate a possible association between the methylenetetrahydrofolate reductase (MTHFR) gene and multiple sclerosis in Tunisian patients.

PATIENTS AND METHODS

The genotyping of two missense variants of the methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C was performed in 80 multiple sclerosis patients and 200 healthy controls.

RESULTS

No significant differences were found in the frequency of the MTHFR C677T polymorphism between MS patients and healthy controls. However, the genotype prevalence of the missense variant MTHFR A1298C was significantly different between patients and controls (A/C: 55% versus 7%, p<10(-3); C/C: 13.75% versus 0%, p<10(-3), respectively).

CONCLUSION

Although our preliminary findings suggest no association between the MTHFR C677T variants and MS, there is evidence to suggest a significant association between the MTHFR A1298C polymorphisms and MS.

Authors+Show Affiliations

Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunisia, Tunis, Tunisia. fnajiba@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23523621

Citation

Fekih Mrissa, Najiba, et al. "Association of Methylenetetrahydrofolate Reductase A1298C Polymorphism but Not of C677T With Multiple Sclerosis in Tunisian Patients." Clinical Neurology and Neurosurgery, vol. 115, no. 9, 2013, pp. 1657-60.
Fekih Mrissa N, Mrad M, Klai S, et al. Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients. Clin Neurol Neurosurg. 2013;115(9):1657-60.
Fekih Mrissa, N., Mrad, M., Klai, S., Zaouali, J., Sayeh, A., Mazigh, C., Nsiri, B., Machgoul, S., Gritli, N., & Mrissa, R. (2013). Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients. Clinical Neurology and Neurosurgery, 115(9), 1657-60. https://doi.org/10.1016/j.clineuro.2013.02.025
Fekih Mrissa N, et al. Association of Methylenetetrahydrofolate Reductase A1298C Polymorphism but Not of C677T With Multiple Sclerosis in Tunisian Patients. Clin Neurol Neurosurg. 2013;115(9):1657-60. PubMed PMID: 23523621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients. AU - Fekih Mrissa,Najiba, AU - Mrad,Meriem, AU - Klai,Sarra, AU - Zaouali,Jamel, AU - Sayeh,Aycha, AU - Mazigh,Chakib, AU - Nsiri,Brahim, AU - Machgoul,Salem, AU - Gritli,Nasreddine, AU - Mrissa,Ridha, Y1 - 2013/03/21/ PY - 2012/04/26/received PY - 2012/11/14/revised PY - 2013/02/23/accepted PY - 2013/3/26/entrez PY - 2013/3/26/pubmed PY - 2014/4/3/medline KW - Methylenetetrahydrofolate reductase polymorphism KW - Multiple sclerosis SP - 1657 EP - 60 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 115 IS - 9 N2 - BACKGROUND AND OBJECTIVE: Multiple sclerosis (MS) is a chronic neurological disease characterized by central nervous system (CNS) inflammation and demyelination of nerve axons. The aim of this study was to investigate a possible association between the methylenetetrahydrofolate reductase (MTHFR) gene and multiple sclerosis in Tunisian patients. PATIENTS AND METHODS: The genotyping of two missense variants of the methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C was performed in 80 multiple sclerosis patients and 200 healthy controls. RESULTS: No significant differences were found in the frequency of the MTHFR C677T polymorphism between MS patients and healthy controls. However, the genotype prevalence of the missense variant MTHFR A1298C was significantly different between patients and controls (A/C: 55% versus 7%, p<10(-3); C/C: 13.75% versus 0%, p<10(-3), respectively). CONCLUSION: Although our preliminary findings suggest no association between the MTHFR C677T variants and MS, there is evidence to suggest a significant association between the MTHFR A1298C polymorphisms and MS. SN - 1872-6968 UR - https://www.unboundmedicine.com/medline/citation/23523621/Association_of_methylenetetrahydrofolate_reductase_A1298C_polymorphism_but_not_of_C677T_with_multiple_sclerosis_in_Tunisian_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-8467(13)00088-7 DB - PRIME DP - Unbound Medicine ER -