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Strain differences in profiles of dopaminergic neurotransmission in the prefrontal cortex of the BALB/C vs. C57Bl/6 mice: consequences of stress and afobazole.
Eur J Pharmacol. 2013 May 15; 708(1-3):95-104.EJ

Abstract

We found that in mice the basal activity of monoamine oxidase B (MAO-B) in the medial prefrontal cortex (mPFC) is lower in BALB/C than in C57Bl/6J mice, whereas activity of MAO-A is similar between strains. BALB/C mice, in comparison to C57Bl/6N mice, have higher basal content of dopamine in the mPFC, in both microdialysates and tissue content. Novelty stress (open field test) elicits a further increase in the microdialysate levels of dopamine in BALB/C, but not in C57Bl/6N mice; a subsequent accumulation of extracellular 3,4-dioxyphenylacetic acid (DOPAC) reaffirms the difference in catabolic capacity of monoaminergic systems between the strains. We demonstrated that in stress-susceptible BALB/C mice the novel anxiolytic afobazole, 5mg/kg, selectively mitigates trait anxiety; however it does not change the behavioral response in stress-resilient C57Bl/6N mice. Afobazole inhibits MAO-A in in vitro; it also lowers the microdialysate DOPAC levels in both strains (which testifies to its MAO-A inhibiting activity in vivo) and slightly suppresses dopamine release when elevated. Therefore, it is likely that the drug may mediate its anxiolytic activity via modulation of volume dopaminergic transmission at level of the mPFC.

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Authors+Show Affiliations

Anderzhanova EA
Max Planck Institute Psychiatry, Max-Planck-Gesellschaft, Kraepelinstrasse 2-10, 80804-D Munich, Germany. anderzhanova@mpipsykl.mpg.de
Bächli H
No affiliation info available
Buneeva OA
No affiliation info available
Narkevich VB
No affiliation info available
Medvedev AE
No affiliation info available
Thoeringer CK
No affiliation info available
Wotjak CT
No affiliation info available
Kudrin VS
No affiliation info available

MeSH

3,4-Dihydroxyphenylacetic AcidAnimalsAnti-Anxiety AgentsAnxietyBehavior, AnimalBenzimidazolesDopamineHomovanillic AcidHydroxyindoleacetic AcidMaleMiceMice, Inbred BALB CMice, Inbred C57BLMitochondriaMonoamine OxidaseMorpholinesPrefrontal CortexSpecies SpecificityStress, PsychologicalSynaptic Transmission

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23524098

Citation

Anderzhanova, Elmira A., et al. "Strain Differences in Profiles of Dopaminergic Neurotransmission in the Prefrontal Cortex of the BALB/C Vs. C57Bl/6 Mice: Consequences of Stress and Afobazole." European Journal of Pharmacology, vol. 708, no. 1-3, 2013, pp. 95-104.
Anderzhanova EA, Bächli H, Buneeva OA, et al. Strain differences in profiles of dopaminergic neurotransmission in the prefrontal cortex of the BALB/C vs. C57Bl/6 mice: consequences of stress and afobazole. Eur J Pharmacol. 2013;708(1-3):95-104.
Anderzhanova, E. A., Bächli, H., Buneeva, O. A., Narkevich, V. B., Medvedev, A. E., Thoeringer, C. K., Wotjak, C. T., & Kudrin, V. S. (2013). Strain differences in profiles of dopaminergic neurotransmission in the prefrontal cortex of the BALB/C vs. C57Bl/6 mice: consequences of stress and afobazole. European Journal of Pharmacology, 708(1-3), 95-104. https://doi.org/10.1016/j.ejphar.2013.03.015
Anderzhanova EA, et al. Strain Differences in Profiles of Dopaminergic Neurotransmission in the Prefrontal Cortex of the BALB/C Vs. C57Bl/6 Mice: Consequences of Stress and Afobazole. Eur J Pharmacol. 2013 May 15;708(1-3):95-104. PubMed PMID: 23524098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Strain differences in profiles of dopaminergic neurotransmission in the prefrontal cortex of the BALB/C vs. C57Bl/6 mice: consequences of stress and afobazole. AU - Anderzhanova,Elmira A, AU - Bächli,Heidi, AU - Buneeva,Olga A, AU - Narkevich,Victor B, AU - Medvedev,Alexei E, AU - Thoeringer,Christoph K, AU - Wotjak,Carsten T, AU - Kudrin,Vladimir S, Y1 - 2013/03/21/ PY - 2012/12/21/received PY - 2013/03/11/revised PY - 2013/03/13/accepted PY - 2013/3/26/entrez PY - 2013/3/26/pubmed PY - 2013/12/18/medline SP - 95 EP - 104 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 708 IS - 1-3 N2 - We found that in mice the basal activity of monoamine oxidase B (MAO-B) in the medial prefrontal cortex (mPFC) is lower in BALB/C than in C57Bl/6J mice, whereas activity of MAO-A is similar between strains. BALB/C mice, in comparison to C57Bl/6N mice, have higher basal content of dopamine in the mPFC, in both microdialysates and tissue content. Novelty stress (open field test) elicits a further increase in the microdialysate levels of dopamine in BALB/C, but not in C57Bl/6N mice; a subsequent accumulation of extracellular 3,4-dioxyphenylacetic acid (DOPAC) reaffirms the difference in catabolic capacity of monoaminergic systems between the strains. We demonstrated that in stress-susceptible BALB/C mice the novel anxiolytic afobazole, 5mg/kg, selectively mitigates trait anxiety; however it does not change the behavioral response in stress-resilient C57Bl/6N mice. Afobazole inhibits MAO-A in in vitro; it also lowers the microdialysate DOPAC levels in both strains (which testifies to its MAO-A inhibiting activity in vivo) and slightly suppresses dopamine release when elevated. Therefore, it is likely that the drug may mediate its anxiolytic activity via modulation of volume dopaminergic transmission at level of the mPFC. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/23524098/Strain_differences_in_profiles_of_dopaminergic_neurotransmission_in_the_prefrontal_cortex_of_the_BALB/C_vs__C57Bl/6_mice:_consequences_of_stress_and_afobazole_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(13)00205-7 DB - PRIME DP - Unbound Medicine ER -
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