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Pro-inflammatory cytokine predicts reduced rejection of unfair financial offers.
Neuro Endocrinol Lett. 2013; 34(1):47-51.NE

Abstract

OBJECTIVES

This study aimed to examine one of biological correlates, pro-inflammatory cytokine, in rejection of unfair financial offers in the Ultimatum Game (UG), where the division of a sum of money is proposed and the player can accept or reject this offer.

METHODS

Nineteen participants played 20 trials of the UG as responders, and they were proposed unfair offers in a half of the trials. Baseline levels of several pro-inflammatory and anti-inflammatory cytokines, subjective happiness, and depression of them were measured.

RESULTS

Participants with higher levels of the pro-inflammatory cytokine, interleukin (IL)-6 rejected fewer unfair offers. This effect of IL-6 levels on decision-making was independent from other pro-inflammatory cytokines, anti-inflammatory cytokines, subjective happiness, and depression.

CONCLUSIONS

These results suggested that chronic higher levels of IL-6 might affect functions of neural regions related to decision making, and thus can modulate rejection of unfair offers.

Authors+Show Affiliations

Department of Psychology, Nagoya University, Nagoya, Japan. ohira@lit.nagoya-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23524623

Citation

Ohira, Hideki, et al. "Pro-inflammatory Cytokine Predicts Reduced Rejection of Unfair Financial Offers." Neuro Endocrinology Letters, vol. 34, no. 1, 2013, pp. 47-51.
Ohira H, Osumi T, Matsunaga M, et al. Pro-inflammatory cytokine predicts reduced rejection of unfair financial offers. Neuro Endocrinol Lett. 2013;34(1):47-51.
Ohira, H., Osumi, T., Matsunaga, M., & Yamakawa, K. (2013). Pro-inflammatory cytokine predicts reduced rejection of unfair financial offers. Neuro Endocrinology Letters, 34(1), 47-51.
Ohira H, et al. Pro-inflammatory Cytokine Predicts Reduced Rejection of Unfair Financial Offers. Neuro Endocrinol Lett. 2013;34(1):47-51. PubMed PMID: 23524623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pro-inflammatory cytokine predicts reduced rejection of unfair financial offers. AU - Ohira,Hideki, AU - Osumi,Takahiro, AU - Matsunaga,Masahiro, AU - Yamakawa,Kaori, PY - 2012/12/08/received PY - 2013/01/17/accepted PY - 2013/3/26/entrez PY - 2013/3/26/pubmed PY - 2013/6/21/medline SP - 47 EP - 51 JF - Neuro endocrinology letters JO - Neuro Endocrinol Lett VL - 34 IS - 1 N2 - OBJECTIVES: This study aimed to examine one of biological correlates, pro-inflammatory cytokine, in rejection of unfair financial offers in the Ultimatum Game (UG), where the division of a sum of money is proposed and the player can accept or reject this offer. METHODS: Nineteen participants played 20 trials of the UG as responders, and they were proposed unfair offers in a half of the trials. Baseline levels of several pro-inflammatory and anti-inflammatory cytokines, subjective happiness, and depression of them were measured. RESULTS: Participants with higher levels of the pro-inflammatory cytokine, interleukin (IL)-6 rejected fewer unfair offers. This effect of IL-6 levels on decision-making was independent from other pro-inflammatory cytokines, anti-inflammatory cytokines, subjective happiness, and depression. CONCLUSIONS: These results suggested that chronic higher levels of IL-6 might affect functions of neural regions related to decision making, and thus can modulate rejection of unfair offers. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/23524623/Pro_inflammatory_cytokine_predicts_reduced_rejection_of_unfair_financial_offers_ L2 - https://antibodies.cancer.gov/detail/CPTC-IL6-1 DB - PRIME DP - Unbound Medicine ER -