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Proteomic biomarkers of endometrial cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration.

Abstract

There is a need for research studies into the molecular mechanisms underpinning the link between polycystic ovary syndrome (PCOS) and endometrial cancer (EC) to facilitate screening and to encourage the development of novel strategies to prevent disease progression. The objective of this review was to identify proteomic biomarkers of EC risk in women with PCOS. All eligible published studies on proteomic biomarkers for EC identified through the literature were evaluated. Proteomic biomarkers for EC were then integrated with an updated previously published database of all proteomic biomarkers identified so far in PCOS women. Nine protein biomarkers were similarly either under or over expressed in women with EC and PCOS in various tissues. These include transgelin, pyruvate kinase M1/M2, gelsolin-like capping protein (macrophage capping protein), glutathione S-transferase P, leucine aminopeptidase (cytosol aminopeptidase), peptidyl-prolyl cis-transisomerase, cyclophilin A, complement component C4A and manganese-superoxide dismutase. If validated, these biomarkers may provide a useful framework on which the knowledge base in this area could be developed and will facilitate future mathematical modelling to enhance screening and prevention of EC in women with PCOS who have been shown to be at increased risk.

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  • Authors+Show Affiliations

    ,

    Nottingham Medical School, University of Nottingham, Queen's Medical Centre Campus Nottingham University Hospital, Nottingham, UK. ngalazis@gmail.com

    , , , ,

    Source

    MeSH

    Biomarkers, Tumor
    Carcinoma, Endometrioid
    Databases, Protein
    Endometrial Neoplasms
    Female
    Humans
    Polycystic Ovary Syndrome
    Proteome
    Proteomics
    Risk Factors

    Pub Type(s)

    Journal Article
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    23527552

    Citation

    Galazis, Nicolas, et al. "Proteomic Biomarkers of Endometrial Cancer Risk in Women With Polycystic Ovary Syndrome: a Systematic Review and Biomarker Database Integration." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 29, no. 7, 2013, pp. 638-44.
    Galazis N, Pang YL, Galazi M, et al. Proteomic biomarkers of endometrial cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration. Gynecol Endocrinol. 2013;29(7):638-44.
    Galazis, N., Pang, Y. L., Galazi, M., Haoula, Z., Layfield, R., & Atiomo, W. (2013). Proteomic biomarkers of endometrial cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 29(7), pp. 638-44. doi:10.3109/09513590.2013.777416.
    Galazis N, et al. Proteomic Biomarkers of Endometrial Cancer Risk in Women With Polycystic Ovary Syndrome: a Systematic Review and Biomarker Database Integration. Gynecol Endocrinol. 2013;29(7):638-44. PubMed PMID: 23527552.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Proteomic biomarkers of endometrial cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration. AU - Galazis,Nicolas, AU - Pang,Yik-Lam, AU - Galazi,Myria, AU - Haoula,Zeina, AU - Layfield,Robert, AU - Atiomo,William, Y1 - 2013/03/25/ PY - 2013/3/27/entrez PY - 2013/3/27/pubmed PY - 2014/2/13/medline SP - 638 EP - 44 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 29 IS - 7 N2 - There is a need for research studies into the molecular mechanisms underpinning the link between polycystic ovary syndrome (PCOS) and endometrial cancer (EC) to facilitate screening and to encourage the development of novel strategies to prevent disease progression. The objective of this review was to identify proteomic biomarkers of EC risk in women with PCOS. All eligible published studies on proteomic biomarkers for EC identified through the literature were evaluated. Proteomic biomarkers for EC were then integrated with an updated previously published database of all proteomic biomarkers identified so far in PCOS women. Nine protein biomarkers were similarly either under or over expressed in women with EC and PCOS in various tissues. These include transgelin, pyruvate kinase M1/M2, gelsolin-like capping protein (macrophage capping protein), glutathione S-transferase P, leucine aminopeptidase (cytosol aminopeptidase), peptidyl-prolyl cis-transisomerase, cyclophilin A, complement component C4A and manganese-superoxide dismutase. If validated, these biomarkers may provide a useful framework on which the knowledge base in this area could be developed and will facilitate future mathematical modelling to enhance screening and prevention of EC in women with PCOS who have been shown to be at increased risk. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/23527552/Proteomic_biomarkers_of_endometrial_cancer_risk_in_women_with_polycystic_ovary_syndrome:_a_systematic_review_and_biomarker_database_integration_ L2 - http://www.tandfonline.com/doi/full/10.3109/09513590.2013.777416 DB - PRIME DP - Unbound Medicine ER -