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Role of vitamin D in children with respiratory tract infection.

Abstract

It has recently been shown that vitamin D (VitD) plays an important role in host defences, inflammation and immunity. We reviewed PubMed and selected all of the studies published over the last 15 years concerning VitD deficiency and VitD supplementation in children with respiratory tract infections. Our analysis showed that VitD seems to be very important because of its part in the complexity of the immune system. However, there are few pediatric studies and most have various limitations. First of all, the literature mainly refers to studies concerning the prevalence of VitD insufficiency and deficiency in specific pathologies. Secondly, it is extremely difficult to identify a common specific range of normal, insufficient and deficient VitD levels. Thirdly, the available studies of VitD supplementation often combined VitD with the use of other micronutrients, thus obscuring the role of VitD itself. Finally, different doses have been used for VitD supplementation. These observations clearly highlight the fact that further studies are needed to evaluate the impact of VitD deficiency and insufficiency in terms of the epidemiology and outcomes of pediatric respiratory tract infection, and whether VitD supplementation favours a positive outcome.

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  • Authors

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    Source

    MeSH

    Animals
    Child
    Humans
    Otitis
    Respiratory Tract Infections
    Vitamin D
    Vitamin D Deficiency
    Vitamins

    Pub Type(s)

    Editorial
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    23527704

    Citation

    Esposito, S, et al. "Role of Vitamin D in Children With Respiratory Tract Infection." International Journal of Immunopathology and Pharmacology, vol. 26, no. 1, 2013, pp. 1-13.
    Esposito S, Baggi E, Bianchini S, et al. Role of vitamin D in children with respiratory tract infection. Int J Immunopathol Pharmacol. 2013;26(1):1-13.
    Esposito, S., Baggi, E., Bianchini, S., Marchisio, P., & Principi, N. (2013). Role of vitamin D in children with respiratory tract infection. International Journal of Immunopathology and Pharmacology, 26(1), pp. 1-13.
    Esposito S, et al. Role of Vitamin D in Children With Respiratory Tract Infection. Int J Immunopathol Pharmacol. 2013;26(1):1-13. PubMed PMID: 23527704.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Role of vitamin D in children with respiratory tract infection. AU - Esposito,S, AU - Baggi,E, AU - Bianchini,S, AU - Marchisio,P, AU - Principi,N, PY - 2013/3/27/entrez PY - 2013/3/27/pubmed PY - 2013/9/11/medline SP - 1 EP - 13 JF - International journal of immunopathology and pharmacology JO - Int J Immunopathol Pharmacol VL - 26 IS - 1 N2 - It has recently been shown that vitamin D (VitD) plays an important role in host defences, inflammation and immunity. We reviewed PubMed and selected all of the studies published over the last 15 years concerning VitD deficiency and VitD supplementation in children with respiratory tract infections. Our analysis showed that VitD seems to be very important because of its part in the complexity of the immune system. However, there are few pediatric studies and most have various limitations. First of all, the literature mainly refers to studies concerning the prevalence of VitD insufficiency and deficiency in specific pathologies. Secondly, it is extremely difficult to identify a common specific range of normal, insufficient and deficient VitD levels. Thirdly, the available studies of VitD supplementation often combined VitD with the use of other micronutrients, thus obscuring the role of VitD itself. Finally, different doses have been used for VitD supplementation. These observations clearly highlight the fact that further studies are needed to evaluate the impact of VitD deficiency and insufficiency in terms of the epidemiology and outcomes of pediatric respiratory tract infection, and whether VitD supplementation favours a positive outcome. SN - 0394-6320 UR - https://www.unboundmedicine.com/medline/citation/23527704/full_citation L2 - http://journals.sagepub.com/doi/full/10.1177/039463201302600101?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -