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Urinary excretion of phthalate metabolites, phenols and parabens in rural and urban Danish mother-child pairs.
Int J Hyg Environ Health. 2013 Nov; 216(6):772-83.IJ

Abstract

Some phthalates, parabens and phenols have shown adverse endocrine disrupting effects in animal studies and are also suspected to be involved in human reproductive problems. However, knowledge about exposure sources and biomonitoring data in different subsets of populations are still scarce. Thus, in this study first morning urine samples were collected from 6 to 11 years Danish children and their mothers. The content of seven parabens, nine phenols and metabolites of eight different phthalates were analysed by LC-MS/MS. Two parabens, six phenols and metabolites from six phthalate diesters were measurable in more than 50%, 75% and 90% of the participants, respectively. Thus the children and their mothers were generally exposed simultaneously to a range of phthalates, phenols and parabens. In general, the levels were low but for several of the compounds extreme creatinine adjusted concentrations 100-500-fold higher than the median level were seen in some participants. Children were significantly higher exposed to bisphenol A (BPA) and some of the phthalates (DiBP, DnBP, BBzP, DEHP and DiNP) than their mothers, whereas mothers were higher exposed to compounds related to cosmetics and personal care products such as parabens (MeP, EtP and n-PrP), benzophenone-3, triclosan and diethyl phthalate. However, a very high correlation between mothers and their children was observed for all chemicals. A high individual exposure to one chemical was often associated with a high exposure to other of the chemicals and the possibility of combination effects of multiple simultaneous exposures cannot be excluded.

Authors+Show Affiliations

Department of Growth and Reproduction, Section 5064, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic address: hanne.frederiksen@regionh.dk.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23528233

Citation

Frederiksen, Hanne, et al. "Urinary Excretion of Phthalate Metabolites, Phenols and Parabens in Rural and Urban Danish Mother-child Pairs." International Journal of Hygiene and Environmental Health, vol. 216, no. 6, 2013, pp. 772-83.
Frederiksen H, Nielsen JK, Mørck TA, et al. Urinary excretion of phthalate metabolites, phenols and parabens in rural and urban Danish mother-child pairs. Int J Hyg Environ Health. 2013;216(6):772-83.
Frederiksen, H., Nielsen, J. K., Mørck, T. A., Hansen, P. W., Jensen, J. F., Nielsen, O., Andersson, A. M., & Knudsen, L. E. (2013). Urinary excretion of phthalate metabolites, phenols and parabens in rural and urban Danish mother-child pairs. International Journal of Hygiene and Environmental Health, 216(6), 772-83. https://doi.org/10.1016/j.ijheh.2013.02.006
Frederiksen H, et al. Urinary Excretion of Phthalate Metabolites, Phenols and Parabens in Rural and Urban Danish Mother-child Pairs. Int J Hyg Environ Health. 2013;216(6):772-83. PubMed PMID: 23528233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary excretion of phthalate metabolites, phenols and parabens in rural and urban Danish mother-child pairs. AU - Frederiksen,Hanne, AU - Nielsen,Jeanette Kolstrup Søgaard, AU - Mørck,Thit Aarøe, AU - Hansen,Pernille Winton, AU - Jensen,Janne Fangel, AU - Nielsen,Ole, AU - Andersson,Anna-Maria, AU - Knudsen,Lisbeth E, Y1 - 2013/03/13/ PY - 2012/10/31/received PY - 2013/02/19/revised PY - 2013/02/21/accepted PY - 2013/3/27/entrez PY - 2013/3/27/pubmed PY - 2014/4/9/medline KW - 2,4,5-TCP KW - 2,4,5-trichlorophenol KW - 2,4-DCP KW - 2,4-dichlorophenol KW - 2,5-DCP KW - 2,5-dichlorophenol KW - 2-PP KW - 2-phenylphenol KW - 4-PP KW - 4-phenylphenol KW - BP-3 KW - BPA KW - Benzophenone-3 KW - Bisphenol A KW - BzP KW - Endocrine disruptors KW - EtP KW - Human exposure KW - MBzP KW - MCPP KW - MCiOP KW - MECPP KW - MEHHP KW - MEHP KW - MEOHP KW - MEP KW - MHiNP KW - MOP KW - MOiNP KW - MeP KW - MiBP KW - MiDP KW - MiNP KW - MnBP KW - Risk assessment KW - TCCB KW - TCS KW - Tolerable daily intake KW - Triclosan KW - benzophenone-3 KW - benzylparaben KW - bisphenol A KW - ethylparaben KW - i-BuP KW - i-PrP KW - iso-butylparaben KW - iso-propylparaben KW - methylparaben KW - mono(2-ehthyl-5-carboxypentyl) phthalate KW - mono(2-ehthyl-5-hydroxyhexyl) phthalate KW - mono(2-ehthyl-5-oxohexyl) phthalate KW - mono(2-ehthylhexyl) phthalate KW - mono(3-carboxypropyl) phthalate KW - mono(carboxy-iso-octyl) phthalate KW - mono(hydroxy-iso-nonyl) phthalate KW - mono(oxo-iso-nonyl) phthalate KW - mono-iso-butyl phthalate KW - mono-iso-decyl phthalate KW - mono-iso-nonyl phthalate KW - mono-n-butyl phthalate KW - mono-n-octyl phthalate KW - monobenzyl phthalate KW - monomethyl phthalate KW - n-BuP KW - n-PrP KW - n-butylparaben KW - n-propylparaben KW - triclocarban KW - triclosan SP - 772 EP - 83 JF - International journal of hygiene and environmental health JO - Int J Hyg Environ Health VL - 216 IS - 6 N2 - Some phthalates, parabens and phenols have shown adverse endocrine disrupting effects in animal studies and are also suspected to be involved in human reproductive problems. However, knowledge about exposure sources and biomonitoring data in different subsets of populations are still scarce. Thus, in this study first morning urine samples were collected from 6 to 11 years Danish children and their mothers. The content of seven parabens, nine phenols and metabolites of eight different phthalates were analysed by LC-MS/MS. Two parabens, six phenols and metabolites from six phthalate diesters were measurable in more than 50%, 75% and 90% of the participants, respectively. Thus the children and their mothers were generally exposed simultaneously to a range of phthalates, phenols and parabens. In general, the levels were low but for several of the compounds extreme creatinine adjusted concentrations 100-500-fold higher than the median level were seen in some participants. Children were significantly higher exposed to bisphenol A (BPA) and some of the phthalates (DiBP, DnBP, BBzP, DEHP and DiNP) than their mothers, whereas mothers were higher exposed to compounds related to cosmetics and personal care products such as parabens (MeP, EtP and n-PrP), benzophenone-3, triclosan and diethyl phthalate. However, a very high correlation between mothers and their children was observed for all chemicals. A high individual exposure to one chemical was often associated with a high exposure to other of the chemicals and the possibility of combination effects of multiple simultaneous exposures cannot be excluded. SN - 1618-131X UR - https://www.unboundmedicine.com/medline/citation/23528233/Urinary_excretion_of_phthalate_metabolites_phenols_and_parabens_in_rural_and_urban_Danish_mother_child_pairs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1438-4639(13)00023-0 DB - PRIME DP - Unbound Medicine ER -