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Interaction between dietary factors and Helicobacter pylori infection in noncardia gastric cancer: a population-based case-control study in China.
J Am Coll Nutr. 2012 Oct; 31(5):375-84.JA

Abstract

BACKGROUND

The aim of this study was to investigate the relationships among Helicobacter pylori, dietary factors, and the risk of noncardia gastric cancer in a hospital-based case-control study in China.

METHODS

A case-control study of noncardia gastric cancer was performed at 3 hospitals in Xi'an, China, between September 2008 and July 2010. Participants were 257 men and women with histologically diagnosed primary noncardia gastric cancer and 514 sex- and age-matched (± 5 years) control subjects selected from the communities where the cases were living when diagnosed. A questionnaire was used to obtain information regarding potential risk factors, including diet, and blood samples were obtained to examine H pylori infection status.

RESULTS

Positive H pylori status (odds ratio [OR], 3.2; 95% confidence interval [CI], 0.8-5.9) and high consumption of pickled foods (OR, 27.1; 95%, 8.7-79.1) appeared to increase the risk of noncardia gastric cancer, whereas high consumption of vegetables (OR, 0.3; 95% CI, 0.1-0.89), fruits (OR, 0.2; 95% CI, 0.09-0.81), and soya products (OR, 0.04; 95% CI, 0.01-0.3) appeared to decrease the risk. Consumption of meat, cereals, tubers, eggs, oils, nuts, fish, fresh fruit, and red meat was not clearly associated with risk. Effect modification was observed, such that a relatively high consumption of fruit and vegetables appeared to attenuate the association of H pylori with risk of noncardia gastric cancer (p < 0.05).

CONCLUSIONS

Our data suggest that noncardia gastric cancer is highly preventable through modifications in dietary habits. Given the prevalence of H pylori infection worldwide, information regarding potential interaction between H pylori and lifestyle factors in gastric cancer development, including the dietary factors examined in our study, may prove valuable in future efforts at prevention.

Authors+Show Affiliations

Department of Statistics and Epidemiology, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China. wangxiaoqin@mail.xjtu.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23529995

Citation

Wang, Xiao-Qin, et al. "Interaction Between Dietary Factors and Helicobacter Pylori Infection in Noncardia Gastric Cancer: a Population-based Case-control Study in China." Journal of the American College of Nutrition, vol. 31, no. 5, 2012, pp. 375-84.
Wang XQ, Yan H, Terry PD, et al. Interaction between dietary factors and Helicobacter pylori infection in noncardia gastric cancer: a population-based case-control study in China. J Am Coll Nutr. 2012;31(5):375-84.
Wang, X. Q., Yan, H., Terry, P. D., Wang, J. S., Cheng, L., Wu, W. A., & Hu, S. K. (2012). Interaction between dietary factors and Helicobacter pylori infection in noncardia gastric cancer: a population-based case-control study in China. Journal of the American College of Nutrition, 31(5), 375-84.
Wang XQ, et al. Interaction Between Dietary Factors and Helicobacter Pylori Infection in Noncardia Gastric Cancer: a Population-based Case-control Study in China. J Am Coll Nutr. 2012;31(5):375-84. PubMed PMID: 23529995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between dietary factors and Helicobacter pylori infection in noncardia gastric cancer: a population-based case-control study in China. AU - Wang,Xiao-Qin, AU - Yan,Hong, AU - Terry,Paul D, AU - Wang,Jian-Sheng, AU - Cheng,Li, AU - Wu,Wen-An, AU - Hu,Sen-Ke, PY - 2013/3/27/entrez PY - 2013/3/27/pubmed PY - 2013/10/1/medline SP - 375 EP - 84 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 31 IS - 5 N2 - BACKGROUND: The aim of this study was to investigate the relationships among Helicobacter pylori, dietary factors, and the risk of noncardia gastric cancer in a hospital-based case-control study in China. METHODS: A case-control study of noncardia gastric cancer was performed at 3 hospitals in Xi'an, China, between September 2008 and July 2010. Participants were 257 men and women with histologically diagnosed primary noncardia gastric cancer and 514 sex- and age-matched (± 5 years) control subjects selected from the communities where the cases were living when diagnosed. A questionnaire was used to obtain information regarding potential risk factors, including diet, and blood samples were obtained to examine H pylori infection status. RESULTS: Positive H pylori status (odds ratio [OR], 3.2; 95% confidence interval [CI], 0.8-5.9) and high consumption of pickled foods (OR, 27.1; 95%, 8.7-79.1) appeared to increase the risk of noncardia gastric cancer, whereas high consumption of vegetables (OR, 0.3; 95% CI, 0.1-0.89), fruits (OR, 0.2; 95% CI, 0.09-0.81), and soya products (OR, 0.04; 95% CI, 0.01-0.3) appeared to decrease the risk. Consumption of meat, cereals, tubers, eggs, oils, nuts, fish, fresh fruit, and red meat was not clearly associated with risk. Effect modification was observed, such that a relatively high consumption of fruit and vegetables appeared to attenuate the association of H pylori with risk of noncardia gastric cancer (p < 0.05). CONCLUSIONS: Our data suggest that noncardia gastric cancer is highly preventable through modifications in dietary habits. Given the prevalence of H pylori infection worldwide, information regarding potential interaction between H pylori and lifestyle factors in gastric cancer development, including the dietary factors examined in our study, may prove valuable in future efforts at prevention. SN - 1541-1087 UR - https://www.unboundmedicine.com/medline/citation/23529995/Interaction_between_dietary_factors_and_Helicobacter_pylori_infection_in_noncardia_gastric_cancer:_a_population_based_case_control_study_in_China_ L2 - http://www.tandfonline.com/doi/full/10.1080/07315724.2012.10720447 DB - PRIME DP - Unbound Medicine ER -