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A review of dietary prevention of human papillomavirus-related infection of the cervix and cervical intraepithelial neoplasia.

Abstract

The natural history of cervical cancer suggests that prevention can be achieved by modification of the host's immune system through a nutrient-mediated program. This study reviews the preventive role of dietary intake on cervical intraepithelial neoplasia (CIN) induced by human papillomavirus (HPV). Electronic databases were searched using relevant keywords such as, but not limited to, human papillomavirus infection, cervical intraepithelial neoplasia, lifestyle factors, nutrients intake, and diet. High consumption of fruit and vegetables appears to be protective against CIN. The findings also highlight the possibility of consuming high levels of specific nutrients, vitamins, and minerals, and retaining sufficient level of these elements in the body, especially those with high antioxidants and antiviral properties, to prevent progression of transient and persistent HPV infections to high-grade CIN 2 and 3 (including in situ cervical cancer). The protective effect is not significant for high-risk HPV persistent infections and invasive cervical cancer. Although it appears that intake of specific nutrients, vitamins, and minerals may be good in CIN prevention, there is lack of evidence from controlled trial to confirm this. Health professionals shall focus on implementation of a balanced-diet prevention strategy at an early stage for cervical cancer prevention.

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  • Authors+Show Affiliations

    ,

    School of Public Health, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia. h.chih@curtin.edu.au

    , , ,

    Source

    Nutrition and cancer 65:3 2013 pg 317-28

    MeSH

    Antioxidants
    Antiviral Agents
    Cervical Intraepithelial Neoplasia
    Diet
    Female
    Fruit
    Humans
    MEDLINE
    Minerals
    Papillomavirus Infections
    Risk Factors
    Uterine Cervical Diseases
    Vegetables
    Vitamins

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    23530631

    Citation

    Chih, Hui Jun, et al. "A Review of Dietary Prevention of Human Papillomavirus-related Infection of the Cervix and Cervical Intraepithelial Neoplasia." Nutrition and Cancer, vol. 65, no. 3, 2013, pp. 317-28.
    Chih HJ, Lee AH, Colville L, et al. A review of dietary prevention of human papillomavirus-related infection of the cervix and cervical intraepithelial neoplasia. Nutr Cancer. 2013;65(3):317-28.
    Chih, H. J., Lee, A. H., Colville, L., Binns, C. W., & Xu, D. (2013). A review of dietary prevention of human papillomavirus-related infection of the cervix and cervical intraepithelial neoplasia. Nutrition and Cancer, 65(3), pp. 317-28. doi:10.1080/01635581.2013.757630.
    Chih HJ, et al. A Review of Dietary Prevention of Human Papillomavirus-related Infection of the Cervix and Cervical Intraepithelial Neoplasia. Nutr Cancer. 2013;65(3):317-28. PubMed PMID: 23530631.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A review of dietary prevention of human papillomavirus-related infection of the cervix and cervical intraepithelial neoplasia. AU - Chih,Hui Jun, AU - Lee,Andy H, AU - Colville,Linda, AU - Binns,Colin W, AU - Xu,Daniel, PY - 2013/3/28/entrez PY - 2013/3/28/pubmed PY - 2013/9/17/medline SP - 317 EP - 28 JF - Nutrition and cancer JO - Nutr Cancer VL - 65 IS - 3 N2 - The natural history of cervical cancer suggests that prevention can be achieved by modification of the host's immune system through a nutrient-mediated program. This study reviews the preventive role of dietary intake on cervical intraepithelial neoplasia (CIN) induced by human papillomavirus (HPV). Electronic databases were searched using relevant keywords such as, but not limited to, human papillomavirus infection, cervical intraepithelial neoplasia, lifestyle factors, nutrients intake, and diet. High consumption of fruit and vegetables appears to be protective against CIN. The findings also highlight the possibility of consuming high levels of specific nutrients, vitamins, and minerals, and retaining sufficient level of these elements in the body, especially those with high antioxidants and antiviral properties, to prevent progression of transient and persistent HPV infections to high-grade CIN 2 and 3 (including in situ cervical cancer). The protective effect is not significant for high-risk HPV persistent infections and invasive cervical cancer. Although it appears that intake of specific nutrients, vitamins, and minerals may be good in CIN prevention, there is lack of evidence from controlled trial to confirm this. Health professionals shall focus on implementation of a balanced-diet prevention strategy at an early stage for cervical cancer prevention. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/23530631/full_citation L2 - http://www.tandfonline.com/doi/full/10.1080/01635581.2013.757630 DB - PRIME DP - Unbound Medicine ER -