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High coffee intake, but not caffeine, is associated with reduced estrogen receptor negative and postmenopausal breast cancer risk with no effect modification by CYP1A2 genotype.
Nutr Cancer 2013; 65(3):398-409NC

Abstract

Associations between caffeine and coffee consumption and breast cancer risk are uncertain, with studies suggesting inverse and null associations. Variation in cytochrome P450 1A2 (CYP1A2), a gene responsible for caffeine metabolism, may modify these associations. Cases (n = 3,062) were recruited through the Ontario Cancer Registry and controls (n = 3,427) through random digit dialing. Logistic regression was used to evaluate associations between breast cancer risk and intakes of 7 caffeine-containing items and total caffeine, and examine whether a genetic variant in CYP1A2 (rs762551) modified these associations. Analyses were stratified by estrogen receptor (ER), menopausal, and smoking status. Generally, coffee and caffeine were not associated with breast cancer risk; however, a significant reduction in risk was observed with the highest category of coffee consumption [≥5 cups per day vs. never, multivariate-adjusted odds ratio (MVOR) = 0.71, 95% confidence interval (CI): 0.51, 0.98]. Variant rs762551 did not modify associations. In stratified analyses, high coffee intake was associated with reduced risk of ER- (MVOR = 0.41, 95% CI: 0.19, 0.92) and postmenopausal breast cancer (MVOR = 0.63, 95% CI: 0.43, 0.94). High coffee consumption, but not total caffeine, may be associated with reduced risk of ER- and postmenopausal breast cancers, independent of CYP1A2 genotype. Further studies are needed to replicate these findings.

Authors+Show Affiliations

Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada. beth.lowcock@cancercare.on.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23530639

Citation

Lowcock, Elizabeth C., et al. "High Coffee Intake, but Not Caffeine, Is Associated With Reduced Estrogen Receptor Negative and Postmenopausal Breast Cancer Risk With No Effect Modification By CYP1A2 Genotype." Nutrition and Cancer, vol. 65, no. 3, 2013, pp. 398-409.
Lowcock EC, Cotterchio M, Anderson LN, et al. High coffee intake, but not caffeine, is associated with reduced estrogen receptor negative and postmenopausal breast cancer risk with no effect modification by CYP1A2 genotype. Nutr Cancer. 2013;65(3):398-409.
Lowcock, E. C., Cotterchio, M., Anderson, L. N., Boucher, B. A., & El-Sohemy, A. (2013). High coffee intake, but not caffeine, is associated with reduced estrogen receptor negative and postmenopausal breast cancer risk with no effect modification by CYP1A2 genotype. Nutrition and Cancer, 65(3), pp. 398-409. doi:10.1080/01635581.2013.768348.
Lowcock EC, et al. High Coffee Intake, but Not Caffeine, Is Associated With Reduced Estrogen Receptor Negative and Postmenopausal Breast Cancer Risk With No Effect Modification By CYP1A2 Genotype. Nutr Cancer. 2013;65(3):398-409. PubMed PMID: 23530639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High coffee intake, but not caffeine, is associated with reduced estrogen receptor negative and postmenopausal breast cancer risk with no effect modification by CYP1A2 genotype. AU - Lowcock,Elizabeth C, AU - Cotterchio,Michelle, AU - Anderson,Laura N, AU - Boucher,Beatrice A, AU - El-Sohemy,Ahmed, PY - 2013/3/28/entrez PY - 2013/3/28/pubmed PY - 2013/9/17/medline SP - 398 EP - 409 JF - Nutrition and cancer JO - Nutr Cancer VL - 65 IS - 3 N2 - Associations between caffeine and coffee consumption and breast cancer risk are uncertain, with studies suggesting inverse and null associations. Variation in cytochrome P450 1A2 (CYP1A2), a gene responsible for caffeine metabolism, may modify these associations. Cases (n = 3,062) were recruited through the Ontario Cancer Registry and controls (n = 3,427) through random digit dialing. Logistic regression was used to evaluate associations between breast cancer risk and intakes of 7 caffeine-containing items and total caffeine, and examine whether a genetic variant in CYP1A2 (rs762551) modified these associations. Analyses were stratified by estrogen receptor (ER), menopausal, and smoking status. Generally, coffee and caffeine were not associated with breast cancer risk; however, a significant reduction in risk was observed with the highest category of coffee consumption [≥5 cups per day vs. never, multivariate-adjusted odds ratio (MVOR) = 0.71, 95% confidence interval (CI): 0.51, 0.98]. Variant rs762551 did not modify associations. In stratified analyses, high coffee intake was associated with reduced risk of ER- (MVOR = 0.41, 95% CI: 0.19, 0.92) and postmenopausal breast cancer (MVOR = 0.63, 95% CI: 0.43, 0.94). High coffee consumption, but not total caffeine, may be associated with reduced risk of ER- and postmenopausal breast cancers, independent of CYP1A2 genotype. Further studies are needed to replicate these findings. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/23530639/High_coffee_intake_but_not_caffeine_is_associated_with_reduced_estrogen_receptor_negative_and_postmenopausal_breast_cancer_risk_with_no_effect_modification_by_CYP1A2_genotype_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635581.2013.768348 DB - PRIME DP - Unbound Medicine ER -