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Evaluation of glomerular filtration rate in cats with reduced renal mass and administered meloxicam and acetylsalicylic acid.
Am J Vet Res 2013; 74(4):648-51AJ

Abstract

OBJECTIVE

To determine whether administration of meloxicam or acetylsalicylic acid alters glomerular filtration rate (GFR) in cats with renal azotemia.

ANIMALS

6 young adult cats.

PROCEDURES

3 sexually intact male cats and 3 sexually intact female cats had surgically reduced renal mass and azotemia comparable to International Renal Interest Society chronic kidney disease stages 2 and 3. Renal function was evaluated by measurement of serum creatinine concentration, urinary clearance of exogenously administered creatinine, and the urine protein-to-creatinine concentration ratio (UP:C). Measurements taken in cats receiving placebo at the beginning and end of the study were compared with results obtained at the end of 7 days of treatment with either meloxicam (0.2 mg/kg, SC, on day 1; 0.1 mg/kg, SC, on days 2 to 7) or acetylsalicylic acid (20 mg/kg, PO, on days 1, 4, and 7).

RESULTS

No significant treatment effects on urinary clearance of exogenously administered creatinine, serum creatinine concentration, or UP:C were detected. Mean ± SEM serum creatinine concentration and urinary clearance of exogenously administered creatinine measurements following 7 days of treatment with meloxicam (serum creatinine concentration, 2.67 ± 0.17 mg/dL; urinary clearance of exogenously administered creatinine, 1.34 ± 0.08 mL/min/kg) and acetylsalicylic acid (serum creatinine concentration, 2.62 ± 0.12 mg/dL; urinary clearance of exogenously administered creatinine, 1.35 ± 0.07 mL/min/kg) were not significantly different from the mean baseline values for these variables (serum creatinine concentration, 2.77 ± 0.14 mg/dL; urinary clearance of exogenously administered creatinine, 1.36 ± 0.07 mL/min/kg).

CONCLUSIONS AND CLINICAL RELEVANCE

Neither meloxicam nor acetylsalicylic acid had a measurable effect on urinary clearance of exogenously administered creatinine, serum creatinine concentration, or UP:C. These results are consistent with the hypothesis that GFR of euvolemic cats with normal or reduced renal function is not dependent on cyclooxygenase function.

Authors+Show Affiliations

Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23531076

Citation

Surdyk, Kathryn K., et al. "Evaluation of Glomerular Filtration Rate in Cats With Reduced Renal Mass and Administered Meloxicam and Acetylsalicylic Acid." American Journal of Veterinary Research, vol. 74, no. 4, 2013, pp. 648-51.
Surdyk KK, Brown CA, Brown SA. Evaluation of glomerular filtration rate in cats with reduced renal mass and administered meloxicam and acetylsalicylic acid. Am J Vet Res. 2013;74(4):648-51.
Surdyk, K. K., Brown, C. A., & Brown, S. A. (2013). Evaluation of glomerular filtration rate in cats with reduced renal mass and administered meloxicam and acetylsalicylic acid. American Journal of Veterinary Research, 74(4), pp. 648-51. doi:10.2460/ajvr.74.4.648.
Surdyk KK, Brown CA, Brown SA. Evaluation of Glomerular Filtration Rate in Cats With Reduced Renal Mass and Administered Meloxicam and Acetylsalicylic Acid. Am J Vet Res. 2013;74(4):648-51. PubMed PMID: 23531076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of glomerular filtration rate in cats with reduced renal mass and administered meloxicam and acetylsalicylic acid. AU - Surdyk,Kathryn K, AU - Brown,Cathy A, AU - Brown,Scott A, PY - 2013/3/28/entrez PY - 2013/3/28/pubmed PY - 2013/9/10/medline SP - 648 EP - 51 JF - American journal of veterinary research JO - Am. J. Vet. Res. VL - 74 IS - 4 N2 - OBJECTIVE: To determine whether administration of meloxicam or acetylsalicylic acid alters glomerular filtration rate (GFR) in cats with renal azotemia. ANIMALS: 6 young adult cats. PROCEDURES: 3 sexually intact male cats and 3 sexually intact female cats had surgically reduced renal mass and azotemia comparable to International Renal Interest Society chronic kidney disease stages 2 and 3. Renal function was evaluated by measurement of serum creatinine concentration, urinary clearance of exogenously administered creatinine, and the urine protein-to-creatinine concentration ratio (UP:C). Measurements taken in cats receiving placebo at the beginning and end of the study were compared with results obtained at the end of 7 days of treatment with either meloxicam (0.2 mg/kg, SC, on day 1; 0.1 mg/kg, SC, on days 2 to 7) or acetylsalicylic acid (20 mg/kg, PO, on days 1, 4, and 7). RESULTS: No significant treatment effects on urinary clearance of exogenously administered creatinine, serum creatinine concentration, or UP:C were detected. Mean ± SEM serum creatinine concentration and urinary clearance of exogenously administered creatinine measurements following 7 days of treatment with meloxicam (serum creatinine concentration, 2.67 ± 0.17 mg/dL; urinary clearance of exogenously administered creatinine, 1.34 ± 0.08 mL/min/kg) and acetylsalicylic acid (serum creatinine concentration, 2.62 ± 0.12 mg/dL; urinary clearance of exogenously administered creatinine, 1.35 ± 0.07 mL/min/kg) were not significantly different from the mean baseline values for these variables (serum creatinine concentration, 2.77 ± 0.14 mg/dL; urinary clearance of exogenously administered creatinine, 1.36 ± 0.07 mL/min/kg). CONCLUSIONS AND CLINICAL RELEVANCE: Neither meloxicam nor acetylsalicylic acid had a measurable effect on urinary clearance of exogenously administered creatinine, serum creatinine concentration, or UP:C. These results are consistent with the hypothesis that GFR of euvolemic cats with normal or reduced renal function is not dependent on cyclooxygenase function. SN - 1943-5681 UR - https://www.unboundmedicine.com/medline/citation/23531076/Evaluation_of_glomerular_filtration_rate_in_cats_with_reduced_renal_mass_and_administered_meloxicam_and_acetylsalicylic_acid_ L2 - http://avmajournals.avma.org/doi/full/10.2460/ajvr.74.4.648?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -