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Lipid profile components and incident cerebrovascular events versus coronary heart disease; the result of 9 years follow-up in Tehran Lipid and Glucose Study.
Clin Biochem. 2013 Jun; 46(9):716-21.CB

Abstract

OBJECTIVE

To assess the effects of lipid component total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and non-HDL-C on risk of stroke events versus coronary heart disease (CHD).

METHODS

The study was conducted on 2620 Iranians, aged ≥ 50 years, free from cardiovascular events at baseline (1999-2001). The multivariable hazard ratios (HRs) for stroke/CHD were calculated for 1 mmol/L change in lipid components, using Cox proportional hazard regression.

RESULTS

During 9.1 years of follow-up, 73 and 358 cases of stroke and CHD occurred. We found significant interactions between TC and non-HDL-C with gender in risk prediction of stroke. Among women, multivariate adjusted HRs of ischemic stroke were 1.40 (1.08-1.82), 1.66 (0.71-3.86), 2.27 (0.58-8.91), 1.51 (1.06-2.15) and 1.36 (1.024-1.78) for TC, Ln TG, HDL-C, LDL-C and non-HDL-C respectively, while corresponding HRs of ischemic stroke for men were 0.78 (0.55-1.11), 0.71 (0.33-1.51), 1.04 (0.24-4.47), 0.82 (0.56-1.22), 0.78 (0.55-1.11), respectively. We found no interaction between gender and any of the lipids in risk prediction of incident CHD (p > 0.3). All lipid components were independently associated with CHD in whole population.

CONCLUSION

The associations of lipid components on ischemic stroke were modified by gender. Only among female population, TC, LDL-C and non-HDL-C were independently associated with increased risk of ischemic stroke. Regarding CHD events, all lipid components were significant predictors.

Authors+Show Affiliations

Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23531403

Citation

Tohidi, Maryam, et al. "Lipid Profile Components and Incident Cerebrovascular Events Versus Coronary Heart Disease; the Result of 9 Years Follow-up in Tehran Lipid and Glucose Study." Clinical Biochemistry, vol. 46, no. 9, 2013, pp. 716-21.
Tohidi M, Mohebi R, Cheraghi L, et al. Lipid profile components and incident cerebrovascular events versus coronary heart disease; the result of 9 years follow-up in Tehran Lipid and Glucose Study. Clin Biochem. 2013;46(9):716-21.
Tohidi, M., Mohebi, R., Cheraghi, L., Hajsheikholeslami, F., Aref, S., Nouri, S., Azizi, F., & Hadaegh, F. (2013). Lipid profile components and incident cerebrovascular events versus coronary heart disease; the result of 9 years follow-up in Tehran Lipid and Glucose Study. Clinical Biochemistry, 46(9), 716-21. https://doi.org/10.1016/j.clinbiochem.2013.03.012
Tohidi M, et al. Lipid Profile Components and Incident Cerebrovascular Events Versus Coronary Heart Disease; the Result of 9 Years Follow-up in Tehran Lipid and Glucose Study. Clin Biochem. 2013;46(9):716-21. PubMed PMID: 23531403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid profile components and incident cerebrovascular events versus coronary heart disease; the result of 9 years follow-up in Tehran Lipid and Glucose Study. AU - Tohidi,Maryam, AU - Mohebi,Reza, AU - Cheraghi,Leila, AU - Hajsheikholeslami,Farhad, AU - Aref,Saeed, AU - Nouri,Sara, AU - Azizi,Fereidoun, AU - Hadaegh,Farzad, Y1 - 2013/03/24/ PY - 2012/11/01/received PY - 2013/03/05/revised PY - 2013/03/13/accepted PY - 2013/3/28/entrez PY - 2013/3/28/pubmed PY - 2013/12/16/medline SP - 716 EP - 21 JF - Clinical biochemistry JO - Clin. Biochem. VL - 46 IS - 9 N2 - OBJECTIVE: To assess the effects of lipid component total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and non-HDL-C on risk of stroke events versus coronary heart disease (CHD). METHODS: The study was conducted on 2620 Iranians, aged ≥ 50 years, free from cardiovascular events at baseline (1999-2001). The multivariable hazard ratios (HRs) for stroke/CHD were calculated for 1 mmol/L change in lipid components, using Cox proportional hazard regression. RESULTS: During 9.1 years of follow-up, 73 and 358 cases of stroke and CHD occurred. We found significant interactions between TC and non-HDL-C with gender in risk prediction of stroke. Among women, multivariate adjusted HRs of ischemic stroke were 1.40 (1.08-1.82), 1.66 (0.71-3.86), 2.27 (0.58-8.91), 1.51 (1.06-2.15) and 1.36 (1.024-1.78) for TC, Ln TG, HDL-C, LDL-C and non-HDL-C respectively, while corresponding HRs of ischemic stroke for men were 0.78 (0.55-1.11), 0.71 (0.33-1.51), 1.04 (0.24-4.47), 0.82 (0.56-1.22), 0.78 (0.55-1.11), respectively. We found no interaction between gender and any of the lipids in risk prediction of incident CHD (p > 0.3). All lipid components were independently associated with CHD in whole population. CONCLUSION: The associations of lipid components on ischemic stroke were modified by gender. Only among female population, TC, LDL-C and non-HDL-C were independently associated with increased risk of ischemic stroke. Regarding CHD events, all lipid components were significant predictors. SN - 1873-2933 UR - https://www.unboundmedicine.com/medline/citation/23531403/Lipid_profile_components_and_incident_cerebrovascular_events_versus_coronary_heart_disease L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(13)00105-7 DB - PRIME DP - Unbound Medicine ER -