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Hydrogen sulfide in cell signaling, signal transduction, cellular bioenergetics and physiology in C. elegans.
Gen Physiol Biophys. 2013 Mar; 32(1):1-22.GP

Abstract

Hydrogen sulfide (H2S), long viewed as a toxic gas and environmental hazard, is emerging as a biological mediator with remarkable physiological and pathophysiological relevance. H2S is now viewed as the third main gasotransmitter in the mammalian body. Its pharmacological characteristic possesses similarities to the other two gasotransmitters - nitric oxide (NO) and carbon monoxide (CO). Many of the biological effects of H2S follow a bell-shaped concentration-response; at low concentration or at lower release rates it has beneficial and cytoprotective effects, while at higher concentrations or fast release rates toxicity becomes apparent. Cellular bioenergetics is a prime example for this bell-shaped dose-response, where H2S, at lower concentrations/rates serves as an inorganic substrate and electron donor for mitochondrial ATP generation, while at high concentration it inhibits mitochondrial respiration by blocking the Complex IV in the mitochondrial electron transport chain. The current review is aimed to focus on the following aspects of H2S biology: 1) a general overview of the general pharmacological characteristics of H2S, 2) a summary of the key H2S-mediated signal transduction pathways, 3) an overview of role of H2S in regulation of cellular bioenergetics, 4) key aspects of H2S physiology in C. elegans (a model system) and, finally 5) the therapeutic potential of H2S donating molecules in various disease states.

Authors+Show Affiliations

Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA. katalin.modis@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23531831

Citation

Módis, Katalin, et al. "Hydrogen Sulfide in Cell Signaling, Signal Transduction, Cellular Bioenergetics and Physiology in C. Elegans." General Physiology and Biophysics, vol. 32, no. 1, 2013, pp. 1-22.
Módis K, Wolanska K, Vozdek R. Hydrogen sulfide in cell signaling, signal transduction, cellular bioenergetics and physiology in C. elegans. Gen Physiol Biophys. 2013;32(1):1-22.
Módis, K., Wolanska, K., & Vozdek, R. (2013). Hydrogen sulfide in cell signaling, signal transduction, cellular bioenergetics and physiology in C. elegans. General Physiology and Biophysics, 32(1), 1-22. https://doi.org/10.4149/gpb_2013001
Módis K, Wolanska K, Vozdek R. Hydrogen Sulfide in Cell Signaling, Signal Transduction, Cellular Bioenergetics and Physiology in C. Elegans. Gen Physiol Biophys. 2013;32(1):1-22. PubMed PMID: 23531831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogen sulfide in cell signaling, signal transduction, cellular bioenergetics and physiology in C. elegans. AU - Módis,Katalin, AU - Wolanska,Katarzyna, AU - Vozdek,Roman, PY - 2013/3/28/entrez PY - 2013/3/28/pubmed PY - 2013/6/21/medline SP - 1 EP - 22 JF - General physiology and biophysics JO - Gen Physiol Biophys VL - 32 IS - 1 N2 - Hydrogen sulfide (H2S), long viewed as a toxic gas and environmental hazard, is emerging as a biological mediator with remarkable physiological and pathophysiological relevance. H2S is now viewed as the third main gasotransmitter in the mammalian body. Its pharmacological characteristic possesses similarities to the other two gasotransmitters - nitric oxide (NO) and carbon monoxide (CO). Many of the biological effects of H2S follow a bell-shaped concentration-response; at low concentration or at lower release rates it has beneficial and cytoprotective effects, while at higher concentrations or fast release rates toxicity becomes apparent. Cellular bioenergetics is a prime example for this bell-shaped dose-response, where H2S, at lower concentrations/rates serves as an inorganic substrate and electron donor for mitochondrial ATP generation, while at high concentration it inhibits mitochondrial respiration by blocking the Complex IV in the mitochondrial electron transport chain. The current review is aimed to focus on the following aspects of H2S biology: 1) a general overview of the general pharmacological characteristics of H2S, 2) a summary of the key H2S-mediated signal transduction pathways, 3) an overview of role of H2S in regulation of cellular bioenergetics, 4) key aspects of H2S physiology in C. elegans (a model system) and, finally 5) the therapeutic potential of H2S donating molecules in various disease states. SN - 0231-5882 UR - https://www.unboundmedicine.com/medline/citation/23531831/Hydrogen_sulfide_in_cell_signaling_signal_transduction_cellular_bioenergetics_and_physiology_in_C__elegans_ L2 - http://www.aepress.sk/_downloads/dl.php?from=pubmed&journal=GPB&file=2013_01_1.pdf DB - PRIME DP - Unbound Medicine ER -