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Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: a prospective intervention trial.
Obesity (Silver Spring) 2013; 21(2):284-90O

Abstract

OBJECTIVE

Weight gain is an important risk factor for gastroesophageal reflux disease (GERD); however, whether weight loss can lead to resolution of GERD symptoms is not clear. Our aim was to measure the impact of weight loss on GERD symptoms.

DESIGN AND METHODS

In a prospective cohort study at a tertiary referral center, overweight/obese subjects (BMI 25-39.9 kg/m2) were enrolled in a structured weight loss program. Weight loss strategies included dietary modifications, increased physical activity and behavioral changes. At baseline and at 6 months, BMI and waist circumference were measured and all participants completed a validated reflux disease questionnaire.

RESULTS

A total of 332 adult subjects, mean age 46 years and 66% women were prospectively enrolled. At baseline, the mean body weight, BMI, and waist circumference were 101 (±18) kg, 35 (±5) kg/m2 and 103 (±13) cm. At 6 months, majority of the subjects (97%) lost weight (average weight loss: 13 ± 7.7 kg) and as compared with baseline, there was a significant decrease in the overall prevalence of GERD (15 vs. 37%; P < 0.01) and the mean GERD symptom score (1.8 vs. 5.5; P < 0.01). Overall, 81% of the subjects had reduction in GERD symptom scores; 65% had complete resolution and 15% had partial resolution of reflux symptoms. There was a significant correlation between % body weight loss and reduction in GERD symptom scores (r = 0.17, P < 0.05).

CONCLUSIONS

In conclusion, the overall prevalence of GERD symptoms is high (37%) in overweight and obese subjects. A structured weight loss program can lead to complete resolution of GERD symptoms in the majority of these subjects.

Authors+Show Affiliations

Department of Gastroenterology, Veterans Affairs Medical Center, Kansas City, Missouri, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23532991

Citation

Singh, Mandeep, et al. "Weight Loss Can Lead to Resolution of Gastroesophageal Reflux Disease Symptoms: a Prospective Intervention Trial." Obesity (Silver Spring, Md.), vol. 21, no. 2, 2013, pp. 284-90.
Singh M, Lee J, Gupta N, et al. Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: a prospective intervention trial. Obesity (Silver Spring). 2013;21(2):284-90.
Singh, M., Lee, J., Gupta, N., Gaddam, S., Smith, B. K., Wani, S. B., ... Sharma, P. (2013). Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: a prospective intervention trial. Obesity (Silver Spring, Md.), 21(2), pp. 284-90. doi:10.1002/oby.20279.
Singh M, et al. Weight Loss Can Lead to Resolution of Gastroesophageal Reflux Disease Symptoms: a Prospective Intervention Trial. Obesity (Silver Spring). 2013;21(2):284-90. PubMed PMID: 23532991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: a prospective intervention trial. AU - Singh,Mandeep, AU - Lee,Jaehoon, AU - Gupta,Neil, AU - Gaddam,Srinivas, AU - Smith,Bryan K, AU - Wani,Sachin B, AU - Sullivan,Debra K, AU - Rastogi,Amit, AU - Bansal,Ajay, AU - Donnelly,Joseph E, AU - Sharma,Prateek, PY - 2011/10/10/received PY - 2012/05/30/accepted PY - 2013/3/28/entrez PY - 2013/3/28/pubmed PY - 2013/10/1/medline SP - 284 EP - 90 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 21 IS - 2 N2 - OBJECTIVE: Weight gain is an important risk factor for gastroesophageal reflux disease (GERD); however, whether weight loss can lead to resolution of GERD symptoms is not clear. Our aim was to measure the impact of weight loss on GERD symptoms. DESIGN AND METHODS: In a prospective cohort study at a tertiary referral center, overweight/obese subjects (BMI 25-39.9 kg/m2) were enrolled in a structured weight loss program. Weight loss strategies included dietary modifications, increased physical activity and behavioral changes. At baseline and at 6 months, BMI and waist circumference were measured and all participants completed a validated reflux disease questionnaire. RESULTS: A total of 332 adult subjects, mean age 46 years and 66% women were prospectively enrolled. At baseline, the mean body weight, BMI, and waist circumference were 101 (±18) kg, 35 (±5) kg/m2 and 103 (±13) cm. At 6 months, majority of the subjects (97%) lost weight (average weight loss: 13 ± 7.7 kg) and as compared with baseline, there was a significant decrease in the overall prevalence of GERD (15 vs. 37%; P < 0.01) and the mean GERD symptom score (1.8 vs. 5.5; P < 0.01). Overall, 81% of the subjects had reduction in GERD symptom scores; 65% had complete resolution and 15% had partial resolution of reflux symptoms. There was a significant correlation between % body weight loss and reduction in GERD symptom scores (r = 0.17, P < 0.05). CONCLUSIONS: In conclusion, the overall prevalence of GERD symptoms is high (37%) in overweight and obese subjects. A structured weight loss program can lead to complete resolution of GERD symptoms in the majority of these subjects. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/23532991/Weight_loss_can_lead_to_resolution_of_gastroesophageal_reflux_disease_symptoms:_a_prospective_intervention_trial_ L2 - https://doi.org/10.1002/oby.20279 DB - PRIME DP - Unbound Medicine ER -