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Psychopathology in adolescent offspring of parents with panic disorder, major depression, or both: a 10-year follow-up.
Am J Psychiatry. 2012 Nov; 169(11):1175-84.AJ

Abstract

OBJECTIVE

The authors examined the specificity and course of psychiatric disorders from early childhood through adolescence in offspring of parents with confirmed panic disorder and major depressive disorder.

METHOD

The authors examined rates of psychiatric disorders at 10-year-follow-up (mean age, 14 years) in four groups: offspring of referred parents with panic and depression (N=137), offspring of referred parents with panic without depression (N=26), offspring of referred parents with depression without panic (N=48), and offspring of nonreferred parents with neither disorder (N=80). Follow-up assessments relied on structured interviews with the adolescents and their mothers; diagnoses were rated present if endorsed by either.

RESULTS

Parental panic disorder, independently of parental depression, predicted lifetime rates in offspring of multiple anxiety disorders, panic disorder, agoraphobia, social phobia, and obsessive-compulsive disorder. Parental depression independently predicted offspring bipolar, drug use, and disruptive behavior disorders. Parental panic and depression interacted to predict specific phobia and major depressive disorder. Phobias were elevated in all at-risk groups, and depression was elevated in both offspring groups of parents with depression (with or without panic disorder), with the highest rates in the offspring of parents with depression only. Parental depression independently predicted new onset of depression, parental panic disorder independently predicted new onset of social phobia, and the two interacted to predict new onset of specific phobia and generalized anxiety disorder.

CONCLUSIONS

At-risk offspring continue to develop new disorders as they progress through adolescence. These results support the need to screen and monitor the offspring of adults presenting for treatment of panic disorder or major depressive disorder.

Authors+Show Affiliations

Department of Psychiatry, Massachusetts General Hospital, USA. dhirshfeld@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23534056

Citation

Hirshfeld-Becker, Dina R., et al. "Psychopathology in Adolescent Offspring of Parents With Panic Disorder, Major Depression, or Both: a 10-year Follow-up." The American Journal of Psychiatry, vol. 169, no. 11, 2012, pp. 1175-84.
Hirshfeld-Becker DR, Micco JA, Henin A, et al. Psychopathology in adolescent offspring of parents with panic disorder, major depression, or both: a 10-year follow-up. Am J Psychiatry. 2012;169(11):1175-84.
Hirshfeld-Becker, D. R., Micco, J. A., Henin, A., Petty, C., Faraone, S. V., Mazursky, H., Bruett, L., Rosenbaum, J. F., & Biederman, J. (2012). Psychopathology in adolescent offspring of parents with panic disorder, major depression, or both: a 10-year follow-up. The American Journal of Psychiatry, 169(11), 1175-84.
Hirshfeld-Becker DR, et al. Psychopathology in Adolescent Offspring of Parents With Panic Disorder, Major Depression, or Both: a 10-year Follow-up. Am J Psychiatry. 2012;169(11):1175-84. PubMed PMID: 23534056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychopathology in adolescent offspring of parents with panic disorder, major depression, or both: a 10-year follow-up. AU - Hirshfeld-Becker,Dina R, AU - Micco,Jamie A, AU - Henin,Aude, AU - Petty,Carter, AU - Faraone,Stephen V, AU - Mazursky,Heather, AU - Bruett,Lindsey, AU - Rosenbaum,Jerrold F, AU - Biederman,Joseph, PY - 2013/3/28/entrez PY - 2013/3/28/pubmed PY - 2013/3/28/medline SP - 1175 EP - 84 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 169 IS - 11 N2 - OBJECTIVE: The authors examined the specificity and course of psychiatric disorders from early childhood through adolescence in offspring of parents with confirmed panic disorder and major depressive disorder. METHOD: The authors examined rates of psychiatric disorders at 10-year-follow-up (mean age, 14 years) in four groups: offspring of referred parents with panic and depression (N=137), offspring of referred parents with panic without depression (N=26), offspring of referred parents with depression without panic (N=48), and offspring of nonreferred parents with neither disorder (N=80). Follow-up assessments relied on structured interviews with the adolescents and their mothers; diagnoses were rated present if endorsed by either. RESULTS: Parental panic disorder, independently of parental depression, predicted lifetime rates in offspring of multiple anxiety disorders, panic disorder, agoraphobia, social phobia, and obsessive-compulsive disorder. Parental depression independently predicted offspring bipolar, drug use, and disruptive behavior disorders. Parental panic and depression interacted to predict specific phobia and major depressive disorder. Phobias were elevated in all at-risk groups, and depression was elevated in both offspring groups of parents with depression (with or without panic disorder), with the highest rates in the offspring of parents with depression only. Parental depression independently predicted new onset of depression, parental panic disorder independently predicted new onset of social phobia, and the two interacted to predict new onset of specific phobia and generalized anxiety disorder. CONCLUSIONS: At-risk offspring continue to develop new disorders as they progress through adolescence. These results support the need to screen and monitor the offspring of adults presenting for treatment of panic disorder or major depressive disorder. SN - 1535-7228 UR - https://www.unboundmedicine.com/medline/citation/23534056/Psychopathology_in_adolescent_offspring_of_parents_with_panic_disorder_major_depression_or_both:_a_10_year_follow_up_ L2 - https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2012.11101514?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -