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The effect of homogenization method on the properties of carbamazepine microparticles prepared by spray congealing.
J Microencapsul. 2013; 30(7):692-700.JM

Abstract

Abstract The aim of this study was to investigate the influence of ultrasound and high-shear mixing on the properties of microparticles obtained by spray congealing. Dispersions containing 10% carbamazepine and 90% carrier Gelucire® 50/13 (w/w) were prepared using magnetic stirring, high-shear mixing, or ultrasound. Each preparation was made using hot-melt mixing spray congealing to obtain the microparticles. All microparticles presented a spherical shape with high encapsulation efficiency (>99%). High-shear mixing and ultrasound promoted a decrease in the size of microparticles (D90) to 62.8 ± 4.1 μm and 64.9 ± 3.3 μm, respectively, while magnetic stirring produced microparticles with a size of 84.1 ± 1.4 µm. The use of ultrasound led to microparticles with increased moisture content as identified through sorption isotherm studies. In addition, rheograms showed distinct rheological behaviour among different dispersion preparations. Therefore, the technique used to prepare dispersions for spray congealing can affect specific characteristics of the microparticles and should be controlled during the preparation.

Authors+Show Affiliations

Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Nucleo de Apoio à Pesquisa em Produtos Naturais e Sintéticos, Universidade de São Paulo , Ribeirão Preto, SP , Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23534493

Citation

Martins, Rodrigo Molina, et al. "The Effect of Homogenization Method On the Properties of Carbamazepine Microparticles Prepared By Spray Congealing." Journal of Microencapsulation, vol. 30, no. 7, 2013, pp. 692-700.
Martins RM, Siqueira S, Machado MO, et al. The effect of homogenization method on the properties of carbamazepine microparticles prepared by spray congealing. J Microencapsul. 2013;30(7):692-700.
Martins, R. M., Siqueira, S., Machado, M. O., & Freitas, L. A. (2013). The effect of homogenization method on the properties of carbamazepine microparticles prepared by spray congealing. Journal of Microencapsulation, 30(7), 692-700. https://doi.org/10.3109/02652048.2013.778906
Martins RM, et al. The Effect of Homogenization Method On the Properties of Carbamazepine Microparticles Prepared By Spray Congealing. J Microencapsul. 2013;30(7):692-700. PubMed PMID: 23534493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of homogenization method on the properties of carbamazepine microparticles prepared by spray congealing. AU - Martins,Rodrigo Molina, AU - Siqueira,Silvia, AU - Machado,Marcela Olaia, AU - Freitas,Luis Alexandre Pedro, Y1 - 2013/03/27/ PY - 2013/3/29/entrez PY - 2013/3/29/pubmed PY - 2014/4/22/medline SP - 692 EP - 700 JF - Journal of microencapsulation JO - J Microencapsul VL - 30 IS - 7 N2 - Abstract The aim of this study was to investigate the influence of ultrasound and high-shear mixing on the properties of microparticles obtained by spray congealing. Dispersions containing 10% carbamazepine and 90% carrier Gelucire® 50/13 (w/w) were prepared using magnetic stirring, high-shear mixing, or ultrasound. Each preparation was made using hot-melt mixing spray congealing to obtain the microparticles. All microparticles presented a spherical shape with high encapsulation efficiency (>99%). High-shear mixing and ultrasound promoted a decrease in the size of microparticles (D90) to 62.8 ± 4.1 μm and 64.9 ± 3.3 μm, respectively, while magnetic stirring produced microparticles with a size of 84.1 ± 1.4 µm. The use of ultrasound led to microparticles with increased moisture content as identified through sorption isotherm studies. In addition, rheograms showed distinct rheological behaviour among different dispersion preparations. Therefore, the technique used to prepare dispersions for spray congealing can affect specific characteristics of the microparticles and should be controlled during the preparation. SN - 1464-5246 UR - https://www.unboundmedicine.com/medline/citation/23534493/The_effect_of_homogenization_method_on_the_properties_of_carbamazepine_microparticles_prepared_by_spray_congealing_ L2 - https://www.tandfonline.com/doi/full/10.3109/02652048.2013.778906 DB - PRIME DP - Unbound Medicine ER -