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Dietary calcium from dairy and nondairy sources, and risk of symptomatic kidney stones.
J Urol 2013; 190(4):1255-9JU

Abstract

PURPOSE

Because of high correlations between dairy intake and total dietary calcium, previously reported associations between lower calcium intake and increased kidney stone risk represent de facto associations between milk products and risk. We examined associations between dietary calcium from nondairy and dairy sources, and symptomatic nephrolithiasis.

MATERIALS AND METHODS

We performed prospective studies in the Health Professionals Follow-up Study (HPFS) in 30,762 men, and in the Nurses' Health Study (NHS) I and II in 94,164 and 101,701 women, respectively. We excluded men 60 years old or older because we previously reported inverse associations between calcium intake and risk only in men younger than 60 years. Food frequency questionnaires were used to assess calcium intake every 4 years. We used Cox proportional hazards regression to adjust for age, body mass index, supplemental calcium, diet and other factors.

RESULTS

We documented 5,270 incident kidney stones during the combined 56 years of followup. In participants in the highest vs the lowest quintile of nondairy dietary calcium the multivariate relative risk of kidney stones was 0.71 (95% CI 0.56-0.92, p for trend 0.007) in HPFS, 0.82 (95% CI 0.69-0.98, p trend 0.08) in NHS I and 0.74 (95% CI 0.63-0.87, p trend 0.002) in NHS II. When comparing the highest to the lowest quintile of dairy calcium, the multivariate relative risk was 0.77 (95% CI 0.63-0.95, p trend 0.01) for HPFS, 0.83 (95% CI 0.69-0.99, p trend 0.05) for NHS I and 0.76 (95% CI 0.65-0.88, p trend 0.001) for NHS II.

CONCLUSIONS

Higher dietary calcium from nondairy or dairy sources is independently associated with a lower kidney stone risk.

Authors+Show Affiliations

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Division of Nephrology and Transplantation, Maine Medical Center, Portland, Maine. Electronic address: entaylor@partners.org.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23535174

Citation

Taylor, Eric N., and Gary C. Curhan. "Dietary Calcium From Dairy and Nondairy Sources, and Risk of Symptomatic Kidney Stones." The Journal of Urology, vol. 190, no. 4, 2013, pp. 1255-9.
Taylor EN, Curhan GC. Dietary calcium from dairy and nondairy sources, and risk of symptomatic kidney stones. J Urol. 2013;190(4):1255-9.
Taylor, E. N., & Curhan, G. C. (2013). Dietary calcium from dairy and nondairy sources, and risk of symptomatic kidney stones. The Journal of Urology, 190(4), pp. 1255-9. doi:10.1016/j.juro.2013.03.074.
Taylor EN, Curhan GC. Dietary Calcium From Dairy and Nondairy Sources, and Risk of Symptomatic Kidney Stones. J Urol. 2013;190(4):1255-9. PubMed PMID: 23535174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary calcium from dairy and nondairy sources, and risk of symptomatic kidney stones. AU - Taylor,Eric N, AU - Curhan,Gary C, Y1 - 2013/03/25/ PY - 2013/03/18/accepted PY - 2013/3/29/entrez PY - 2013/3/29/pubmed PY - 2013/12/16/medline KW - BMI KW - FFQ KW - body mass index KW - calcium KW - diet KW - food-frequency questionnaire KW - kidney KW - kidney calculi KW - risk SP - 1255 EP - 9 JF - The Journal of urology JO - J. Urol. VL - 190 IS - 4 N2 - PURPOSE: Because of high correlations between dairy intake and total dietary calcium, previously reported associations between lower calcium intake and increased kidney stone risk represent de facto associations between milk products and risk. We examined associations between dietary calcium from nondairy and dairy sources, and symptomatic nephrolithiasis. MATERIALS AND METHODS: We performed prospective studies in the Health Professionals Follow-up Study (HPFS) in 30,762 men, and in the Nurses' Health Study (NHS) I and II in 94,164 and 101,701 women, respectively. We excluded men 60 years old or older because we previously reported inverse associations between calcium intake and risk only in men younger than 60 years. Food frequency questionnaires were used to assess calcium intake every 4 years. We used Cox proportional hazards regression to adjust for age, body mass index, supplemental calcium, diet and other factors. RESULTS: We documented 5,270 incident kidney stones during the combined 56 years of followup. In participants in the highest vs the lowest quintile of nondairy dietary calcium the multivariate relative risk of kidney stones was 0.71 (95% CI 0.56-0.92, p for trend 0.007) in HPFS, 0.82 (95% CI 0.69-0.98, p trend 0.08) in NHS I and 0.74 (95% CI 0.63-0.87, p trend 0.002) in NHS II. When comparing the highest to the lowest quintile of dairy calcium, the multivariate relative risk was 0.77 (95% CI 0.63-0.95, p trend 0.01) for HPFS, 0.83 (95% CI 0.69-0.99, p trend 0.05) for NHS I and 0.76 (95% CI 0.65-0.88, p trend 0.001) for NHS II. CONCLUSIONS: Higher dietary calcium from nondairy or dairy sources is independently associated with a lower kidney stone risk. SN - 1527-3792 UR - https://www.unboundmedicine.com/medline/citation/23535174/Dietary_calcium_from_dairy_and_nondairy_sources_and_risk_of_symptomatic_kidney_stones_ L2 - https://www.jurology.com/doi/full/10.1016/j.juro.2013.03.074?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -