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Consumption of fruit, vegetables, and other food groups and the risk of nasopharyngeal carcinoma.
Cancer Causes Control. 2013 Jun; 24(6):1157-65.CC

Abstract

PURPOSE

The role of dietary habits in the etiology of nasopharyngeal carcinoma (NPC) has been extensively investigated in high-incidence areas, but evidence is scanty in low-incidence populations. This study aimed to investigate the relationship between NPC risk and a wide range of food groups in the Italian population.

METHODS

We conducted a hospital-based case-control study in Italy on 198, histologically confirmed, NPC cases of Caucasian ethnicity, aged 18-76 years. Controls were 594 Caucasian cancer-free patients admitted to general hospitals for acute conditions. Odds ratios (ORs) and the corresponding confidence intervals (CIs) were estimated through logistic regression, adjusting for socio-demographic characteristics, tobacco smoking, alcohol drinking, and energy intake.

RESULTS

Elevated vegetable consumption was inversely related to NPC risk (OR for highest vs. lower quartile = 0.51; 95 % CI 0.29-0.90). The association was particularly strong for yellow- or red-pigmented vegetables (OR = 0.31; 95 % CI 0.18-0.54), and this effect was stronger among never smokers (OR = 0.18; 95 % CI 0.06-0.55) than among ever smokers (OR = 0.37; 95 % CI 0.19-0.71). Increased NPC risk emerged for elevated eggs consumption (OR = 2.50; 95 % CI 1.44-4.32; p-trend <0.01). No significant associations emerged between NPC risk and consumption of cereals, meat, fish, dairy products, and sweets.

CONCLUSIONS

The study findings show that, also in low-risk populations, vegetable consumption is a protective factor against NPC. The stronger effect for yellow- or red-pigmented vegetables is in agreement with the inverse association reported for carotenoids intake.

Authors+Show Affiliations

Unit of Epidemiology and Biostatistics, Centro di Riferimento OncologicoI, IRCCS, Via Franco Gallini, 2, 33081, Aviano, PN, Italy. polesel@cro.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23535867

Citation

Polesel, Jerry, et al. "Consumption of Fruit, Vegetables, and Other Food Groups and the Risk of Nasopharyngeal Carcinoma." Cancer Causes & Control : CCC, vol. 24, no. 6, 2013, pp. 1157-65.
Polesel J, Serraino D, Negri E, et al. Consumption of fruit, vegetables, and other food groups and the risk of nasopharyngeal carcinoma. Cancer Causes Control. 2013;24(6):1157-65.
Polesel, J., Serraino, D., Negri, E., Barzan, L., Vaccher, E., Montella, M., Zucchetto, A., Garavello, W., Franceschi, S., La Vecchia, C., & Talamini, R. (2013). Consumption of fruit, vegetables, and other food groups and the risk of nasopharyngeal carcinoma. Cancer Causes & Control : CCC, 24(6), 1157-65. https://doi.org/10.1007/s10552-013-0195-z
Polesel J, et al. Consumption of Fruit, Vegetables, and Other Food Groups and the Risk of Nasopharyngeal Carcinoma. Cancer Causes Control. 2013;24(6):1157-65. PubMed PMID: 23535867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of fruit, vegetables, and other food groups and the risk of nasopharyngeal carcinoma. AU - Polesel,Jerry, AU - Serraino,Diego, AU - Negri,Eva, AU - Barzan,Luigi, AU - Vaccher,Emanuela, AU - Montella,Maurizio, AU - Zucchetto,Antonella, AU - Garavello,Werner, AU - Franceschi,Silvia, AU - La Vecchia,Carlo, AU - Talamini,Renato, Y1 - 2013/03/28/ PY - 2012/10/11/received PY - 2013/03/20/accepted PY - 2013/3/29/entrez PY - 2013/3/29/pubmed PY - 2014/5/6/medline SP - 1157 EP - 65 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 24 IS - 6 N2 - PURPOSE: The role of dietary habits in the etiology of nasopharyngeal carcinoma (NPC) has been extensively investigated in high-incidence areas, but evidence is scanty in low-incidence populations. This study aimed to investigate the relationship between NPC risk and a wide range of food groups in the Italian population. METHODS: We conducted a hospital-based case-control study in Italy on 198, histologically confirmed, NPC cases of Caucasian ethnicity, aged 18-76 years. Controls were 594 Caucasian cancer-free patients admitted to general hospitals for acute conditions. Odds ratios (ORs) and the corresponding confidence intervals (CIs) were estimated through logistic regression, adjusting for socio-demographic characteristics, tobacco smoking, alcohol drinking, and energy intake. RESULTS: Elevated vegetable consumption was inversely related to NPC risk (OR for highest vs. lower quartile = 0.51; 95 % CI 0.29-0.90). The association was particularly strong for yellow- or red-pigmented vegetables (OR = 0.31; 95 % CI 0.18-0.54), and this effect was stronger among never smokers (OR = 0.18; 95 % CI 0.06-0.55) than among ever smokers (OR = 0.37; 95 % CI 0.19-0.71). Increased NPC risk emerged for elevated eggs consumption (OR = 2.50; 95 % CI 1.44-4.32; p-trend <0.01). No significant associations emerged between NPC risk and consumption of cereals, meat, fish, dairy products, and sweets. CONCLUSIONS: The study findings show that, also in low-risk populations, vegetable consumption is a protective factor against NPC. The stronger effect for yellow- or red-pigmented vegetables is in agreement with the inverse association reported for carotenoids intake. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/23535867/Consumption_of_fruit_vegetables_and_other_food_groups_and_the_risk_of_nasopharyngeal_carcinoma_ L2 - https://doi.org/10.1007/s10552-013-0195-z DB - PRIME DP - Unbound Medicine ER -