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Effect of diets differing in glycemic index and glycemic load on cardiovascular risk factors: review of randomized controlled-feeding trials.
Nutrients. 2013 Mar 28; 5(4):1071-80.N

Abstract

Despite a considerable amount of data available on the relationship between dietary glycemic index (GI) or load (GL) and cardiovascular disease (CVD) risk factors, in aggregate, the area remains unsettled. The aim of the present review was to summarize the effect of diets differing in GI/GL on CVD risk factors, by examining randomized controlled-feeding trials that provided all food and beverages to adult participants. The studies included a low and high GI/GL diet phase for a minimum of four weeks duration, and reported at least one outcome related to CVD risk; glucose homeostasis, lipid profile or inflammatory status. Ten publications representing five trials were identified. The low GI/GL compared to the high GI/GL diet unexpectedly resulted in significantly higher fasting glucose concentrations in two of the trials, and a lower area under the curve for glucose and insulin in one of the two studies during an oral glucose tolerance test. Response of plasma total, low density lipoprotein and high density lipoprotein cholesterol concentrations was conflicting in two of the studies for which data were available. There was either weak or no effect on inflammatory markers. The results of the five randomized controlled trials satisfying the inclusion criteria suggest inconsistent effects of the GI/GL value of the diet on CVD risk factors.

Authors+Show Affiliations

Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23538939

Citation

Kristo, Aleksandra S., et al. "Effect of Diets Differing in Glycemic Index and Glycemic Load On Cardiovascular Risk Factors: Review of Randomized Controlled-feeding Trials." Nutrients, vol. 5, no. 4, 2013, pp. 1071-80.
Kristo AS, Matthan NR, Lichtenstein AH. Effect of diets differing in glycemic index and glycemic load on cardiovascular risk factors: review of randomized controlled-feeding trials. Nutrients. 2013;5(4):1071-80.
Kristo, A. S., Matthan, N. R., & Lichtenstein, A. H. (2013). Effect of diets differing in glycemic index and glycemic load on cardiovascular risk factors: review of randomized controlled-feeding trials. Nutrients, 5(4), 1071-80. https://doi.org/10.3390/nu5041071
Kristo AS, Matthan NR, Lichtenstein AH. Effect of Diets Differing in Glycemic Index and Glycemic Load On Cardiovascular Risk Factors: Review of Randomized Controlled-feeding Trials. Nutrients. 2013 Mar 28;5(4):1071-80. PubMed PMID: 23538939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of diets differing in glycemic index and glycemic load on cardiovascular risk factors: review of randomized controlled-feeding trials. AU - Kristo,Aleksandra S, AU - Matthan,Nirupa R, AU - Lichtenstein,Alice H, Y1 - 2013/03/28/ PY - 2013/02/06/received PY - 2013/02/26/revised PY - 2013/03/12/accepted PY - 2013/3/30/entrez PY - 2013/3/30/pubmed PY - 2013/7/17/medline SP - 1071 EP - 80 JF - Nutrients JO - Nutrients VL - 5 IS - 4 N2 - Despite a considerable amount of data available on the relationship between dietary glycemic index (GI) or load (GL) and cardiovascular disease (CVD) risk factors, in aggregate, the area remains unsettled. The aim of the present review was to summarize the effect of diets differing in GI/GL on CVD risk factors, by examining randomized controlled-feeding trials that provided all food and beverages to adult participants. The studies included a low and high GI/GL diet phase for a minimum of four weeks duration, and reported at least one outcome related to CVD risk; glucose homeostasis, lipid profile or inflammatory status. Ten publications representing five trials were identified. The low GI/GL compared to the high GI/GL diet unexpectedly resulted in significantly higher fasting glucose concentrations in two of the trials, and a lower area under the curve for glucose and insulin in one of the two studies during an oral glucose tolerance test. Response of plasma total, low density lipoprotein and high density lipoprotein cholesterol concentrations was conflicting in two of the studies for which data were available. There was either weak or no effect on inflammatory markers. The results of the five randomized controlled trials satisfying the inclusion criteria suggest inconsistent effects of the GI/GL value of the diet on CVD risk factors. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/23538939/Effect_of_diets_differing_in_glycemic_index_and_glycemic_load_on_cardiovascular_risk_factors:_review_of_randomized_controlled_feeding_trials_ L2 - http://www.mdpi.com/resolver?pii=nu5041071 DB - PRIME DP - Unbound Medicine ER -