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Skin pentosidine in very early hip/knee osteoarthritis (CHECK) is not a strong independent predictor of radiographic progression over 5 years follow-up.
Osteoarthritis Cartilage 2013; 21(6):823-30OC

Abstract

OBJECTIVES

Age-related changes in articular cartilage are likely to play a role in the etiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced glycation end products (AGEs). The present study evaluates whether pentosidine can predict radiographic progression and/or burden over 5 years follow-up in a cohort of early knee and/or hip OA.

DESIGN

The 5 years follow-up data of 300 patients from cohort hip & cohort knee (CHECK) were used. Radiographic progression and burden were assessed by X-rays of both knees and hips (Kellgren and Lawrence (K&L) and Altman scores). Baseline pentosidine levels (and urinary CTXII as a comparator) were measured by high-performance-liquid-chromatography (HPLC) and enzyme linked immunosorbent assay (ELISA). Univariable and multivariable associations including baseline radiographic damage, age, gender, body mass index (BMI) and kidney function were performed.

RESULTS

Both pentosidine and urinary C-terminal telopeptide of type II collagen (uCTXII) correlated with radiographic progression and burden. In general pentosidine did not have an added predictive value to uCTXII for progression nor burden of the disease. The best prediction was obtained for burden of radiographic damage (R(2) = 0.60-0.88), bus this was predominantly determined by baseline radiographic damage (without this parameter R(2) = 0.07-0.17). Interestingly, pentosidine significantly added to prediction of osteophyte formation, whereas uCTXII significantly added to prediction of JSN in multivariable analysis.

CONCLUSION

Pentosidine adds to prediction of radiographic progression and burden of osteophyte formation and uCTXII to radiographic progression and burden of JSN, but overall skin pentosidine did not perform better that uCTXII in predicting radiographic progression or burden. Burden of damage over 5 years is mainly determined by radiographic joint damage at baseline.

Authors+Show Affiliations

Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23541875

Citation

Vos, P A J M., et al. "Skin Pentosidine in Very Early Hip/knee Osteoarthritis (CHECK) Is Not a Strong Independent Predictor of Radiographic Progression Over 5 Years Follow-up." Osteoarthritis and Cartilage, vol. 21, no. 6, 2013, pp. 823-30.
Vos PA, Welsing PM, deGroot J, et al. Skin pentosidine in very early hip/knee osteoarthritis (CHECK) is not a strong independent predictor of radiographic progression over 5 years follow-up. Osteoarthr Cartil. 2013;21(6):823-30.
Vos, P. A., Welsing, P. M., deGroot, J., Huisman, A. M., Oostveen, J. C., Reijman, M., ... Lafeber, F. P. (2013). Skin pentosidine in very early hip/knee osteoarthritis (CHECK) is not a strong independent predictor of radiographic progression over 5 years follow-up. Osteoarthritis and Cartilage, 21(6), pp. 823-30. doi:10.1016/j.joca.2013.03.006.
Vos PA, et al. Skin Pentosidine in Very Early Hip/knee Osteoarthritis (CHECK) Is Not a Strong Independent Predictor of Radiographic Progression Over 5 Years Follow-up. Osteoarthr Cartil. 2013;21(6):823-30. PubMed PMID: 23541875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skin pentosidine in very early hip/knee osteoarthritis (CHECK) is not a strong independent predictor of radiographic progression over 5 years follow-up. AU - Vos,P A J M, AU - Welsing,P M J, AU - deGroot,J, AU - Huisman,A M, AU - Oostveen,J C M, AU - Reijman,M, AU - Damen,J, AU - Mastbergen,S C, AU - Lafeber,F P J G, Y1 - 2013/03/27/ PY - 2012/08/26/received PY - 2013/03/03/revised PY - 2013/03/08/accepted PY - 2013/4/2/entrez PY - 2013/4/2/pubmed PY - 2013/12/16/medline SP - 823 EP - 30 JF - Osteoarthritis and cartilage JO - Osteoarthr. Cartil. VL - 21 IS - 6 N2 - OBJECTIVES: Age-related changes in articular cartilage are likely to play a role in the etiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced glycation end products (AGEs). The present study evaluates whether pentosidine can predict radiographic progression and/or burden over 5 years follow-up in a cohort of early knee and/or hip OA. DESIGN: The 5 years follow-up data of 300 patients from cohort hip & cohort knee (CHECK) were used. Radiographic progression and burden were assessed by X-rays of both knees and hips (Kellgren and Lawrence (K&L) and Altman scores). Baseline pentosidine levels (and urinary CTXII as a comparator) were measured by high-performance-liquid-chromatography (HPLC) and enzyme linked immunosorbent assay (ELISA). Univariable and multivariable associations including baseline radiographic damage, age, gender, body mass index (BMI) and kidney function were performed. RESULTS: Both pentosidine and urinary C-terminal telopeptide of type II collagen (uCTXII) correlated with radiographic progression and burden. In general pentosidine did not have an added predictive value to uCTXII for progression nor burden of the disease. The best prediction was obtained for burden of radiographic damage (R(2) = 0.60-0.88), bus this was predominantly determined by baseline radiographic damage (without this parameter R(2) = 0.07-0.17). Interestingly, pentosidine significantly added to prediction of osteophyte formation, whereas uCTXII significantly added to prediction of JSN in multivariable analysis. CONCLUSION: Pentosidine adds to prediction of radiographic progression and burden of osteophyte formation and uCTXII to radiographic progression and burden of JSN, but overall skin pentosidine did not perform better that uCTXII in predicting radiographic progression or burden. Burden of damage over 5 years is mainly determined by radiographic joint damage at baseline. SN - 1522-9653 UR - https://www.unboundmedicine.com/medline/citation/23541875/Skin_pentosidine_in_very_early_hip/knee_osteoarthritis__CHECK__is_not_a_strong_independent_predictor_of_radiographic_progression_over_5_years_follow_up_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1063-4584(13)00731-0 DB - PRIME DP - Unbound Medicine ER -