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Anti-inflammatory and antioxidant properties of hydroalcoholic crude extract from Casearia sylvestris Sw. (Salicaceae).
J Ethnopharmacol. 2013 Jun 03; 147(3):612-7.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Casearia sylvestris Sw. is widely used in popular medicine to treat inflammatory conditions.

AIM OF THE STUDY

To investigate the anti-inflammatory and antioxidant properties of hydroalcoholic crude extract (HCE) taken from Casearia sylvestris Sw. (Salicaceae).

METHODS AND RESULTS

The effect of the HCE from this plant (3-300 mg/kg) on the reduction of inflammatory response to carrageenan was investigated in pleurisy in rats (intrapleural, 2% in 0.2 mL) or paw edema in mice (intraplantar, 300 μg/20 μL, right hind paw). The plant anti-inflammatory action was assessed by its capability in inhibiting cell migration, enzymatic activity of myeloperoxidase (MPO) and production of nitrite/nitrate or edema. The in vitro antioxidant activity of this extract against lipid peroxidation and damage to proteins was assessed as possible pathways to contribute as anti-inflammatory mechanisms. Carrageenan-induced hind paw edema (739.3 ± 11.9 μm) was reduced by HCE (30 mg/kg: 462.8 ± 28.38 μm) to similar extents as dexametasone (365.1 ± 16.7). In pleurisy, treatment of the animals with HCE (100mg/kg: 0.010 ± 0.001 mU/mg of protein) also reduced MPO activity augmented by carrageenan (0.020 ± 0.001 mU/mg of protein) as well as leukocytes migration (carrageenan: 17.8890 ± 2.3900 leukocytes/mL, HCE 100mg/kg: 7.0880 ± 9631 leukocytes/mL). Significant effects were also observed in animals treated with different doses of HCE in biochemical tests for oxidative stress analysis.

CONCLUSION

The anti-inflammatory and antioxidant effects of HCE from Casearia sylvestris Sw. suggests a potential therapeutic benefit of this plant in treatment of inflammatory conditions.

Authors+Show Affiliations

Curso de Farmácia, Av. José Acácio Moreira, 787, Bairro DEHON, 84, 700-900 Tubarão, SC, Brazil. micheline.albano@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23542040

Citation

Albano, Micheline N., et al. "Anti-inflammatory and Antioxidant Properties of Hydroalcoholic Crude Extract From Casearia Sylvestris Sw. (Salicaceae)." Journal of Ethnopharmacology, vol. 147, no. 3, 2013, pp. 612-7.
Albano MN, da Silveira MR, Danielski LG, et al. Anti-inflammatory and antioxidant properties of hydroalcoholic crude extract from Casearia sylvestris Sw. (Salicaceae). J Ethnopharmacol. 2013;147(3):612-7.
Albano, M. N., da Silveira, M. R., Danielski, L. G., Florentino, D., Petronilho, F., & Piovezan, A. P. (2013). Anti-inflammatory and antioxidant properties of hydroalcoholic crude extract from Casearia sylvestris Sw. (Salicaceae). Journal of Ethnopharmacology, 147(3), 612-7. https://doi.org/10.1016/j.jep.2013.03.049
Albano MN, et al. Anti-inflammatory and Antioxidant Properties of Hydroalcoholic Crude Extract From Casearia Sylvestris Sw. (Salicaceae). J Ethnopharmacol. 2013 Jun 3;147(3):612-7. PubMed PMID: 23542040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and antioxidant properties of hydroalcoholic crude extract from Casearia sylvestris Sw. (Salicaceae). AU - Albano,Micheline N, AU - da Silveira,Márcia R, AU - Danielski,Lucineia G, AU - Florentino,Drielly, AU - Petronilho,Fabrícia, AU - Piovezan,Anna P, Y1 - 2013/03/29/ PY - 2013/02/28/received PY - 2013/03/17/revised PY - 2013/03/18/accepted PY - 2013/4/2/entrez PY - 2013/4/2/pubmed PY - 2013/10/23/medline SP - 612 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 147 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Casearia sylvestris Sw. is widely used in popular medicine to treat inflammatory conditions. AIM OF THE STUDY: To investigate the anti-inflammatory and antioxidant properties of hydroalcoholic crude extract (HCE) taken from Casearia sylvestris Sw. (Salicaceae). METHODS AND RESULTS: The effect of the HCE from this plant (3-300 mg/kg) on the reduction of inflammatory response to carrageenan was investigated in pleurisy in rats (intrapleural, 2% in 0.2 mL) or paw edema in mice (intraplantar, 300 μg/20 μL, right hind paw). The plant anti-inflammatory action was assessed by its capability in inhibiting cell migration, enzymatic activity of myeloperoxidase (MPO) and production of nitrite/nitrate or edema. The in vitro antioxidant activity of this extract against lipid peroxidation and damage to proteins was assessed as possible pathways to contribute as anti-inflammatory mechanisms. Carrageenan-induced hind paw edema (739.3 ± 11.9 μm) was reduced by HCE (30 mg/kg: 462.8 ± 28.38 μm) to similar extents as dexametasone (365.1 ± 16.7). In pleurisy, treatment of the animals with HCE (100mg/kg: 0.010 ± 0.001 mU/mg of protein) also reduced MPO activity augmented by carrageenan (0.020 ± 0.001 mU/mg of protein) as well as leukocytes migration (carrageenan: 17.8890 ± 2.3900 leukocytes/mL, HCE 100mg/kg: 7.0880 ± 9631 leukocytes/mL). Significant effects were also observed in animals treated with different doses of HCE in biochemical tests for oxidative stress analysis. CONCLUSION: The anti-inflammatory and antioxidant effects of HCE from Casearia sylvestris Sw. suggests a potential therapeutic benefit of this plant in treatment of inflammatory conditions. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/23542040/Anti_inflammatory_and_antioxidant_properties_of_hydroalcoholic_crude_extract_from_Casearia_sylvestris_Sw___Salicaceae__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(13)00205-5 DB - PRIME DP - Unbound Medicine ER -