Citation
Kort, A, et al. "Quantification of Cabazitaxel, Its Metabolite Docetaxel and the Determination of the Demethylated Metabolites RPR112698 and RPR123142 as Docetaxel Equivalents in Human Plasma By Liquid Chromatography-tandem Mass Spectrometry." Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, vol. 925, 2013, pp. 117-23.
Kort A, Hillebrand MJ, Cirkel GA, et al. Quantification of cabazitaxel, its metabolite docetaxel and the determination of the demethylated metabolites RPR112698 and RPR123142 as docetaxel equivalents in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2013;925:117-23.
Kort, A., Hillebrand, M. J., Cirkel, G. A., Voest, E. E., Schinkel, A. H., Rosing, H., Schellens, J. H., & Beijnen, J. H. (2013). Quantification of cabazitaxel, its metabolite docetaxel and the determination of the demethylated metabolites RPR112698 and RPR123142 as docetaxel equivalents in human plasma by liquid chromatography-tandem mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 925, 117-23. https://doi.org/10.1016/j.jchromb.2013.02.034
Kort A, et al. Quantification of Cabazitaxel, Its Metabolite Docetaxel and the Determination of the Demethylated Metabolites RPR112698 and RPR123142 as Docetaxel Equivalents in Human Plasma By Liquid Chromatography-tandem Mass Spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Apr 15;925:117-23. PubMed PMID: 23542607.
TY - JOUR
T1 - Quantification of cabazitaxel, its metabolite docetaxel and the determination of the demethylated metabolites RPR112698 and RPR123142 as docetaxel equivalents in human plasma by liquid chromatography-tandem mass spectrometry.
AU - Kort,A,
AU - Hillebrand,M J X,
AU - Cirkel,G A,
AU - Voest,E E,
AU - Schinkel,A H,
AU - Rosing,H,
AU - Schellens,J H M,
AU - Beijnen,J H,
Y1 - 2013/03/05/
PY - 2012/10/17/received
PY - 2013/02/11/revised
PY - 2013/02/19/accepted
PY - 2013/4/2/entrez
PY - 2013/4/2/pubmed
PY - 2013/7/17/medline
SP - 117
EP - 23
JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
JO - J Chromatogr B Analyt Technol Biomed Life Sci
VL - 925
N2 - We present a sensitive validated LC-MS/MS assay for the simultaneous determination of cabazitaxel and docetaxel in human plasma, with calibration ranges of 1.0-150 ng/mL for cabazitaxel and 0.1-15 ng/mL for docetaxel. Sample pretreatment consisted of liquid-liquid extraction with tert-butyl methyl ether. Chromatographic separation was achieved on a Zorbax Extend C18 column using a gradient mixture of 10mM ammonium hydroxide and methanol. Mass detection was carried out by turbo ion spray ionization in positive ion multiple reaction monitoring mode. All inter-day accuracies and precisions were within ±15% of the nominal value and within ±20% at the lower limit of quantitation. Demethylations of cabazitaxel yielding the metabolites RPR112698 and RPR123142 were monitored semi-quantitatively and quantified as ng docetaxel equivalents. Plasma samples of a prostate cancer patient treated with cabazitaxel were analyzed to demonstrate the usefulness of the presented assay for clinical drug monitoring. In conclusion, this method can be applied to support clinical pharmacokinetic studies with the novel anticancer drug cabazitaxel.
SN - 1873-376X
UR - https://www.unboundmedicine.com/medline/citation/23542607/Quantification_of_cabazitaxel_its_metabolite_docetaxel_and_the_determination_of_the_demethylated_metabolites_RPR112698_and_RPR123142_as_docetaxel_equivalents_in_human_plasma_by_liquid_chromatography_tandem_mass_spectrometry_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1570-0232(13)00137-2
DB - PRIME
DP - Unbound Medicine
ER -
