Tags

Type your tag names separated by a space and hit enter

Markers of disease severity are associated with malnutrition in Parkinson's disease.
PLoS One. 2013; 8(3):e57986.Plos

Abstract

OBJECTIVE

In Parkinson's disease (PD), commonly reported risk factors for malnutrition in other populations commonly occur. Few studies have explored which of these factors are of particular importance in malnutrition in PD. The aim was to identify the determinants of nutritional status in people with Parkinson's disease (PWP).

METHODS

Community-dwelling PWP (>18 years) were recruited (n = 125; 73M/52F; Mdn 70 years). Self-report assessments included Beck's Depression Inventory (BDI), Spielberger Trait Anxiety Inventory (STAI), Scales for Outcomes in Parkinson's disease-Autonomic (SCOPA-AUT), Modified Constipation Assessment Scale (MCAS) and Freezing of Gait Questionnaire (FOG-Q). Information about age, PD duration, medications, co-morbid conditions and living situation was obtained. Addenbrooke's Cognitive Examination (ACE-R), Unified Parkinson's Disease Rating Scale (UPDRS) II and UPDRS III were performed. Nutritional status was assessed using the Subjective Global Assessment (SGA) as part of the scored Patient-Generated Subjective Global Assessment (PG-SGA).

RESULTS

Nineteen (15%) were malnourished (SGA-B). Median PG-SGA score was 3. More of the malnourished were elderly (84% vs. 71%) and had more severe disease (H&Y: 21% vs. 5%). UPDRS II and UPDRS III scores and levodopa equivalent daily dose (LEDD)/body weight (mg/kg) were significantly higher in the malnourished (Mdn 18 vs. 15; 20 vs. 15; 10.1 vs. 7.6 respectively). Regression analyses revealed older age at diagnosis, higher LEDD/body weight (mg/kg), greater UPDRS III score, lower STAI score and higher BDI score as significant predictors of malnutrition (SGA-B). Living alone and higher BDI and UPDRS III scores were significant predictors of a higher log-adjusted PG-SGA score.

CONCLUSIONS

In this sample of PWP, the rate of malnutrition was higher than that previously reported in the general community. Nutrition screening should occur regularly in those with more severe disease and depression. Community support should be provided to PWP living alone. Dopaminergic medication should be reviewed with body weight changes.

Authors+Show Affiliations

School of Exercise and Nutrition Sciences, Queensland University of Technology, Brisbane, Queensland, Australia. jamie.sheard@qut.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23544041

Citation

Sheard, Jamie M., et al. "Markers of Disease Severity Are Associated With Malnutrition in Parkinson's Disease." PloS One, vol. 8, no. 3, 2013, pp. e57986.
Sheard JM, Ash S, Mellick GD, et al. Markers of disease severity are associated with malnutrition in Parkinson's disease. PLoS One. 2013;8(3):e57986.
Sheard, J. M., Ash, S., Mellick, G. D., Silburn, P. A., & Kerr, G. K. (2013). Markers of disease severity are associated with malnutrition in Parkinson's disease. PloS One, 8(3), e57986. https://doi.org/10.1371/journal.pone.0057986
Sheard JM, et al. Markers of Disease Severity Are Associated With Malnutrition in Parkinson's Disease. PLoS One. 2013;8(3):e57986. PubMed PMID: 23544041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Markers of disease severity are associated with malnutrition in Parkinson's disease. AU - Sheard,Jamie M, AU - Ash,Susan, AU - Mellick,George D, AU - Silburn,Peter A, AU - Kerr,Graham K, Y1 - 2013/03/27/ PY - 2012/08/13/received PY - 2013/01/30/accepted PY - 2013/4/2/entrez PY - 2013/4/2/pubmed PY - 2013/9/18/medline SP - e57986 EP - e57986 JF - PloS one JO - PLoS One VL - 8 IS - 3 N2 - OBJECTIVE: In Parkinson's disease (PD), commonly reported risk factors for malnutrition in other populations commonly occur. Few studies have explored which of these factors are of particular importance in malnutrition in PD. The aim was to identify the determinants of nutritional status in people with Parkinson's disease (PWP). METHODS: Community-dwelling PWP (>18 years) were recruited (n = 125; 73M/52F; Mdn 70 years). Self-report assessments included Beck's Depression Inventory (BDI), Spielberger Trait Anxiety Inventory (STAI), Scales for Outcomes in Parkinson's disease-Autonomic (SCOPA-AUT), Modified Constipation Assessment Scale (MCAS) and Freezing of Gait Questionnaire (FOG-Q). Information about age, PD duration, medications, co-morbid conditions and living situation was obtained. Addenbrooke's Cognitive Examination (ACE-R), Unified Parkinson's Disease Rating Scale (UPDRS) II and UPDRS III were performed. Nutritional status was assessed using the Subjective Global Assessment (SGA) as part of the scored Patient-Generated Subjective Global Assessment (PG-SGA). RESULTS: Nineteen (15%) were malnourished (SGA-B). Median PG-SGA score was 3. More of the malnourished were elderly (84% vs. 71%) and had more severe disease (H&Y: 21% vs. 5%). UPDRS II and UPDRS III scores and levodopa equivalent daily dose (LEDD)/body weight (mg/kg) were significantly higher in the malnourished (Mdn 18 vs. 15; 20 vs. 15; 10.1 vs. 7.6 respectively). Regression analyses revealed older age at diagnosis, higher LEDD/body weight (mg/kg), greater UPDRS III score, lower STAI score and higher BDI score as significant predictors of malnutrition (SGA-B). Living alone and higher BDI and UPDRS III scores were significant predictors of a higher log-adjusted PG-SGA score. CONCLUSIONS: In this sample of PWP, the rate of malnutrition was higher than that previously reported in the general community. Nutrition screening should occur regularly in those with more severe disease and depression. Community support should be provided to PWP living alone. Dopaminergic medication should be reviewed with body weight changes. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23544041/Markers_of_disease_severity_are_associated_with_malnutrition_in_Parkinson's_disease_ L2 - https://dx.plos.org/10.1371/journal.pone.0057986 DB - PRIME DP - Unbound Medicine ER -