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Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery.
Carbohydr Polym. 2013 Apr 15; 94(1):456-67.CP

Abstract

A novel interpenetrating polymer network (IPN) microspheres of locust bean gum (LBG) and poly (vinyl alcohol) (PVA) was developed for oral controlled release of buflomedil hydrochloride (BH) by emulsion crosslinking method using glutaraldehyde as crosslinker. The effects of gum-polymer ratio, concentration of crosslinker and internal phase viscosity were evaluated thoroughly. Drug entrapment efficiency, particle size distribution, swelling property and in vitro release characteristics with kinetic modelling of microspheres were evaluated. The microspheres were characterised by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), solid state C(13) NMR, X-ray diffraction study (XRD) and differential scanning colorimetry (DSC). The microspheres showed control release property without showing any incompatibility in IPN device. Hence, IPN microspheres of LBG and PVA can be used as a potential carrier for controlled oral delivery of highly water soluble drugs like BH.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835 215, Jharkhand, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23544563

Citation

Kaity, Santanu, et al. "Interpenetrating Polymer Network of Locust Bean Gum-poly (vinyl Alcohol) for Controlled Release Drug Delivery." Carbohydrate Polymers, vol. 94, no. 1, 2013, pp. 456-67.
Kaity S, Isaac J, Ghosh A. Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery. Carbohydr Polym. 2013;94(1):456-67.
Kaity, S., Isaac, J., & Ghosh, A. (2013). Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery. Carbohydrate Polymers, 94(1), 456-67. https://doi.org/10.1016/j.carbpol.2013.01.070
Kaity S, Isaac J, Ghosh A. Interpenetrating Polymer Network of Locust Bean Gum-poly (vinyl Alcohol) for Controlled Release Drug Delivery. Carbohydr Polym. 2013 Apr 15;94(1):456-67. PubMed PMID: 23544563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery. AU - Kaity,Santanu, AU - Isaac,Jinu, AU - Ghosh,Animesh, Y1 - 2013/01/30/ PY - 2012/03/07/received PY - 2012/12/14/revised PY - 2013/01/23/accepted PY - 2013/4/3/entrez PY - 2013/4/3/pubmed PY - 2013/9/21/medline SP - 456 EP - 67 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 94 IS - 1 N2 - A novel interpenetrating polymer network (IPN) microspheres of locust bean gum (LBG) and poly (vinyl alcohol) (PVA) was developed for oral controlled release of buflomedil hydrochloride (BH) by emulsion crosslinking method using glutaraldehyde as crosslinker. The effects of gum-polymer ratio, concentration of crosslinker and internal phase viscosity were evaluated thoroughly. Drug entrapment efficiency, particle size distribution, swelling property and in vitro release characteristics with kinetic modelling of microspheres were evaluated. The microspheres were characterised by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), solid state C(13) NMR, X-ray diffraction study (XRD) and differential scanning colorimetry (DSC). The microspheres showed control release property without showing any incompatibility in IPN device. Hence, IPN microspheres of LBG and PVA can be used as a potential carrier for controlled oral delivery of highly water soluble drugs like BH. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/23544563/Interpenetrating_polymer_network_of_locust_bean_gum_poly__vinyl_alcohol__for_controlled_release_drug_delivery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0144-8617(13)00087-8 DB - PRIME DP - Unbound Medicine ER -