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Lack of relationship between birth conditions and allergic disorders in Japanese children aged 3 years.
J Asthma. 2013 Aug; 50(6):555-9.JA

Abstract

BACKGROUND

The current cross-sectional study examined the associations between low birth weight (LBW), preterm birth, and small-for-gestational-age (SGA) and the prevalence of wheeze, asthma, and eczema in Japanese children aged 3 years.

METHODS

Study subjects were 2004 children. All data were obtained using a questionnaire. Outcomes were defined according to the criteria of the International Study of Asthma and Allergies in Childhood. Adjustment was made for sex, number of siblings, breastfeeding duration, paternal and maternal educational level, paternal and maternal history of allergic disorders, maternal smoking during pregnancy, secondhand smoke exposure at home, and gestational age at birth.

RESULTS

The prevalence of wheeze, asthma, and eczema in the previous 12 months were 22.1%, 9.0%, and 17.5%, respectively, and 8.4% were classified as LBW (<2500 g), 4.7% as preterm birth (<37 weeks), and 7.1% as SGA (<10th percentile). There were no significant associations between LBW, preterm birth, or SGA and the prevalence of wheeze, asthma, or eczema. A positive relationship between preterm birth and asthma was of borderline significance in children whose mothers had smoked during pregnancy (adjusted OR: 4.71 [95% CI: 0.97-21.39]), but not in those whose mothers had never smoked during pregnancy; the multiplicative interaction between preterm birth and maternal smoking during pregnancy with respect to asthma was significant (p = .04).

CONCLUSIONS

The current study failed to detect significant associations between birth conditions and allergic disorders. Nevertheless, we did find evidence for an interaction between preterm birth and maternal smoking during pregnancy affecting asthma.

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Authors+Show Affiliations

Miyake Y
Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan. miyake-y@fukuoka-u.ac.jp
Tanaka K
No affiliation info available

MeSH

Asian Continental Ancestry GroupAsthmaBirth WeightBreast FeedingChild, PreschoolEczemaEnvironmental ExposureFathersFemaleGestational AgeHumansJapanMaleMaternal-Fetal ExchangeMothersOdds RatioPregnancyPrevalenceRespiratory SoundsSmokingSurveys and QuestionnairesTobacco Smoke Pollution

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23544740

Citation

Miyake, Yoshihiro, and Keiko Tanaka. "Lack of Relationship Between Birth Conditions and Allergic Disorders in Japanese Children Aged 3 Years." The Journal of Asthma : Official Journal of the Association for the Care of Asthma, vol. 50, no. 6, 2013, pp. 555-9.
Miyake Y, Tanaka K. Lack of relationship between birth conditions and allergic disorders in Japanese children aged 3 years. J Asthma. 2013;50(6):555-9.
Miyake, Y., & Tanaka, K. (2013). Lack of relationship between birth conditions and allergic disorders in Japanese children aged 3 years. The Journal of Asthma : Official Journal of the Association for the Care of Asthma, 50(6), 555-9. https://doi.org/10.3109/02770903.2013.790422
Miyake Y, Tanaka K. Lack of Relationship Between Birth Conditions and Allergic Disorders in Japanese Children Aged 3 Years. J Asthma. 2013;50(6):555-9. PubMed PMID: 23544740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of relationship between birth conditions and allergic disorders in Japanese children aged 3 years. AU - Miyake,Yoshihiro, AU - Tanaka,Keiko, Y1 - 2013/04/29/ PY - 2013/4/3/entrez PY - 2013/4/3/pubmed PY - 2013/9/17/medline SP - 555 EP - 9 JF - The Journal of asthma : official journal of the Association for the Care of Asthma JO - J Asthma VL - 50 IS - 6 N2 - BACKGROUND: The current cross-sectional study examined the associations between low birth weight (LBW), preterm birth, and small-for-gestational-age (SGA) and the prevalence of wheeze, asthma, and eczema in Japanese children aged 3 years. METHODS: Study subjects were 2004 children. All data were obtained using a questionnaire. Outcomes were defined according to the criteria of the International Study of Asthma and Allergies in Childhood. Adjustment was made for sex, number of siblings, breastfeeding duration, paternal and maternal educational level, paternal and maternal history of allergic disorders, maternal smoking during pregnancy, secondhand smoke exposure at home, and gestational age at birth. RESULTS: The prevalence of wheeze, asthma, and eczema in the previous 12 months were 22.1%, 9.0%, and 17.5%, respectively, and 8.4% were classified as LBW (<2500 g), 4.7% as preterm birth (<37 weeks), and 7.1% as SGA (<10th percentile). There were no significant associations between LBW, preterm birth, or SGA and the prevalence of wheeze, asthma, or eczema. A positive relationship between preterm birth and asthma was of borderline significance in children whose mothers had smoked during pregnancy (adjusted OR: 4.71 [95% CI: 0.97-21.39]), but not in those whose mothers had never smoked during pregnancy; the multiplicative interaction between preterm birth and maternal smoking during pregnancy with respect to asthma was significant (p = .04). CONCLUSIONS: The current study failed to detect significant associations between birth conditions and allergic disorders. Nevertheless, we did find evidence for an interaction between preterm birth and maternal smoking during pregnancy affecting asthma. SN - 1532-4303 UR - https://www.unboundmedicine.com/medline/citation/23544740/Lack_of_relationship_between_birth_conditions_and_allergic_disorders_in_Japanese_children_aged_3_years_ L2 - https://www.tandfonline.com/doi/full/10.3109/02770903.2013.790422 DB - PRIME DP - Unbound Medicine ER -