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Hypertriglyceridemic waist phenotype: association with metabolic abnormalities in adolescents.
J Pediatr (Rio J). 2013 Jan-Feb; 89(1):56-63.JP

Abstract

OBJECTIVE

This study aimed to identify the prevalence of hypertriglyceridemic waist (HTW) phenotype, and to evaluate its association with metabolic abnormalities in adolescents of low socioeconomic status.

METHOD

This was a cross-sectional study with a random sample of 1,076 adolescents between 11 and 17 years, of both genders, from public schools. The participants underwent anthropometric measurements (weight, height, and waist circumference), and levels of total cholesterol, low-density-lipoprotein cholesterol (LDL-C), high-density-lipoprotein cholesterol (HDL-C), non-HDL cholesterol, triglyceride (TG), and fasting glucose were measured. Information regarding the socioeconomic status of the participants' families was obtained. The HTW phenotype was defined by the simultaneous presence of increased waist circumference (≥ 90(th) percentile for age and gender) and serum triglyceride levels (≥ 100mg/dL). A logistic regression analysis was used to evaluate the associations of interest.

RESULTS

The prevalence of HTW phenotype was 7.2% among the adolescents, being higher in the presence of obesity (63.4%) and high levels of non-HDL cholesterol (16.6%) and LDL-C (13.7%). The bivariate analysis indicated that, of the metabolic variables, only blood glucose was not associated with the HTW phenotype. Multivariate analysis adjusted for age and gender indicated that the HTW phenotype was positively associated with high non-HDL cholesterol (odds ratio: 7.0; 95% CI: 3.9-12.6) and low HDL-C levels (odds ratio: 2.7; 95% CI: 1.5-4.8).

CONCLUSIONS

This study demonstrated that the HTW phenotype was associated with an atherogenic lipid profile, and this phenotype is suggested as a screening tool to identify adolescents with metabolic alterations.

Authors+Show Affiliations

Postgraduate Program in Medicine and Health, Universidade Federal da Bahia Medical School, Salvador, BA, Brazil. estercmachado@yahoo.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23544811

Citation

Conceição-Machado, Maria Ester P da, et al. "Hypertriglyceridemic Waist Phenotype: Association With Metabolic Abnormalities in Adolescents." Jornal De Pediatria, vol. 89, no. 1, 2013, pp. 56-63.
Conceição-Machado ME, Silva LR, Santana ML, et al. Hypertriglyceridemic waist phenotype: association with metabolic abnormalities in adolescents. J Pediatr (Rio J). 2013;89(1):56-63.
Conceição-Machado, M. E., Silva, L. R., Santana, M. L., Pinto, E. J., Silva, R. d. e. . C., Moraes, L. T., Couto, R. D., & Assis, A. M. (2013). Hypertriglyceridemic waist phenotype: association with metabolic abnormalities in adolescents. Jornal De Pediatria, 89(1), 56-63. https://doi.org/10.1016/j.jped.2013.02.009
Conceição-Machado ME, et al. Hypertriglyceridemic Waist Phenotype: Association With Metabolic Abnormalities in Adolescents. J Pediatr (Rio J). 2013 Jan-Feb;89(1):56-63. PubMed PMID: 23544811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypertriglyceridemic waist phenotype: association with metabolic abnormalities in adolescents. AU - Conceição-Machado,Maria Ester P da, AU - Silva,Luciana R, AU - Santana,Mônica Leila P, AU - Pinto,Elizabete J, AU - Silva,Rita de Cássia R, AU - Moraes,Lia Terezinha L P, AU - Couto,Ricardo D, AU - Assis,Ana Marlúcia O, PY - 2012/05/08/received PY - 2012/08/08/accepted PY - 2013/4/3/entrez PY - 2013/4/3/pubmed PY - 2013/8/3/medline SP - 56 EP - 63 JF - Jornal de pediatria JO - J Pediatr (Rio J) VL - 89 IS - 1 N2 - OBJECTIVE: This study aimed to identify the prevalence of hypertriglyceridemic waist (HTW) phenotype, and to evaluate its association with metabolic abnormalities in adolescents of low socioeconomic status. METHOD: This was a cross-sectional study with a random sample of 1,076 adolescents between 11 and 17 years, of both genders, from public schools. The participants underwent anthropometric measurements (weight, height, and waist circumference), and levels of total cholesterol, low-density-lipoprotein cholesterol (LDL-C), high-density-lipoprotein cholesterol (HDL-C), non-HDL cholesterol, triglyceride (TG), and fasting glucose were measured. Information regarding the socioeconomic status of the participants' families was obtained. The HTW phenotype was defined by the simultaneous presence of increased waist circumference (≥ 90(th) percentile for age and gender) and serum triglyceride levels (≥ 100mg/dL). A logistic regression analysis was used to evaluate the associations of interest. RESULTS: The prevalence of HTW phenotype was 7.2% among the adolescents, being higher in the presence of obesity (63.4%) and high levels of non-HDL cholesterol (16.6%) and LDL-C (13.7%). The bivariate analysis indicated that, of the metabolic variables, only blood glucose was not associated with the HTW phenotype. Multivariate analysis adjusted for age and gender indicated that the HTW phenotype was positively associated with high non-HDL cholesterol (odds ratio: 7.0; 95% CI: 3.9-12.6) and low HDL-C levels (odds ratio: 2.7; 95% CI: 1.5-4.8). CONCLUSIONS: This study demonstrated that the HTW phenotype was associated with an atherogenic lipid profile, and this phenotype is suggested as a screening tool to identify adolescents with metabolic alterations. SN - 1678-4782 UR - https://www.unboundmedicine.com/medline/citation/23544811/Hypertriglyceridemic_waist_phenotype:_association_with_metabolic_abnormalities_in_adolescents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-7557(13)00010-7 DB - PRIME DP - Unbound Medicine ER -