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Genetics of attention-deficit/hyperactivity disorder: current findings and future directions.

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder affecting 5.29% of children worldwide. It presents a heterogeneous clinical expression, and both environmental and genetic factors are involved in the etiology. Despite high heritability estimates, identification of genes that confer susceptibility to ADHD has been a slow and difficult process. The first genetic studies targeted dopaminergic genes, but the effects were small and only explained a small portion of ADHD heritability. Recent studies focus on the identification of novel genes and pathways that may underlie ADHD. The main goal of this review is to present evidence from genome-wide association, copy number variation and family-based studies of genetic susceptibility to ADHD. The challenges involved to disclose ADHD susceptibility genes will be reviewed in order to provide directions for future studies.

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  • Authors+Show Affiliations

    ,

    Department of Genetics, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

    , , ,

    Source

    Expert review of neurotherapeutics 13:4 2013 Apr pg 435-45

    MeSH

    Attention Deficit Disorder with Hyperactivity
    DNA Copy Number Variations
    Genetic Linkage
    Genetic Predisposition to Disease
    Genome-Wide Association Study
    Humans

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    23545057

    Citation

    Akutagava-Martins, Glaucia Chiyoko, et al. "Genetics of Attention-deficit/hyperactivity Disorder: Current Findings and Future Directions." Expert Review of Neurotherapeutics, vol. 13, no. 4, 2013, pp. 435-45.
    Akutagava-Martins GC, Salatino-Oliveira A, Kieling CC, et al. Genetics of attention-deficit/hyperactivity disorder: current findings and future directions. Expert Rev Neurother. 2013;13(4):435-45.
    Akutagava-Martins, G. C., Salatino-Oliveira, A., Kieling, C. C., Rohde, L. A., & Hutz, M. H. (2013). Genetics of attention-deficit/hyperactivity disorder: current findings and future directions. Expert Review of Neurotherapeutics, 13(4), pp. 435-45. doi:10.1586/ern.13.30.
    Akutagava-Martins GC, et al. Genetics of Attention-deficit/hyperactivity Disorder: Current Findings and Future Directions. Expert Rev Neurother. 2013;13(4):435-45. PubMed PMID: 23545057.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Genetics of attention-deficit/hyperactivity disorder: current findings and future directions. AU - Akutagava-Martins,Glaucia Chiyoko, AU - Salatino-Oliveira,Angelica, AU - Kieling,Christian Costa, AU - Rohde,Luis Augusto, AU - Hutz,Mara Helena, PY - 2013/4/3/entrez PY - 2013/4/3/pubmed PY - 2013/9/21/medline SP - 435 EP - 45 JF - Expert review of neurotherapeutics JO - Expert Rev Neurother VL - 13 IS - 4 N2 - Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder affecting 5.29% of children worldwide. It presents a heterogeneous clinical expression, and both environmental and genetic factors are involved in the etiology. Despite high heritability estimates, identification of genes that confer susceptibility to ADHD has been a slow and difficult process. The first genetic studies targeted dopaminergic genes, but the effects were small and only explained a small portion of ADHD heritability. Recent studies focus on the identification of novel genes and pathways that may underlie ADHD. The main goal of this review is to present evidence from genome-wide association, copy number variation and family-based studies of genetic susceptibility to ADHD. The challenges involved to disclose ADHD susceptibility genes will be reviewed in order to provide directions for future studies. SN - 1744-8360 UR - https://www.unboundmedicine.com/medline/citation/23545057/Genetics_of_attention_deficit/hyperactivity_disorder:_current_findings_and_future_directions_ L2 - http://www.tandfonline.com/doi/full/10.1586/ern.13.30 DB - PRIME DP - Unbound Medicine ER -