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Antioxidant and anti-inflammatory activities of the phenolic extracts of Sapium sebiferum (L.) Roxb. leaves.
J Ethnopharmacol. 2013 May 20; 147(2):517-24.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

The leaves of Sapium sebiferum have long been used in Traditional Chinese Medicine (TCM) for the treatment of eczema, shingles, edema, swelling, ascites, scabs, and snakebites, among other maladies.

AIM OF THIS STUDY

The present study aimed to investigate the antioxidant and anti-inflammatory effects of the phenolic extracts of Sapium sebiferum leaves using in vitro and in vivo models.

MATERIALS AND METHODS

The in vitro antioxidant activities of the extracts were measured using common chemical methods (total phenolic content; total flavonoid content; scavenging of DPPH·, ABTS+·, superoxide, and nitrite radicals; reducing power; β-carotene bleaching; and FTC assays). The in vivo topical anti-inflammatory activities were tested using the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced dermatitis animal model. The SOD and CAT activities and the GSH content of ear tissue were also determined using test kits.

RESULTS

The extracts of Sapium sebiferum leaves exhibited strong in vitro antioxidant activities. They also showed significant (P<0.001) and dose-dependent anti-inflammatory activities in an acute dermatitis model at the doses of 0.03 mg/ear, 0.1mg/ear, and 0.3mg/ear. The application of Sapium sebiferum leaf extracts increased the SOD and CAT activities and the GSH content relative to those of the TPA treatment group. The anti-inflammatory effect of the Sapium sebiferum leaf extract was positively correlated with its antioxidant activity.

CONCLUSION

These results demonstrate that Sapium sebiferum leaf extract is an effective anti-inflammatory agent in the TPA-induced dermatitis model, and its anti-inflammatory effect is related, at least in part, to its antioxidant activity.

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Authors+Show Affiliations

Fu R
College of Life Sciences, Sichuan University, Sichuan Key Laboratory of Resource Biology and Biopharmaceutical Engineering, Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Chengdu, PR China.
Zhang YT
No affiliation info available
Guo YR
No affiliation info available
Huang QL
No affiliation info available
Peng T
No affiliation info available
Xu Y
No affiliation info available
Tang L
No affiliation info available
Chen F
No affiliation info available

MeSH

AnimalsAnti-Inflammatory AgentsAntioxidantsCatalaseDermatitis, ContactEdemaFlavonoidsGlutathioneMaleMiceNitritesPhenolsPhytotherapyPlant ExtractsPlant LeavesSapiumSuperoxide DismutaseSuperoxidesTetradecanoylphorbol Acetate

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23545454

Citation

Fu, Rao, et al. "Antioxidant and Anti-inflammatory Activities of the Phenolic Extracts of Sapium Sebiferum (L.) Roxb. Leaves." Journal of Ethnopharmacology, vol. 147, no. 2, 2013, pp. 517-24.
Fu R, Zhang YT, Guo YR, et al. Antioxidant and anti-inflammatory activities of the phenolic extracts of Sapium sebiferum (L.) Roxb. leaves. J Ethnopharmacol. 2013;147(2):517-24.
Fu, R., Zhang, Y. T., Guo, Y. R., Huang, Q. L., Peng, T., Xu, Y., Tang, L., & Chen, F. (2013). Antioxidant and anti-inflammatory activities of the phenolic extracts of Sapium sebiferum (L.) Roxb. leaves. Journal of Ethnopharmacology, 147(2), 517-24. https://doi.org/10.1016/j.jep.2013.03.058
Fu R, et al. Antioxidant and Anti-inflammatory Activities of the Phenolic Extracts of Sapium Sebiferum (L.) Roxb. Leaves. J Ethnopharmacol. 2013 May 20;147(2):517-24. PubMed PMID: 23545454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and anti-inflammatory activities of the phenolic extracts of Sapium sebiferum (L.) Roxb. leaves. AU - Fu,Rao, AU - Zhang,Yu-Ting, AU - Guo,Yi-Ran, AU - Huang,Qiu-Lan, AU - Peng,Tong, AU - Xu,Ying, AU - Tang,Lin, AU - Chen,Fang, Y1 - 2013/03/30/ PY - 2013/01/11/received PY - 2013/03/15/revised PY - 2013/03/22/accepted PY - 2013/4/3/entrez PY - 2013/4/3/pubmed PY - 2013/10/24/medline SP - 517 EP - 24 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 147 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Sapium sebiferum have long been used in Traditional Chinese Medicine (TCM) for the treatment of eczema, shingles, edema, swelling, ascites, scabs, and snakebites, among other maladies. AIM OF THIS STUDY: The present study aimed to investigate the antioxidant and anti-inflammatory effects of the phenolic extracts of Sapium sebiferum leaves using in vitro and in vivo models. MATERIALS AND METHODS: The in vitro antioxidant activities of the extracts were measured using common chemical methods (total phenolic content; total flavonoid content; scavenging of DPPH·, ABTS+·, superoxide, and nitrite radicals; reducing power; β-carotene bleaching; and FTC assays). The in vivo topical anti-inflammatory activities were tested using the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced dermatitis animal model. The SOD and CAT activities and the GSH content of ear tissue were also determined using test kits. RESULTS: The extracts of Sapium sebiferum leaves exhibited strong in vitro antioxidant activities. They also showed significant (P<0.001) and dose-dependent anti-inflammatory activities in an acute dermatitis model at the doses of 0.03 mg/ear, 0.1mg/ear, and 0.3mg/ear. The application of Sapium sebiferum leaf extracts increased the SOD and CAT activities and the GSH content relative to those of the TPA treatment group. The anti-inflammatory effect of the Sapium sebiferum leaf extract was positively correlated with its antioxidant activity. CONCLUSION: These results demonstrate that Sapium sebiferum leaf extract is an effective anti-inflammatory agent in the TPA-induced dermatitis model, and its anti-inflammatory effect is related, at least in part, to its antioxidant activity. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/23545454/Antioxidant_and_anti_inflammatory_activities_of_the_phenolic_extracts_of_Sapium_sebiferum__L___Roxb__leaves_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(13)00214-6 DB - PRIME DP - Unbound Medicine ER -