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Medicinal flowers. XXXVIII. structures of acylated sucroses and inhibitory effects of constituents on aldose reducatase from the flower buds of Prunus mume.

Abstract

The methanolic extract from the flower buds of Prunus mume, cultivated in Zhejiang province, China, showed an inhibitory effect on aldose reductase. From the methanolic extract, five new acylated sucroses, mumeoses F-J, were isolated together with 29 known compounds. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of the isolated compounds on aldose reductase were also investigated. Acylated quinic acid analogs, which are one of the major compounds of the flower buds of P. mume, were shown to substantially inhibit aldose reductase. In particular, mumeic acid-A was found to exhibit a potent inhibitory effect [IC50=0.4 µm].

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  • Authors+Show Affiliations

    ,

    Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, Japan.

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    Source

    MeSH

    Acylation
    Aldehyde Reductase
    Animals
    Flowers
    Lens Cortex, Crystalline
    Magnetic Resonance Spectroscopy
    Methanol
    Molecular Conformation
    Plant Extracts
    Plants, Medicinal
    Protein Binding
    Prunus
    Quinic Acid
    Rats
    Sucrose

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23546004

    Citation

    Fujimoto, Katsuyoshi, et al. "Medicinal Flowers. XXXVIII. Structures of Acylated Sucroses and Inhibitory Effects of Constituents On Aldose Reducatase From the Flower Buds of Prunus Mume." Chemical & Pharmaceutical Bulletin, vol. 61, no. 4, 2013, pp. 445-51.
    Fujimoto K, Nakamura S, Matsumoto T, et al. Medicinal flowers. XXXVIII. structures of acylated sucroses and inhibitory effects of constituents on aldose reducatase from the flower buds of Prunus mume. Chem Pharm Bull. 2013;61(4):445-51.
    Fujimoto, K., Nakamura, S., Matsumoto, T., Ohta, T., Ogawa, K., Tamura, H., ... Yoshikawa, M. (2013). Medicinal flowers. XXXVIII. structures of acylated sucroses and inhibitory effects of constituents on aldose reducatase from the flower buds of Prunus mume. Chemical & Pharmaceutical Bulletin, 61(4), pp. 445-51.
    Fujimoto K, et al. Medicinal Flowers. XXXVIII. Structures of Acylated Sucroses and Inhibitory Effects of Constituents On Aldose Reducatase From the Flower Buds of Prunus Mume. Chem Pharm Bull. 2013;61(4):445-51. PubMed PMID: 23546004.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Medicinal flowers. XXXVIII. structures of acylated sucroses and inhibitory effects of constituents on aldose reducatase from the flower buds of Prunus mume. AU - Fujimoto,Katsuyoshi, AU - Nakamura,Seikou, AU - Matsumoto,Takahiro, AU - Ohta,Tomoe, AU - Ogawa,Keiko, AU - Tamura,Haruka, AU - Matsuda,Hisashi, AU - Yoshikawa,Masayuki, PY - 2013/4/3/entrez PY - 2013/4/3/pubmed PY - 2013/10/23/medline SP - 445 EP - 51 JF - Chemical & pharmaceutical bulletin JO - Chem. Pharm. Bull. VL - 61 IS - 4 N2 - The methanolic extract from the flower buds of Prunus mume, cultivated in Zhejiang province, China, showed an inhibitory effect on aldose reductase. From the methanolic extract, five new acylated sucroses, mumeoses F-J, were isolated together with 29 known compounds. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of the isolated compounds on aldose reductase were also investigated. Acylated quinic acid analogs, which are one of the major compounds of the flower buds of P. mume, were shown to substantially inhibit aldose reductase. In particular, mumeic acid-A was found to exhibit a potent inhibitory effect [IC50=0.4 µm]. SN - 1347-5223 UR - https://www.unboundmedicine.com/medline/citation/23546004/Medicinal_flowers__XXXVIII__structures_of_acylated_sucroses_and_inhibitory_effects_of_constituents_on_aldose_reducatase_from_the_flower_buds_of_Prunus_mume_ L2 - http://joi.jlc.jst.go.jp/DN/JST.JSTAGE/cpb/c12-01068?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -