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Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis.
Rev Esp Enferm Dig 2013; 105(1):19-36RE

Abstract

BACKGROUND AND OBJECTIVES

immune system alteration in irritable bowel syndrome (IBS) patients may be modulated by probiotics. We assessed the efficacy of some probiotic species in alleviating characteristic IBS symptoms.

MATERIAL AND METHODS

a meta-analysis of all identified randomized controlled trials comparing probiotics with placebo in treating IBS symptoms was performed with continuous data summarized using standardized mean differences (SMDs) with 95% confidence intervals (95% CIs), where appropriate. The random-effects model was employed in cases of heterogeneity; otherwise, fixed-effects models were used.

RESULTS

meta-analysis was performed with 10 of 24 studies identified as suitable for inclusion. Probiotics improved pain scores if they contained Bifidobacterium breve (SMD, - 0.34; 95% CI, - 0.66; -0.02), Bifidobacterium longum (SMD, -0.48; 95% CI, - 0.91; -0.06), or Lactobacillus acidophilus (SMD, -0.31; 95% CI, -0.61; -0.01) species. Distension scores were improved by probiotics containing B. breve (SMD, -0.45; 95% CI, -0.77; -0.13), Bifidobacterium infantis, Lactobacillus casei, or Lactobacillus plantarum (SMD, -0.53; 95% CI, -1.00; -0.06) species. All probiotic species tested improved flatulence: B. breve (SMD, -0.42; 95% CI, -0.75;- 0.10), B. infantis, L. casei, L. plantarum (SMD, -0.60; 95% CI, -1.07; -0.13), B. longum, L. acidophilus, Lactobacillus bulgaricus, and Streptococcus salivarius ssp. thermophilus (SMD, -0.61; 95% CI, -1.01; -0.21). There was not a clear positive effect of probiotics concerning the quality of life.

CONCLUSIONS

some probiotics are an effective therapeutic option for IBS patients, and the effects on each IBS symptom are likely species-specific. Future studies must focus on the role of probiotics in modulating intestinal microbiota and the immune system while considering individual patient symptom profiles.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

23548007

Citation

Ortiz-Lucas, María, et al. "Effect of Probiotic Species On Irritable Bowel Syndrome Symptoms: a Bring Up to Date Meta-analysis." Revista Espanola De Enfermedades Digestivas : Organo Oficial De La Sociedad Espanola De Patologia Digestiva, vol. 105, no. 1, 2013, pp. 19-36.
Ortiz-Lucas M, Tobías A, Saz P, et al. Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. Rev Esp Enferm Dig. 2013;105(1):19-36.
Ortiz-Lucas, M., Tobías, A., Saz, P., & Sebastián, J. J. (2013). Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. Revista Espanola De Enfermedades Digestivas : Organo Oficial De La Sociedad Espanola De Patologia Digestiva, 105(1), pp. 19-36.
Ortiz-Lucas M, et al. Effect of Probiotic Species On Irritable Bowel Syndrome Symptoms: a Bring Up to Date Meta-analysis. Rev Esp Enferm Dig. 2013;105(1):19-36. PubMed PMID: 23548007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. AU - Ortiz-Lucas,María, AU - Tobías,Aurelio, AU - Saz,Pablo, AU - Sebastián,Juan José, PY - 2013/4/4/entrez PY - 2013/4/4/pubmed PY - 2015/7/8/medline SP - 19 EP - 36 JF - Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva JO - Rev Esp Enferm Dig VL - 105 IS - 1 N2 - BACKGROUND AND OBJECTIVES: immune system alteration in irritable bowel syndrome (IBS) patients may be modulated by probiotics. We assessed the efficacy of some probiotic species in alleviating characteristic IBS symptoms. MATERIAL AND METHODS: a meta-analysis of all identified randomized controlled trials comparing probiotics with placebo in treating IBS symptoms was performed with continuous data summarized using standardized mean differences (SMDs) with 95% confidence intervals (95% CIs), where appropriate. The random-effects model was employed in cases of heterogeneity; otherwise, fixed-effects models were used. RESULTS: meta-analysis was performed with 10 of 24 studies identified as suitable for inclusion. Probiotics improved pain scores if they contained Bifidobacterium breve (SMD, - 0.34; 95% CI, - 0.66; -0.02), Bifidobacterium longum (SMD, -0.48; 95% CI, - 0.91; -0.06), or Lactobacillus acidophilus (SMD, -0.31; 95% CI, -0.61; -0.01) species. Distension scores were improved by probiotics containing B. breve (SMD, -0.45; 95% CI, -0.77; -0.13), Bifidobacterium infantis, Lactobacillus casei, or Lactobacillus plantarum (SMD, -0.53; 95% CI, -1.00; -0.06) species. All probiotic species tested improved flatulence: B. breve (SMD, -0.42; 95% CI, -0.75;- 0.10), B. infantis, L. casei, L. plantarum (SMD, -0.60; 95% CI, -1.07; -0.13), B. longum, L. acidophilus, Lactobacillus bulgaricus, and Streptococcus salivarius ssp. thermophilus (SMD, -0.61; 95% CI, -1.01; -0.21). There was not a clear positive effect of probiotics concerning the quality of life. CONCLUSIONS: some probiotics are an effective therapeutic option for IBS patients, and the effects on each IBS symptom are likely species-specific. Future studies must focus on the role of probiotics in modulating intestinal microbiota and the immune system while considering individual patient symptom profiles. SN - 1130-0108 UR - https://www.unboundmedicine.com/medline/citation/23548007/Effect_of_probiotic_species_on_irritable_bowel_syndrome_symptoms:_A_bring_up_to_date_meta_analysis_ L2 - http://www.grupoaran.com/mrmUpdate/lecturaPDFfromXML.asp?IdArt=4620478&TO=RVN&Eng=1 DB - PRIME DP - Unbound Medicine ER -