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Single application of 4% dimeticone liquid gel versus two applications of 1% permethrin creme rinse for treatment of head louse infestation: a randomised controlled trial.
BMC Dermatol. 2013 Apr 01; 13:5.BD

Abstract

BACKGROUND

A previous study indicated that a single application of 4% dimeticone liquid gel was effective in treating head louse infestation. This study was designed to confirm this in comparison with two applications of 1% permethrin.

METHODS

We have performed a single centre parallel group, randomised, controlled, open label, community based trial, with domiciliary visits, in Cambridgeshire, UK. Treatments were allocated through sealed instructions derived from a computer generated list. We enrolled 90 children and adults with confirmed head louse infestation analysed by intention to treat (80 per-protocol after 4 drop outs and 6 non-compliant). The comparison was between 4% dimeticone liquid gel applied once for 15 minutes and 1% permethrin creme rinse applied for 10 minutes, repeated after 7 days as per manufacturer's directions. Evaluated by elimination of louse infestation after completion of treatment application regimen.

RESULTS

Intention to treat comparison of a single dimeticone liquid gel treatment with two of permethrin gave success for 30/43 (69.8%) of the dimeticone liquid gel group and 7/47 (14.9%) of the permethrin creme rinse group (OR 13.19, 95% CI 4.69 to 37.07) (p < 0.001). Per protocol results were similar with 27/35 (77.1%) success for dimeticone versus 7/45 (15.6%) for permethrin. Analyses by household gave essentially similar outcomes.

CONCLUSIONS

The study showed one 15 minute application of 4% dimeticone liquid gel was superior to two applications of 1% permethrin creme rinse (p < 0.001). The low efficacy of permethrin suggests it should be withdrawn.

TRIAL REGISTRATION

Current Controlled Trials ISRCTN88144046.

Authors+Show Affiliations

Medical Entomology Centre, Insect Research & Development Limited, 6 Quy Court, Colliers Lane, Stow-cum-Quy, Cambridge CB25 9AU, UK. ian@insectresearch.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23548062

Citation

Burgess, Ian F., et al. "Single Application of 4% Dimeticone Liquid Gel Versus Two Applications of 1% Permethrin Creme Rinse for Treatment of Head Louse Infestation: a Randomised Controlled Trial." BMC Dermatology, vol. 13, 2013, p. 5.
Burgess IF, Brunton ER, Burgess NA. Single application of 4% dimeticone liquid gel versus two applications of 1% permethrin creme rinse for treatment of head louse infestation: a randomised controlled trial. BMC Dermatol. 2013;13:5.
Burgess, I. F., Brunton, E. R., & Burgess, N. A. (2013). Single application of 4% dimeticone liquid gel versus two applications of 1% permethrin creme rinse for treatment of head louse infestation: a randomised controlled trial. BMC Dermatology, 13, 5. https://doi.org/10.1186/1471-5945-13-5
Burgess IF, Brunton ER, Burgess NA. Single Application of 4% Dimeticone Liquid Gel Versus Two Applications of 1% Permethrin Creme Rinse for Treatment of Head Louse Infestation: a Randomised Controlled Trial. BMC Dermatol. 2013 Apr 1;13:5. PubMed PMID: 23548062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single application of 4% dimeticone liquid gel versus two applications of 1% permethrin creme rinse for treatment of head louse infestation: a randomised controlled trial. AU - Burgess,Ian F, AU - Brunton,Elizabeth R, AU - Burgess,Nazma A, Y1 - 2013/04/01/ PY - 2013/01/03/received PY - 2013/03/27/accepted PY - 2013/4/4/entrez PY - 2013/4/4/pubmed PY - 2013/6/7/medline SP - 5 EP - 5 JF - BMC dermatology JO - BMC Dermatol VL - 13 N2 - BACKGROUND: A previous study indicated that a single application of 4% dimeticone liquid gel was effective in treating head louse infestation. This study was designed to confirm this in comparison with two applications of 1% permethrin. METHODS: We have performed a single centre parallel group, randomised, controlled, open label, community based trial, with domiciliary visits, in Cambridgeshire, UK. Treatments were allocated through sealed instructions derived from a computer generated list. We enrolled 90 children and adults with confirmed head louse infestation analysed by intention to treat (80 per-protocol after 4 drop outs and 6 non-compliant). The comparison was between 4% dimeticone liquid gel applied once for 15 minutes and 1% permethrin creme rinse applied for 10 minutes, repeated after 7 days as per manufacturer's directions. Evaluated by elimination of louse infestation after completion of treatment application regimen. RESULTS: Intention to treat comparison of a single dimeticone liquid gel treatment with two of permethrin gave success for 30/43 (69.8%) of the dimeticone liquid gel group and 7/47 (14.9%) of the permethrin creme rinse group (OR 13.19, 95% CI 4.69 to 37.07) (p < 0.001). Per protocol results were similar with 27/35 (77.1%) success for dimeticone versus 7/45 (15.6%) for permethrin. Analyses by household gave essentially similar outcomes. CONCLUSIONS: The study showed one 15 minute application of 4% dimeticone liquid gel was superior to two applications of 1% permethrin creme rinse (p < 0.001). The low efficacy of permethrin suggests it should be withdrawn. TRIAL REGISTRATION: Current Controlled Trials ISRCTN88144046. SN - 1471-5945 UR - https://www.unboundmedicine.com/medline/citation/23548062/Single_application_of_4_dimeticone_liquid_gel_versus_two_applications_of_1_permethrin_creme_rinse_for_treatment_of_head_louse_infestation:_a_randomised_controlled_trial_ L2 - https://bmcdermatol.biomedcentral.com/articles/10.1186/1471-5945-13-5 DB - PRIME DP - Unbound Medicine ER -