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Assessment of nanosilver toxicity during zebrafish (Danio rerio) development.
Chemosphere. 2013 Jun; 92(1):59-66.C

Abstract

Nanomaterials (NMs) including silver nanoparticles (AgNPs) are incorporated into an increasing number of consumer and medical products. However, the potential toxicity of AgNPs to aquatic organisms is largely unknown. This study characterizes the effects of AgNPs on zebrafish (Danio rerio) development. The effects of silver ions (Ag(+)) and AgNPs were examined at equivalent Ag concentrations, which ranged from 0.03 to 1.55 μg mL(-1) total Ag. The Ag(+) was more toxic than AgNPs but both lead to death and delayed hatching in surviving embryos. Both silver types depleted glutathione levels but generally did not affect antioxidant enzymes activities. In addition to silver some of the embryos were also exposed to cysteine, which generally reduced the toxicity of both silver types. This study demonstrates that AgNPs and Ag(+) are capable of inducing toxicity in zebrafish embryos including the induction of oxidative stress.

Authors+Show Affiliations

Department of Biology & Centre for Advanced Research in Environmental Genomics, University of Ottawa, Ottawa, Ontario, Canada. amass017@uottawa.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23548591

Citation

Massarsky, Andrey, et al. "Assessment of Nanosilver Toxicity During Zebrafish (Danio Rerio) Development." Chemosphere, vol. 92, no. 1, 2013, pp. 59-66.
Massarsky A, Dupuis L, Taylor J, et al. Assessment of nanosilver toxicity during zebrafish (Danio rerio) development. Chemosphere. 2013;92(1):59-66.
Massarsky, A., Dupuis, L., Taylor, J., Eisa-Beygi, S., Strek, L., Trudeau, V. L., & Moon, T. W. (2013). Assessment of nanosilver toxicity during zebrafish (Danio rerio) development. Chemosphere, 92(1), 59-66. https://doi.org/10.1016/j.chemosphere.2013.02.060
Massarsky A, et al. Assessment of Nanosilver Toxicity During Zebrafish (Danio Rerio) Development. Chemosphere. 2013;92(1):59-66. PubMed PMID: 23548591.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of nanosilver toxicity during zebrafish (Danio rerio) development. AU - Massarsky,Andrey, AU - Dupuis,Lisa, AU - Taylor,Jessica, AU - Eisa-Beygi,Shahram, AU - Strek,Laura, AU - Trudeau,Vance L, AU - Moon,Thomas W, Y1 - 2013/03/30/ PY - 2012/09/30/received PY - 2013/02/11/revised PY - 2013/02/20/accepted PY - 2013/4/4/entrez PY - 2013/4/4/pubmed PY - 2013/11/8/medline SP - 59 EP - 66 JF - Chemosphere JO - Chemosphere VL - 92 IS - 1 N2 - Nanomaterials (NMs) including silver nanoparticles (AgNPs) are incorporated into an increasing number of consumer and medical products. However, the potential toxicity of AgNPs to aquatic organisms is largely unknown. This study characterizes the effects of AgNPs on zebrafish (Danio rerio) development. The effects of silver ions (Ag(+)) and AgNPs were examined at equivalent Ag concentrations, which ranged from 0.03 to 1.55 μg mL(-1) total Ag. The Ag(+) was more toxic than AgNPs but both lead to death and delayed hatching in surviving embryos. Both silver types depleted glutathione levels but generally did not affect antioxidant enzymes activities. In addition to silver some of the embryos were also exposed to cysteine, which generally reduced the toxicity of both silver types. This study demonstrates that AgNPs and Ag(+) are capable of inducing toxicity in zebrafish embryos including the induction of oxidative stress. SN - 1879-1298 UR - https://www.unboundmedicine.com/medline/citation/23548591/Assessment_of_nanosilver_toxicity_during_zebrafish__Danio_rerio__development_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0045-6535(13)00368-8 DB - PRIME DP - Unbound Medicine ER -