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Osthole ameliorates renal ischemia-reperfusion injury by inhibiting inflammatory response.
Urol Int. 2013; 91(3):350-6.UI

Abstract

INTRODUCTION

Renal ischemia-reperfusion (I/R) injury is a primary cause of acute renal failure that results in high mortality. This study aimed to investigate the effect of osthole, a natural coumarin derivative, on renal I/R injury in a rat model.

MATERIALS AND METHODS

Rats were randomly allocated to the sham operation + vehicle, I/R + vehicle, and I/R + osthole groups. Renal I/R injury was induced by clamping the left renal artery for 45 min followed by 12 h of reperfusion and a contralateral nephrectomy. Osthole (40 mg/kg) was intraperitoneally injected 30 min before inducing I/R. Renal function and histological damage were determined subsequently. Myeloperoxidase activity, monocyte/macrophage infiltration, as well as tumor necrosis factor-α, IL-1β, and activated p38 mitogen-activated protein kinase expression in kidneys were also assessed.

RESULTS

Osthole treatment significantly ameliorated I/R-induced renal functional and morphological injuries. Moreover, osthole treatment attenuated myeloperoxidase activity, monocyte/macrophage infiltration, and tumor necrosis factor-α, IL-1β, and activated p38 mitogen-activated protein kinase expression in kidneys.

CONCLUSIONS

Osthole treatment ameliorates renal I/R injury by inhibiting inflammatory responses in kidneys. Thus, osthole may represent a novel practical strategy to prevent renal I/R injury.

Authors+Show Affiliations

Department of Urology, Peking University Third Hospital, Beijing, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23548945

Citation

Zheng, Yi, et al. "Osthole Ameliorates Renal Ischemia-reperfusion Injury By Inhibiting Inflammatory Response." Urologia Internationalis, vol. 91, no. 3, 2013, pp. 350-6.
Zheng Y, Lu M, Ma L, et al. Osthole ameliorates renal ischemia-reperfusion injury by inhibiting inflammatory response. Urol Int. 2013;91(3):350-6.
Zheng, Y., Lu, M., Ma, L., Zhang, S., Qiu, M., & Ma, X. (2013). Osthole ameliorates renal ischemia-reperfusion injury by inhibiting inflammatory response. Urologia Internationalis, 91(3), 350-6. https://doi.org/10.1159/000347191
Zheng Y, et al. Osthole Ameliorates Renal Ischemia-reperfusion Injury By Inhibiting Inflammatory Response. Urol Int. 2013;91(3):350-6. PubMed PMID: 23548945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osthole ameliorates renal ischemia-reperfusion injury by inhibiting inflammatory response. AU - Zheng,Yi, AU - Lu,Min, AU - Ma,Lulin, AU - Zhang,Shudong, AU - Qiu,Min, AU - Ma,Xin, Y1 - 2013/03/23/ PY - 2012/11/09/received PY - 2013/01/14/accepted PY - 2013/4/4/entrez PY - 2013/4/4/pubmed PY - 2014/6/16/medline SP - 350 EP - 6 JF - Urologia internationalis JO - Urol Int VL - 91 IS - 3 N2 - INTRODUCTION: Renal ischemia-reperfusion (I/R) injury is a primary cause of acute renal failure that results in high mortality. This study aimed to investigate the effect of osthole, a natural coumarin derivative, on renal I/R injury in a rat model. MATERIALS AND METHODS: Rats were randomly allocated to the sham operation + vehicle, I/R + vehicle, and I/R + osthole groups. Renal I/R injury was induced by clamping the left renal artery for 45 min followed by 12 h of reperfusion and a contralateral nephrectomy. Osthole (40 mg/kg) was intraperitoneally injected 30 min before inducing I/R. Renal function and histological damage were determined subsequently. Myeloperoxidase activity, monocyte/macrophage infiltration, as well as tumor necrosis factor-α, IL-1β, and activated p38 mitogen-activated protein kinase expression in kidneys were also assessed. RESULTS: Osthole treatment significantly ameliorated I/R-induced renal functional and morphological injuries. Moreover, osthole treatment attenuated myeloperoxidase activity, monocyte/macrophage infiltration, and tumor necrosis factor-α, IL-1β, and activated p38 mitogen-activated protein kinase expression in kidneys. CONCLUSIONS: Osthole treatment ameliorates renal I/R injury by inhibiting inflammatory responses in kidneys. Thus, osthole may represent a novel practical strategy to prevent renal I/R injury. SN - 1423-0399 UR - https://www.unboundmedicine.com/medline/citation/23548945/Osthole_ameliorates_renal_ischemia_reperfusion_injury_by_inhibiting_inflammatory_response_ L2 - https://www.karger.com?DOI=10.1159/000347191 DB - PRIME DP - Unbound Medicine ER -