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Alcohol, liver, systemic inflammation and skin: a focus on patients with psoriasis.
Skin Pharmacol Physiol 2013; 26(3):119-26SP

Abstract

Emerging evidence suggests that excessive alcohol consumption is associated with psoriasis. In alcoholics, antipsoriatic treatments are less efficient, but more toxic and an additional challenge is poor therapeutic compliance. There is a correlation between excess alcohol intake and increased risk of infections, but on the other hand alcohol and its metabolites can trigger a persistent systemic inflammation, mediated by pro-inflammatory cytokines released from activated Kupffer cells in the liver and from monocytes in the circulation. Ethanol and its metabolites can also enhance lymphocyte and keratinocyte activation and proliferation and can increase the mRNA levels of genes characteristic for proliferating keratinocytes. In this review, we discuss the mechanisms by which alcohol contributes to psoriasis development focusing on liver, systemic inflammation and skin.

Authors+Show Affiliations

Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary. farkas.arpad@med.u-szeged.huNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23549156

Citation

Farkas, A, and L Kemény. "Alcohol, Liver, Systemic Inflammation and Skin: a Focus On Patients With Psoriasis." Skin Pharmacology and Physiology, vol. 26, no. 3, 2013, pp. 119-26.
Farkas A, Kemény L. Alcohol, liver, systemic inflammation and skin: a focus on patients with psoriasis. Skin Pharmacol Physiol. 2013;26(3):119-26.
Farkas, A., & Kemény, L. (2013). Alcohol, liver, systemic inflammation and skin: a focus on patients with psoriasis. Skin Pharmacology and Physiology, 26(3), pp. 119-26. doi:10.1159/000348865.
Farkas A, Kemény L. Alcohol, Liver, Systemic Inflammation and Skin: a Focus On Patients With Psoriasis. Skin Pharmacol Physiol. 2013;26(3):119-26. PubMed PMID: 23549156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol, liver, systemic inflammation and skin: a focus on patients with psoriasis. AU - Farkas,A, AU - Kemény,L, Y1 - 2013/03/21/ PY - 2012/12/10/received PY - 2013/02/11/accepted PY - 2013/4/4/entrez PY - 2013/4/4/pubmed PY - 2014/1/17/medline SP - 119 EP - 26 JF - Skin pharmacology and physiology JO - Skin Pharmacol Physiol VL - 26 IS - 3 N2 - Emerging evidence suggests that excessive alcohol consumption is associated with psoriasis. In alcoholics, antipsoriatic treatments are less efficient, but more toxic and an additional challenge is poor therapeutic compliance. There is a correlation between excess alcohol intake and increased risk of infections, but on the other hand alcohol and its metabolites can trigger a persistent systemic inflammation, mediated by pro-inflammatory cytokines released from activated Kupffer cells in the liver and from monocytes in the circulation. Ethanol and its metabolites can also enhance lymphocyte and keratinocyte activation and proliferation and can increase the mRNA levels of genes characteristic for proliferating keratinocytes. In this review, we discuss the mechanisms by which alcohol contributes to psoriasis development focusing on liver, systemic inflammation and skin. SN - 1660-5535 UR - https://www.unboundmedicine.com/medline/citation/23549156/Alcohol_liver_systemic_inflammation_and_skin:_a_focus_on_patients_with_psoriasis_ L2 - https://www.karger.com?DOI=10.1159/000348865 DB - PRIME DP - Unbound Medicine ER -