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Dietary fat, fatty acids, and risk of prostate cancer in the NIH-AARP diet and health study.
Cancer Epidemiol Biomarkers Prev 2013; 22(4):697-707CE

Abstract

BACKGROUND

Observational studies report inconsistent associations of fat and fatty acids with prostate cancer.

METHODS

We investigated associations between dietary fats and fatty acids and risk of prostate cancer in the NIH-American Association of Retired Persons (AARP) Diet and Health Study. Diet was assessed at baseline with self-administered food-frequency questionnaires. Cases were determined by linkage with state cancer registries. HR and 95% confidence intervals (CI) were estimated with Cox proportional hazards models.

RESULTS

Among 288,268 men with average follow-up of nine years, 23,281 prostate cancer cases (18,934 nonadvanced and 2,930 advanced including 725 fatal cases) were identified. Total fat and mono- and polyunsaturated fat intakes were not associated with incidence of prostate cancer. Saturated fat intake was related to increased risk of advanced prostate cancer (HRQuintile 5 vs. Qunitile 1 (Q1 vs. Q5), 1.21; 95% CI, 1.00-1.46; Ptrend = 0.03) and fatal prostate cancer (HRQ5 vs. Q1, 1.47; 95% CI, 1.01-2.15; Ptrend = 0.04). α-Linolenic acid (ALA) intake was related to increased risk of advanced prostate cancer (HRQ5 vs. Q1, 1.17; 95% CI, 1.04-1.31; Ptrend = 0.01). Eicosapentanoic acid (EPA) intake was related to decreased risk of fatal prostate cancer (HRQ5 vs. Q1, 0.82; 95% CI, 0.64-1.04; Ptrend = 0.02).

CONCLUSION

Our study suggests that the associations of fat and fatty acids differ by prostate cancer severity. Saturated fat, ALA, and EPA intakes were related to the risk of advanced or fatal prostate cancer but not to nonadvanced prostate cancer.

IMPACT

Identifying factors associated with advanced prostate cancer could reduce morbidity and mortality.

Authors+Show Affiliations

Cancer Prevention Fellowship Program, National Cancer Institute, 6120 Executive Blvd., EPS 3025, Bethesda, MD 20852, USA. colleen.pelser@nih.govNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

23549401

Citation

Pelser, Colleen, et al. "Dietary Fat, Fatty Acids, and Risk of Prostate Cancer in the NIH-AARP Diet and Health Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 22, no. 4, 2013, pp. 697-707.
Pelser C, Mondul AM, Hollenbeck AR, et al. Dietary fat, fatty acids, and risk of prostate cancer in the NIH-AARP diet and health study. Cancer Epidemiol Biomarkers Prev. 2013;22(4):697-707.
Pelser, C., Mondul, A. M., Hollenbeck, A. R., & Park, Y. (2013). Dietary fat, fatty acids, and risk of prostate cancer in the NIH-AARP diet and health study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 22(4), pp. 697-707. doi:10.1158/1055-9965.EPI-12-1196-T.
Pelser C, et al. Dietary Fat, Fatty Acids, and Risk of Prostate Cancer in the NIH-AARP Diet and Health Study. Cancer Epidemiol Biomarkers Prev. 2013;22(4):697-707. PubMed PMID: 23549401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat, fatty acids, and risk of prostate cancer in the NIH-AARP diet and health study. AU - Pelser,Colleen, AU - Mondul,Alison M, AU - Hollenbeck,Albert R, AU - Park,Yikyung, PY - 2013/4/4/entrez PY - 2013/4/4/pubmed PY - 2013/11/1/medline SP - 697 EP - 707 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 22 IS - 4 N2 - BACKGROUND: Observational studies report inconsistent associations of fat and fatty acids with prostate cancer. METHODS: We investigated associations between dietary fats and fatty acids and risk of prostate cancer in the NIH-American Association of Retired Persons (AARP) Diet and Health Study. Diet was assessed at baseline with self-administered food-frequency questionnaires. Cases were determined by linkage with state cancer registries. HR and 95% confidence intervals (CI) were estimated with Cox proportional hazards models. RESULTS: Among 288,268 men with average follow-up of nine years, 23,281 prostate cancer cases (18,934 nonadvanced and 2,930 advanced including 725 fatal cases) were identified. Total fat and mono- and polyunsaturated fat intakes were not associated with incidence of prostate cancer. Saturated fat intake was related to increased risk of advanced prostate cancer (HRQuintile 5 vs. Qunitile 1 (Q1 vs. Q5), 1.21; 95% CI, 1.00-1.46; Ptrend = 0.03) and fatal prostate cancer (HRQ5 vs. Q1, 1.47; 95% CI, 1.01-2.15; Ptrend = 0.04). α-Linolenic acid (ALA) intake was related to increased risk of advanced prostate cancer (HRQ5 vs. Q1, 1.17; 95% CI, 1.04-1.31; Ptrend = 0.01). Eicosapentanoic acid (EPA) intake was related to decreased risk of fatal prostate cancer (HRQ5 vs. Q1, 0.82; 95% CI, 0.64-1.04; Ptrend = 0.02). CONCLUSION: Our study suggests that the associations of fat and fatty acids differ by prostate cancer severity. Saturated fat, ALA, and EPA intakes were related to the risk of advanced or fatal prostate cancer but not to nonadvanced prostate cancer. IMPACT: Identifying factors associated with advanced prostate cancer could reduce morbidity and mortality. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/23549401/Dietary_fat_fatty_acids_and_risk_of_prostate_cancer_in_the_NIH_AARP_diet_and_health_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=23549401 DB - PRIME DP - Unbound Medicine ER -